Peroxynitrite Inhibits Epidermal Growth Factor Receptor Signaling in Caco-2 Cells

Digestive Diseases and Sciences

Volumn 48, Issue 12, 2003, Pages 2353-2359

  Uc, Aliye ^a   Kooy, Neil W ^b   Conklin, Jeffrey L ^c   Bishop, Warren P ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Cell signaling; Epidermal growth factor; Intestinal epithelial cells; Nitric oxide; Oxidative stress; Peroxynitrite

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; NITRIC OXIDE; PEROXYNITRITE; TYROSINE;

ARTICLE; AUTOPHOSPHORYLATION; CELL MEMBRANE; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN A431; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INFLAMMATION; INTESTINE; INTESTINE EPITHELIUM; INTESTINE MUCOSA; NITRATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

CACO-2 CELLS; CELL DIVISION; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNOBLOTTING; IODINE RADIOISOTOPES; PEROXYNITROUS ACID; PRECIPITIN TESTS; RECEPTOR, EPIDERMAL GROWTH FACTOR; THYMIDINE; TRITIUM;

EID: 0345802745     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:DDAS.0000007874.20403.1d     Document Type: Article

References (41)

1. Kagnoff MF, Eckmann L: Epithelial cells as sensors for microbial infection: J Clin Invest 100:6-10, 1997
2. Podolsky DK: Going the distance - The case for true colorectal-cancer screening. N Engl J Med 343:207-208, 2000
3. DeMeo MT, Mutlu EA, Keshavarzian A, Tobin MC: Intestinal permeation and gastrointestinal disease. J Clin Gastroenterol 34:385-396, 2002
4. Zijlstra RT, Odle J, Hall WF, Petschow BW, Gelberg HB, Litov RE: Effect of orally administered epidermal growth factor on intestinal recovery of neonatal pigs infected with rotavirus. J Pediatr Gastroenterol Nutr 19:382-390, 1994
5. Ardawi MS: Effects of epidermal growth factor and glutamine-supplemented parenteral nutrition on the small bowel of septic rats. Clin Sci 82:573-580, 1992
6. Dignass AU: Mechanisms and modulation of intestinal epithelial repair. Inflam Bowel Dis 7:68-77, 2001
7. Jones MK, Tomikawa M, Mohajer B, Tarnawski AS: Gastrointestinal mucosal regeneration: role of growth factors. Frontiers Biosci 4:D303-D309, 1999
8. Dignass AU, Podolsky DK: Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Gastroenterology 105:1323-1332, 1993
9. Riegler M, Sedivy R, Sogukoglu T, Cosentini E, Bischof G, Teleky B, Feil W, Schiessel R, Hamilton G, Wenzl E: Epidermal growth factor promotes rapid response to epithelial injury in rabbit duodenum in vitro. Gastroenterology 111:28-36, 1996
10. Goodlad RA, Wright NA: Epidermal growth factor and transforming growth factor-alpha actions on the gut. Eur J Gastroenterol Hepatol 7:928-932, 1995
11. Walker-Smith JA, Phillips AD, Walford N, Gregory H, Fitzgerald JD, MacCullagh K, Wright NA: Intravenous epidermal growth factor/urogastrone increases small-intestinal cell proliferation in congenital microvillous atrophy. Lancet 2:1239-1240, 1985
12. Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212, 1990
13. Danker K, Mechai N, Lucka L, Reutter W, Horstkorte R: The small Gtpase ras in involved in growth factor-regulated expression of the alpha1 integrin subunit in PC12 cells. Biol Chem 382:969-972, 2001
14. Zhao D, Letterman J, Schreiber BM: Beta-migrating very low density lipoprotein (beta VLDL) activates smooth muscle cell mitogen-activated protein (MAP) kinase via G protein-coupled receptor-mediated transactivation of the epidermal growth factor (EGF) receptor: effect of MAP kinase activation on beta VLDL plusEGF-induced cell proliferation. J Biol Chem 276:30579-30588, 2001
15. Decker SJ: Transmembrane signaling by epidermal growth factor receptors lacking autophosphorylation sites. J Biol Chem 268:9176-9179, 1993
16. Kubes P, McCafferty DM: Nitric oxide and intestinal inflammation. Am J Med 109:150-158, 2000
