Antipyretic Efficacy and Safety of Ibuprofen and Acetaminophen in Children

Annals of Pharmacotherapy

Volumn 38, Issue 1, 2004, Pages 146-150

  Goldman, Ran D ^a   Ko, Karen ^a   Linett, Lauren J ^a   Scolnik, Dennis ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Acetaminophen; Children; Ibuprofen

Indexed keywords

ANTIPYRETIC AGENT; IBUPROFEN; PARACETAMOL;

ABDOMINAL PAIN; AGITATION; ANAPHYLAXIS; CHILD; COMPARATIVE STUDY; DRUG ADMINISTRATION; DRUG EFFICACY; DRUG SAFETY; FEVER; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL SYMPTOM; HUMAN; HYPOTHERMIA; INFANT; KIDNEY FAILURE; MULTIPLE DRUG DOSE; NERVOUSNESS; PRESCHOOL CHILD; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SINGLE DRUG DOSE; TIME; VOMITING;

EID: 0345731430     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1C391     Document Type: Review

References (24)

1. Van der Jagt EW. Feven In: Hoekelman RA, ed. Primary pediatric care. 3rd ed. St Louis: Mosby, 1997:959-66.
2. Walson PD, Galletta G, Braden NJ, Alexander L. Ibuprofen, acetaminophen and placebo treatment of febrile children. Clin Pharmacol Ther 1989;46:9-17.
3. Behrman RE, Kliegman RM, Jenson HB, eds. Nelson textbook of pediatrics. 16th ed. Philadelphia: WB Saunders, 2000:736-8.
4. Crocetti M, Moghbeli N, Serwint J. Fever phobia revisited: have parental misconceptions about fever changed in 20 years? Pediatrics 2001;107:1241-6.
5. Thomas V, Riegel B, Andrea J, Murray P, Gerhart A, Gocka I. National survey of pediatric fever management practices among emergency department nurses. J Emerg Nurs 1994;20:505-10.
6. Purssell E. Treating fever in children: paracetamol or ibuprofen? Br J Commun Nurs 2002;7:316-20.
7. Committee on Infectious Diseases. Aspirin and Reye syndrome. Pediatrics 1982;69:810-2.
8. American Academy of Pediatrics. Acetaminophen toxicity in children. Pediatrics 2001;108:1020-4.
9. Walson PD, Galletta G, Chomilo F, Braden NJ, Sawyer LA, Scheinbaum ML. Comparison of multidose ibuprofen and acetaminophen therapy in febrile children. Am J Dis Child 1992;146:626-32.
10. Sheth UK, Gupta K, Paul T, Pispati PK. Measurement of antipyretic activity of ibuprofen and paracetamol in children. J Clin Pharmacol 1980;20:672-5.
11. Autret E, Reboul-Marty J, Henry-Launois B, Laborde C, Courcier S, Goehrs JM, et al. Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever. Eur J Clin Pharmacol 1997;51:367-71.
12. Vauzelle-Kervroedan F, d'Athis P, Pariente-Khayat A, Debregeas S, Olive G, Pons G. Equivalent antipyretic activity of ibuprofen and paracetamol in febrile children. J Pediatr 1997;131:683-7.
13. Sidler J, Frey B, Baerlocher K. A double-blind comparison of ibuprofen and paracetamol in juvenile pyrexia. Br J Clin Pract Suppl 1990;70:22-5.
14. Amdekar YK, Desai RZ. Antipyretic activity of ibuprofen and paracetamol in children with pyrexia. Br J Clin Pract 1985;39:140-3.
15. Kauffman RE, Sawyer LA, Scheinbaum ML. Antipyretic efficacy of ibuprofen vs acetaminophen. Am J Dis Child 1992;146:622-5.
16. McIntyre J, Hull D. Comparing efficacy and tolerability of ibuprofen and paracetamol in fever. Arch Dis Child 1996;74:164-7.
17. Wilson JT, Brown RD, Kearns GL, Eichler VF, Johnson VA, Bertrand KM, et al. Single-dose, placebo-controlled comparative study of ibuprofen and acetaminophen antipyresis in children. J Pediatr 1991;119:803-11.
18. Wong A, Sibbald A, Ferrero F, Plager M, Santolaya ME, Escobar AM, et al. Antipyretic effects of dipyrone versus ibuprofen versus acetaminophen in children: results of a multinational, randomized, modified double-blind study. Clin Pediatr (Phila) 2001;40:325-6.
19. Wilson G, Guerra AJ, Santos NT. Comparative study of the antipyretic effect of ibuprofen (oral suspension) and paracetamol (suppositories) in paediatrics. J Int Med Res 1984;12:250-4.
20. Simila S, Kouvalainen K, Keinanen S. Oral antipyretic therapy. Scand J Rheumatol 1976;5:81-3.
21. Joshi YM, Sovani VB, Joshi VV, Navrange JR, Benakappa DG, Shivananda P, et al. Comparative evaluation of the antipyretic efficacy of ibuprofen and paracetamol. Indian Pediatr 1990;27:803-6.
22. Lesko SM, Mitchell AA. The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics 1999;104:e39.
23. Meremikwu M, Oyo-Ita A. Paracetamol for treating fever in children. Cochrane Rev 2002;(2):CD003676.
24. Lesko SM, Mitchell AA. An assessment of the safety of pediatric ibuprofen. A practitioner-based randomized clinical trial. JAMA 1995;273:929-33.