Identification of a Retinoid Receptor Response Element in the Human Aldehyde Dehydrogenase-2 Promoter

Alcoholism: Clinical and Experimental Research

Volumn 27, Issue 12, 2003, Pages 1860-1866

  Pinaire, Jane ^a   Chou, Wan Yin ^a   Morton, Michael ^a   You, Min ^a   Zeng, Yan ^a   Cho, Won Kyoo ^a   Galli, Andrea ^a   Everett, Lynn ^a   Breen, Heather ^a   Dumaual, Natividad ^a   Smith, Jennifer R ^a   Crabb, David ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Emerson Hall 317 ^*  (United States)

Author keywords

Aldehyde Dehydrogenase; Liver; Receptor; Retinoic Acid; Transcription; Vitamin A

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; CELL NUCLEUS RECEPTOR; METHOPRENE; OLIGONUCLEOTIDE; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA; RETINOID X RECEPTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC TRANSFECTION; HEPATOMA CELL; IN VITRO STUDY; MUTAGENESIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FAMILY; RAT; RECEPTOR BINDING; REPORTER GENE; RETINOID RECEPTOR RESPONSIVE ELEMENT;

ALDEHYDE DEHYDROGENASE; ANIMALS; CELL LINE; HUMANS; MUTATION; PROMOTER REGIONS (GENETICS); RABBITS; RATS; RECEPTORS, RETINOIC ACID; RESPONSE ELEMENTS;

ANIMALIA;

EID: 0345733800     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000100941.86227.4F     Document Type: Article

References (37)

