General pharmacological properties of the new proton pump inhibitor (±)-5-methoxy-2-[[(4-methoxy-3,5-dimethylpyrid-2-yl)methyl] sulfinyl]-1H- imidazo[4,5-b]pyridine

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 21, Issue 3, 1999, Pages 179-187

  Kakinoki, Bunpei ^a   Chizuko, Ono ^b   Yamazaki, Noriyuki ^b   Chikamatsu, Noriko ^b   Wakatsuki, Daisuke ^a   Uchiyama, Kazuyuki ^a   Morinaka, Yasuhiro ^a  

^a Kazusa Research Laboratories   (Japan)

^b New Drug Devmt Res Center Inc   (Japan)

Author keywords

General pharmacology; Proton pump inhibitor; TU 199

Indexed keywords

5 METHOXY 2 [[(4 METHOXY 3,5 DIMETHYLPYRID 2 YL)METHYL]SULFINYL] 1H IMIDAZO[4,5 B]PYRIDINE; BENATOPRAZOLE; PENTETRAZOLE; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CENTRAL NERVOUS SYSTEM FUNCTION; DRUG EFFECT; GASTROINTESTINAL DISEASE; GUINEA PIG; INTESTINE FUNCTION; KIDNEY FUNCTION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PEPTIC ULCER; RAT; WRITHING TEST;

ANIMALS; ANTI-ULCER AGENTS; DOGS; GUINEA PIGS; ILEUM; IMIDAZOLES; MALE; MICE; MOTOR ACTIVITY; OMEPRAZOLE; PROTON PUMPS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SEIZURES;

EID: 0345711484     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.1999.21.3.534827     Document Type: Article

References (7)

1. +)-ATPase within the parietal cell. Biochim Biophys Acta 1984, 778: 549-58.
2. +)-adenosine triphosphatase by the proton pump inhibitor AG-1749. J Pharmacol Exp Ther 1989, 284: 799-805.
3. Larsson, H., Carlsson, E., Junggren, U., Olbe, L., Sjostrand S.E., Skanberg, I., Sundell, G. Inhibition of gastric acid secretion by omeprazole in the dog and rat. Gastroenterology 1983, 85: 900-7.
4. Konturek, S.J., Cieszkowski, M., Kwiecien, N., Konturek, J., Tasler, J., Bilski, J. Effects of omeprazole, a substituted benzimidazole, on gastrointestinal secretions, serum gastrin, and gastric mucosal blood flow in dogs. Gastroenterology 1984, 86: 71-7.
5. Irwin, S. Drug screening and evaluative procedures: Current approaches do not provide the information needed properly predicting drug effects in man. Science 1962, 136: 123-8.
6. Nishimori, T., Morino, K., Nishimura, T. et al. General pharmacology of omeprazole. Clin Rep 1988, 22: 219-37.
7. Okabe, S. Effects of gastric proton pump inhibitor on gastric secretion and peptic ulcers. Folia Pharmacol Japon 1986, 87: 351-60.