The investigation of the genotoxic effects of fenarimol and propamocarb in mouse bone marrow in vivo

Toxicology Letters

Volumn 147, Issue 1, 2004, Pages 73-78

  Aydemir, Nilüfer ^a   Bilaloǧlu, Rahmi ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

Bone marrow; Chromosome aberrations; Fenarimol; Fungicides; Micronucleus; Mouse; Propamocarb

Indexed keywords

FENARIMOL; FUNGICIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; ERYTHROCYTE; GENOTOXICITY; MICRONUCLEUS; MITOSIS INDEX; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROPAMOCARB;

FUNGI;

EID: 0345791461     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2003.10.015     Document Type: Article

References (16)

1. Adler, I.D., 1984. Cytogenetic tests in mammals. In: Venitt S., Parry, J. (Eds.), Mutagenicity Testing: A Practical Approach, IRL Press, Oxford, pp. 273-306.
2. Albert, R., Baker, S., Doull, S., Butler, G., Nelson, N., Peakall, D., Pimentel, D., Tardiff, R.G., 1992. Introduction, general conclusion and recommendations. In: Tardiff, R.G. (Ed.), Methods to assess adverse effects of pesticides on non-target organisms. Wiley, New York, pp. 3-13.
3. Bellicampi D., Gualandi G., La Monica E., Poley C., Morpurgo G.D. Membrane-damaging agents cause mitotic non-disjunction in Aspergillus nidulans. Mutat. Res. 79:1980;169-172.
4. Cantelli-Forti G., Paolini M., Hrelia P. Multiple end point procedure to evaluate risk from pesticides. J. Env. Health Perspect. 101(Suppl. 3):1993;15-20.
5. Environmental Protection Agency. EPA, 1985. Pesticide fact sheet "fenarimol". Toxicol. Chem. 207(1), 1-9.
6. Fernandez-Alba A.R., Guil L.H., Lopez G.D., Chisti Y. Toxicity of pesticides in wastewater: a comparative assessment of rapid bioassays. Anal. Chim. Acta. 426:2001;289-301.
7. Flodstrom S., Hemming H., Warngard L., Ahlborg V.G. Promotion of altered hepatic foci development in rat liver cytochrome P450 enzyme induction and inhibition of cell-cell communication by DDT and some structurally related organohalogen pesticides. Carcinogenesis. 11:1990;1413-1418.
8. Grilli S., Ancora G., Rani P., Valenti A.P., Mazzullo M., Colacci A.M. In vivo unwinding fluorometric assay as evidence of the damage induced by fenarimol and DNOC in rat liver DNA. J. Toxicol. Environ. Health. 34:1991;485-494.
9. IPCS, 1985. Guide to short-term tests for detecting mutagenic and carcinogenic chemicals, vol. 208. Environmental Health Criteria, World Health Organization, Geneva, 51, pp. 102-103.
10. Kostka G., Palut D., Kopec-Szlezak J., Ludwicki J.K. Early hepatic changes in rats induced by permethrin in comparison with DDT. Toxicology. 142:2000;135-143.
11. Paolini M., Mesirca R., Pozzetti L., Maffei F., Vigagni F., Hrelia P., Cantelli-Forti G. Genetic and non-genetic biomarkers related to carcinogenesis in evaluating toxicological risk from fenarimol. Mutat. Res. 368:1996a;27-39.
12. Paolini M., Mesirca R., Pozzetti L., Sapone A., Cantelli-Forti G. Molecular non-genetic biomarkers related to fenarimol cocarcinogenesis: organ and sex specific CYP induction in rat. Cancer Lett. 101:1996b;171-178.
13. Preston R.J., Dean B.J., Galloway S., Holden H., McFee A.F., Shelby M. Mammalian in vivo cytogenetic assays: analysis of chromosome aberrations in bone-marrow cells. Mutat. Res. 189:1987;157-165.
14. Tyrkiel E., Ludwicki J.K. The influence of DDT analogues (nuarimol and fenarimol) on the frequency of occurence of micronuclei in erythrocytes of bone marrow and spleen in mice. Rocz. Panstw. Zakl. Hig. 43(3-4):1992;325-331.
15. Tyrkiel E., Wiadrowska B., Ludwicki J.K. Induction of micronuclei in erythrocytes of bone marrow and peripheral blood in laboratory mice following acute and subchronic exposure to DDT (fenarimol and nuarimol). Rocz. Panstw. Zakl. Hig. 47(2):1996;151-158.
16. Vasudev V., Krishnamurthy N.B. In vivo cytogenetic analyses of the carbamate pesticides Dithane M-45 and Baygon in mice. Mutat. Res. 323:1994;133-135.