Tumour prothymosin alpha content, a potential prognostic marker for primary breast cancer

British Journal of Cancer

Volumn 82, Issue 3, 2000, Pages 584-590

  Magdalena, C ^b   Dominguez, F ^a   Loidi, L ^a   Puente, J L ^b  

^a Instituto de Nulridon Y Tecnologia Tie Alimentas   (Spain)

^b NONE

Author keywords

Overall mortality; Thymosin alpha 1 radioimmunoassay; Tumour proliferation marker

Indexed keywords

NUCLEAR PROTEIN; THYMOSIN;

ADULT; ARTICLE; AXILLARY LYMPH NODE; BREAST CANCER; CANCER GRADING; CANCER MORTALITY; CANCER RECURRENCE; CANCER SURVIVAL; CELL PROLIFERATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRADUCTAL CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; SPAIN;

EID: 0345803539     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.1999.0968     Document Type: Article

References (35)

1. Celis JE, Madsen P and Ryazanov AG (1990) Increased phosphorylation of elongation factor 2 during mitosis in transformed human amnion cells correlates with a decreased rate of protein synthesis. Proc Natl Acad Sci USA 87: 4231-4235
2. Conteas CN, Mutchnick MG, Palmer KC, Weller FE, Luk GD, Naylor PH, Erdos MR, Goldstein AL, Panneerselvam C and Horecker BL (1990) Cellular levels of thymosin immunoreactive peptides are linked to proliferative events: evidence for a nuclear site of action. Proc Natl Acad Sci USA 87: 3269-3273
3. Diaz JC, Perez EA, Covelo G and Freire M (1996) Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay. Biochim Biophys Acta 1296: 219-227
4. Dominguez F, Gallego R, Roson E, Loidi L and Garcia-Caballero T (1997) Prothymosin alpha distribution in normal and tumoral tissues. Int J Thymology 5: 474-476
5. Dominguez F, Magdalena C, Cancio E, Roson E, Paredes J, Loidi L, Zalvide J, Fraga M, Forteza J, Regueiro BJ and et al (1993) Tissue concentrations of prothymosin alpha: a novel proliferation index of primary breast cancer. Eur J Cancer 29A: 893-897
6. Eilers M, Schirm S and Bishop JM (1991) The MYC protein activates transcription of the alpha prothymosin gene. EMBO J 10: 133-141
7. Eschenfeldt WH and Berger SL (1986) The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA. Proc Natl Acad Sci USA 83: 9403-9407
8. Fraga M, Garcia CT, Dominguez F, Perez BE, Beiras A and Forteza J (1993) Immunohistochemical location of prothymosin alpha in regenerating human hepatocytes and hepatocellular carcinomas. Virchows Arch A Pathol Anat Histopathol 423: 449-452
9. Freedman LS, Edwards DN, McConnell EM and Downhay DY (1979) Histological grade and other prognosis factors in relation to survival of patients with breast cancer. Br J Cancer 40: 44-55
10. Gallego R, Roson E, Garcia CT, Fraga M, Forteza J, Dominguez F and Beiras A (1992) Prothymosin alpha expression in lymph nodes and tonsils: an optical and ultrastructural study. Acta Anat Basel 143: 219-222
11. Garcia CT, Dominguez F, Roson E, Gallego R, Zalvide J, Forteza J and Beiras A (1994) Distribution of prothymosin alpha in rat and human adrenal cortex. Anat Res 239: 88-94
12. Gomez-Marquez J and Rodriguez P (1998) Prothymosin alpha is a chromatin-remodelling protein in mammalian cells. Biochem J 333: 1-3
13. Gomez MJ and Segade F (1988) Prothymosin alpha is a nuclear protein. FEBS Lett 226: 217-219
14. Gomez MJ, Segade F, Dosil M, Pichel JG, Bustelo XR and Freire M (1989) The expression of prothymosin alpha gene in T lymphocytes and leukemic lymphoid cells is tied to lymphocyte proliferation. J Biol Chem 264: 8451-8454