1. Barger PM, Kelly DP (1997) Identification of a retinoid/chicken ovalbumin upstream promoter transcription factor response element in the human retinoid X receptor gamma2 gene promoter. J Biol Chem 272:2722-2728.
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. Castelein H, Janssen A, Declerq PE, Baes M (1996) Sequence requirements for high affinity retinoid X receptor-alpha homodimer binding. Mol Cell Endocrinol 119:11-20.
4. Chan RM, Stewart MJ, Crabb DW (1997) A direct repeat (DR-1) element in the first exon modulates transcription of the preproenkephalin A gene. Brain Res Mol Brain Res 45:50-58.
5. Crabb DW, Dixon JE (1987) A method for increasing the sensitivity of chloramphenicol acetyltransferase assays in extracts of transfected cultured cells. Anal Biochem 163:88-92.
6. Crabb DW, Pinaire J, Chou WY, Sissom S, Peters JM, Harris RA, Stewart M (2001) Peroxisome proliferator-activated receptors (PPAR) and the mitochondrial aldehyde dehydrogenase (ALDH2) promoter in vitro and in vivo. Alcohol Clin Exp Res 25:945-952.
7. Delescluse C, Cavey MT, Martin B, Bernard BA, Reichert U, Maignan J, Darmon M, Shroot B (1991) Selective high affinity retinoic acid receptor alpha or beta-gamma ligands. Mol Pharmacol 40:556-562.
8. Everett LM, Crabb DW (1999) Sensitivity of virally-driven luciferase reporter plasmids to members of the steroid/thyroid/retinoid family of nuclear receptors. J Steroid Biochem Mol Biol 70:197-201.
9. Fischer M, You M, Matsumoto M, Crabb DW (2003) Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem 278:27997-28004.
10. Galli A, Stewart MJ, Dorris R, Crabb DW (1998) High-level expression of RXRalpha and the presence of endogenous ligands contribute to expression of a peroxisome proliferator-activated receptor-responsive gene in hepatoma cells. Arch Biochem Biophys 354:288-294.
11. Giguere V (1999) Orphan nuclear receptors: from gene to function. Endocr Rev 20:689-725.
12. Glass CK (1994) Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocr Rev 15:391-407.
13. Goedde HW, Agarwal DP, Harada S, Meier-Tackmann D, Ruofo D, Bienzle U, Kroeger Hussein L (1983) Population genetic studies on aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity. Am J Hum Genet 35:769-772.
14. Gorman CM, Merlino GT, Willinham MC, Pastan I, Howard BH (1982) The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc Natl Acad Sci USA 79:6777-6781.
15. Hamada K, Gleason SL, Levi BZ, Hirshfeld S, Appella E, Ozato K (1989) H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element. Proc Natl Acad Sci USA 86:8289-8293.
16. Harmon MA, Boehm MF, Heyman RA, Mangelsdorf DJ (1995) Activation of mammalian retinoid X receptors by the insect growth regulator methoprene. Proc Natl Acad Sci USA 92:6157-6160.
17. Huan B, Siddiqui A (1992) Retinoid X receptor RXR alpha binds to and trans-activates the hepatitis B virus enhancer. Proc Natl Acad Sci USA 89:9059-9063.
18. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM (1992) Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (Lond.) 358:771-774.
19. Lebsack ME, Gordon E, Lieber CS (1981) Effect of chronic ethanol consumption on aldehyde dehydrogenase activity in the baboon. Biochem Pharmacol 30:2273-2277.
20. Lee MO, Zhang XK (1995) A retinoic acid response element that overlaps an estrogen response element mediates multihormonal sensitivity in transcriptional activation of the lactoferrin gene. Mol Cell Biol 15: 4194-4207.
21. Lee YK, Dell H, Dowhan DH, Hadzopoulou-Cladaras M, Moore DD (2000) The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. Mol Cell Biol 20:187-195.
22. Leo MA, Lieber CS (1982) Hepatic vitamin A depletion in alcoholic liver injury. N Engl J Med 307:597-601.
23. Liu Y, Chiu JF (1994) Transactivation and repression of the alpha-fetoprotein gene promoter by retinoid X receptor and chicken ovalbumin upstream promoter transcription factor. Nucleic Acids Res 22: 1079-1086.
24. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P (1995) The nuclear receptor superfamily: the second decade. Cell 83:835-839.
25. Nakshatri H, Bhat-Nakshatri P (1998) Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements. Nucleic Acids Res 26:2491-2499.
26. Nordeen SK (1988) Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 6:454-458.
27. Panes J, Soler X, Pares A, Caballeria J, Farres J, Rodes J, Pares X (1989) Influence of liver disease on hepatic alcohol and aldehyde dehydrogenases. Gastroenterology 97:708-714.
28. Pinaire J, Hasanadka R, Fang M, Chou WY, Stewart MJ, Kruijer W, Crabb D (2000) The retinoid X receptor response element in the human aldehyde dehydrogenase 2 promoter is antagonized by the chicken ovalbumin upstream promoter family of orphan receptors. Arch Biochem Biophys 380:192-200.
29. Qian A, Cai Y, Magee TR, Wan YJ (2000) Identification of retinoic acid-responsive elements on the HNFlalpha and HNF4alpha genes. Biochem Biophys Res Commun 276:837-842.
30. Rosenthal N (1987) Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol 152:704-720.
31. Stewart MJ, Dipple KM, Estonius M, Nakshatri H, Everett LM, Crabb DW (1998) Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4. Biochim Biophys Acta 1399:181-186.
32. Takada A, Tsutsumi M, Kobayashi Y (1994) Genotypes of ALDH2 related to liver and pulmonary diseases and other genetic factors related to alcoholic liver disease. Alcoholism 29:719-727.
33. Takase S, Takada A, Yasuhara M, Tsutsumi M (1989) Hepatic aldehyde dehydrogenase activity in liver diseases, with particular emphasis on alcoholic liver disease. Hepatology 9:704-709.
34. Tsai SY, Tsai MJ (1997) Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocrine Rev 18: 229-240.
35. Yokoyama A, Muramatsu T, Ohmori T, Higuchi S, Hayashida M, Ishii H (1996) Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males. Cancer Epidemiol Biomarkers Prev 5:99-102.
36. Zhang XK, Hoffmann B, Tran PB, Graupner G, Pfahl M (1992a) Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature (Lond.) 355:441-446.
37. Zhang XK, Lehmann J, Hoffmann B, Dawson MI, Cameron J, Graupner G, Hermann T, Tran P, Pfahl M (1992b) Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid. Nature (Lond.) 358:587-591.