17. Eckmann L, Stenson WF, Savidge TC, Lowe DC, Barrett KE, Fierer J, Smith JR, Kagnoff MF: Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production. J Clin Invest 100:296-309, 1997
18. Dignass AU, Podolsky DK, Rachmilewitz D: NO chi generation by cultured small intestinal epithelial cells. Dig Dis Sci 40:1859-1865, 1995
19. Miller MJ, Thompson JH, Zhang XJ, Sadowska-Krowicka H, Kakkis JL, Munshi UK, Sandoval M, Rossi JL, Eloby-Childress S, Beckman JS: Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology 109:1475-1483, 1995
20. Singer II, Kawka DW, Scott S, Weidner JR, Mumford RA, Riehl TE, Stenson WF: Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology 111:871-885, 1996
21. Beckman JS, Crow JP: Pathological implications of nitric oxide, superoxide and peroxynitrite formation. Biochem Soc Trans 21:330-334, 1993
22. Ischiropoulos H, al Mehdi AB: Peroxynitrite-mediated oxidative protein modifications. FEBS Lett 364:279-282, 1995
23. Pryor WA, Squadrito GL: The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol 268:L699-L722, 1995
24. Gow AJ, Duran D, Malcolm S, Ischiropoulos H: Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation. FEBS Lett 385:63-66, 1996
25. Kong SK, Yim MB, Stadtman ER, Chock PB: Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide. Proc Natl Acad Sci USA 93:3377-3382, 1996
26. Bishop WP, Wen JT: Regulation of Caco-2 cell proliferation by basolateral membrane epidermal growth factor receptors. Am J Physiol 267:G892-G900, 1994
27. Grasset E, Pinto M, Dussaulx E, Zweibaum A, Desjeux JF: Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters. Am J Physiol 247:C260-C267, 1984
28. Zweibaum A, Triadou N, Kedinger M, Augeron C, Robine-Leon S, Pinto M, Rousset M, Haffen K: Sucrase-isomaltase: a marker of foetal and malignant epithelial cells of the human colon. Int J Cancer 32:407-412, 1983
29. Hansen MB, Nielsen SE, Berg K: Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119:203-210, 1989
30. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624, 1990
31. Woltjer RL, Staros JV: Effects of sulfhydryl modification reagents on the kinase activity of the epidermal growth factor receptor. Biochemistry 36:9911-9916, 1997
32. Clark S, Konstantopoulos N: Sulphydryl agents modulate insulin-and epidermal growth factor (EGF)-receptor kinase via reaction with intracellular receptor domains: differential effects on basal versus activated receptors. Biochem 292:217-223, 1993
33. van d, V, Hristova M, Cross CE, Eiserich JP, Goldkorn T: Peroxynitrite induces covalent dimerization of epidermal growth factor receptors in A431 epidermoid carcinoma cells. J Biol Chem 273:31860-31866, 1998
34. Salman-Tabcheh S, Guerin MC, Torreilles J: Nitration of tyrosyl-residues from extra-and intracellular proteins in human whole blood. Free Rad Biol Med 19:695-698, 1995
35. Estrada C, Gomez, C, Martin-Nieto J, De Frutos T, Jimenez A, Villalobo A: Nitric oxide reversibly inhibits the epidermal growth factor receptor tyrosine kinase. Biochem J 326:369-376, 1997
36. Ischiropoulos H, Zhu L, Beckman JS: Peroxynitrite formation from macrophage-derived nitric oxide. Arch Biochem Biophys 298:446-451, 1992
37. Fukuyama N, Ichimori K, Su Z, Ishida H, Nakazawa H: Peroxynitrite formation from activated human leukocytes. Biochem Biophys Res Commun 224:414-419, 1996
38. Zhu L, Gunn C, Beckman JS: Bactericidal activity of peroxynitrite. Arch Biochem Biophys 298:452-457, 1992
39. Miller MJ, Zhang XJ, Sadowska-Krowicka H, Chotinaruemol S, McIntyre JA, Clark DA, Bustamante SA: Nitric oxide release in response to gut injury. Scand J of Gastroenterol 28:149-154, 1993
40. Radi R, Peluffo G, Alvarez MN, Naviliat M, Cayota A: Unraveling peroxynitrite formation in biological systems. Free Rad Biol Med 30:463-488, 2001
41. Eiserich JP, Hristova M, Cross CE, Jones AD, Freeman BA, Halliwell B, van d, V: Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutophils. Nature 391:393-397, 1998