15. Goodall GJ, Dominguez F and Horecker BL (1986) Molecular cloning of cDNA for human prothymosin alpha. Proc Natl Acad Sci USA 83: 8926-8928
16. Haritos AA, Goodall GJ and Horecker BL (1984). Prothymosin alpha: isolation and properties of the major immunoreactive form of thymosin alpha 1 in rat thymus. Proc Natl Acad Sci USA 81: 1008-1011
17. Loidi L, Garcia-Caballero T, Vidal A, Zalvide J, Gallego R and Dominguez F (1999) Complex regulation of prothymosin alpha in mammary tumors arising in transgenic mice. Life Sci 64: 2125-2133
18. Lu KP and Means AR (1993) Regulation of the cell cycle by calcium and calmodulin. Endocr Rev 14: 40-58
19. Mol PC, Wang RH, Batey DW, Lee LA, Dang CV and Berger SL (1995) Do products of the myc proto-oncogene play a role in transcriptional regulation of the prothymosin alpha gene? Mol Cell Biol 15: 6999-7009
20. Papamarcaki T and Tsolas O (1994) Prothymosin alpha binds to histone H1 in vitro. FEBS Lett 345: 71-75
21. Powles TJ (1997) Adjuvant therapy for early breast cancer: a time to refine. J Natl Cancer Inst 89: 1652-1654
22. Rodriguez P, Viñuela JE, Alvarez-Fernandez L, Buceta M, Vidal A, Dominguez F, Gomez-Marquez J (1998) Overexpression of prothymosin alpha accelerates proliferation and retards differentiation in HL-60 cells. Biochem J 331: 753-761
23. Rodriguez P, Vinuela JE, Alvarez-Fernandez L and Gomez-Marquez J (1999) Prothymosin alpha antisense oligonucleotides induce apoptosis in HL-60 cells. Cell Death Differ 6: 3-5
24. Roson E, Gallego R, Garcia CT, Heimer EP, Felix AM and Dominguez F (1990a) Prothymosin alpha expression is associated to cell division in rat testis. Histochemistry 94: 597-599
25. Roson E, Garcia CG, Heimer EP, Felix AM and Dominguez F (1990b) Cellular distribution of prothymosin alpha and parathymosin in rat thymus and spleen. J Histochem Cytochem 38: 1889-1894
26. Roson E, Gallego R, Garcia CT, Fraga M, Dominguez F and Beiras A (1993) Evolution of prothymosin alpha and proliferating cell nuclear antigen (PCNA) immunoreactivity through the development of rat ovarian follicles. Histochem J 25: 497-501
27. Rudolph P, Alm P, Heidebrecht H-J, Bolte H, Ratjen V, Baldetorp B et al (1999) Immunologic proliferation marker Ki-S2 as prognostic indicator for lymph node-negative breast cancer. J Natl Cancer Inst 91: 271-278
28. 2+/calmodulin-dependent phosphorylation of elongation factor 2. FEBS Lett 214: 331-334
29. Sburlati AR, Manrow RE and Berger SL (1991) Prothymosin alpha antisense oligomers inhibit mycloma cell division. Proc Natl Acad Sci USA 88: 253-257
30. Sigurdsson H, Baldetorp B, Borg A, Dlberg M, Fernö M, Killander D and Olsson H (1990) Indicators of prognosis in node-negative breast cancer. N Engl J Med 322: 1045-1053
31. Tsitsilonis OE, Bekris E, Voutsas IF, Baxevanis CN, Markopoulos C, Papadopoulou SA, Kontzoglou K, Stoeva S, Gogas J, Voelter W and Papamichail M (1998) The prognostic value of alpha-thymosins in breast cancer. Anticancer Res 18: 1501-1508
32. Vareli K, Tsolas O and Frangou LM (1996) Regulation of prothymosin alpha during the cell cycle. Eur J Biochem 238: 799-806
33. 2+ dependent phosphorylation of elongation factor 2 in cellular extracts. J Biol Chem 273: 10147-10152
34. Witzig TE, Ingle JN, Cha SS, Schaid DJ, Tabery RL, Wold LE et al (1994) DNA ploidy and the percentage of cells in S-phase as prognostic factors for women with lymph node negative breast cancer. Cancer 74: 1752-1761
35. Zalvide JB, Cancio E, Alvarez CV, Regueiro BJ and Dominguez F (1992) Prothymosin alpha mRNA levels are invariant throughout the cell cycle. J Biol Chem 267: 8692-8695