Indirect evidence of hormone abuse. Proof of doping?

Journal of Endocrinological Investigation

Volumn 26, Issue 9, 2003, Pages 919-923

  Minuto, F ^a   Barreca, A ^a   Melioli, G ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

Author keywords

Erythropoietin abuse; GH abuse; IGF I; IGFBP; PIIIP

Indexed keywords

ACETYLSALICYLIC ACID; ACTOVEGIN; ACTRAPID NOVOLET; ALPHA TOCOPHEROL; ALPHALIPON; ANABOLIC AGENT; ANTIBODY; BENEXOL; BETAMETHASONE; BETAMETHASONE SODIUM PHOSPHATE; CAFIASPIRINA; CARBOXY TERMINAL TELOPEPTIDE; DICLOFENAC; DIPROPHYLLINE; DROTAVERINE; DURVITAN; ERYTHROPOIETIN; GONADOTROPIN; GROWTH HORMONE; HETASTARCH; HORMONE; HUMAN GROWTH HORMONE; ICIP PEPTIDE; IMMUNOFERON; INSULIN; KETOCONAZOLE; KETONAL; LEVOTHYROXINE SODIUM; OLTRAMP; OPTALIDON; OSTEOCALCIN; OZOTHINE; PENTOHEXAL; PEPTIDE; PIUP PEPTIDE; POLYSACCHARIDE; PRAXILEN; PROCOLLAGEN C PROPEPTIDE; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; PYROGLUTAMATE MAGNESIUM; RECOMBINANT ERYTHROPOIETIN; SERMORELIN; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; SPASCUPREEL; TAD 600; TESTIS COMPOSITUM; TESTOSTERONE; TRANSFERRIN RECEPTOR; TRIAMCINOLONE; TROFALGON; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZOLPIDEM TARTRATE;

ACROMEGALY; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); DOPING; DRUG ABUSE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG URINE LEVEL; EVIDENCE BASED MEDICINE; EXERCISE; HEMATOCRIT; HUMAN; REVIEW; TRAINING;

EID: 0345737271     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03345244     Document Type: Review

References (18)

1. Gore CJ, Parisotto R, Ashenden MJ, et al. Second-generation blood tests to detect erythropoietin abuse by athletes. Haematologica 2003, 88: 333-44.
2. Parisotto R, Wu M, Ashenden MJ, et al. Detection of recombinant human erythropoietin abuse in athletes utilizing markers of altered erythropoiesis. Haematologica 2001, 86: 128-37.
3. Castelli G, Famularo A, Semino C, et al. Detection of anti-erythropoietin antibodies in haemodialysis patients treated with recombinant human-erythropoietin. Pharmacol Res 2000, 41: 313-8.
4. Wallace JD, Cueno RC, Bidlingmaier M, et al. Changes in non-22-kilodalton (kDa) isoforms of growth hormone (GH) after administration of 22-kDa recombinant human GH in trained adult males. J Clin Endocrinol Metab 2001, 86: 1731-7.
5. Wallace JD, Cuneo RC, Bidlingmaier M, et al. The response of molecular isoforms of growth hormone to acute exercise in trained adult males. J Clin Endocrinol Metab 2001, 86: 200-6.
6. Schalch DS. The influence of physical stress and exercise on growth hormone and insulin secretion in man. J Lab Clin Med 1967, 69: 256-69.
7. Nguyen UN, Mougin F, Simon-Rigaud ML, Rouillon JD, Marguet P, Regnard J. Influence of exercise duration on serum insulin-like growth factor and its binding proteins in athletes. Eur J Appl Physiol Occup Physiol 1998, 78: 533-7.
8. Chadan, SG, Dill RP, Vanderhoek K, Parkhouse WS. Influence of physical activity on plasma insulin-like growth factor-1 and insulin-like growth factor binding proteins in healthy older women. Mech Ageing Dev 1999, 109: 21-34.
9. De Palo EF, Gatti R, Lancerin F, Cappellin E, Sartorio A, Spinella P. The measurement of insulin-like growth factor-I (IGF-I) concentration in random urine samples. Clin Chem Lab Med 2002, 40: 574-8.
10. De Palo EF, Gatti R, Lancerin F, et al. Urinary insulin-like growth factor I in athletes, before and after physical exercise, and in sedentary subjects. Clin Chim Acta 2002, 322: 51-7.
11. Ehrnborg C, Lange KH, Dall R, et al. The growth hormone/insulin-like growth factor-I axis hormones and bone markers in elite athletes in response to a maximum exercise test. J Clin Endocrinol Metab 2003, 88: 394-401.
12. Wallace JD, Cuneo RC, Baxter R, et al. Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration, and GH withdrawal in trained adult males: A potential test for GH abuse in sport. J Clin Endocrinol Metab 1999, 84: 3591-601.
13. Wallace JD, Cuneo RC, Lundberg PA, et al. Responses of markers of bone and collagen turnover to exercise, growth hormone (GH) administration, and GH withdrawal in trained adult males. J Clin Endocrinol Metab 2000, 85: 124-33.
14. Karila T, Koistinen H, Seppala M, Koistinen R, Seppala T. Growth hormone induced increase in serum IGFBP-3 level is reversed by anabolic steroids in substance abusing power athletes. Clin Endocrinol (Oxf) 1998, 49: 459-63.
15. Kam GY, Leung KC, Baxter RC, Ho KK. Estrogens exert route- and dose-dependent effects on insulin-like growth factor (IGF)-binding protein-3 and the acid-labile subunit of the IGF ternary complex. J Clin Endocrinol Metab 2000, 85: 1918-22.
16. Isley WL, Underwood LE, Clemmons DR. Dietary components that regulate serum somatomedin-C concentrations in humans. J Clin Invest 1983, 71: 175-82.
17. Clemmons DR, Seek MM, Underwood LE. Supplemental essential amino acids augment the somatomedin-C/insulin-like growth factor I response to refeeding after fasting. Metabolism 1985, 34: 391-5.
18. Musey VC, Goldstein S, Farmer PK, Moore PB, Phillips LS. Differential regulation of IGF-I and IGF-binding protein-1 by dietary composition in humans. Am J Med Sci 1993, 305: 131-8.