Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin

Journal of Pathology

Volumn 199, Issue 4, 2003, Pages 509-516

  Reichrath, Jörg ^a   Welter, Cornelius ^a   Mitschele, Tanja ^a   Classen, Ulf ^a   Meineke, Viktor ^b   Tilgen, Wolfgang ^a   Seifert, Markus ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Sanitatsakademie der Bundeswehr   (Germany)

Author keywords

Basal cell carcinoma; Calpain; Cancer; LightCycler; Skin; Squamous cell carcinoma

Indexed keywords

CALCIUM ION; CALPAIN; INTEGRIN; ISOENZYME; MESSENGER RNA; PEROXIDASE; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE C; PROTEIN KINASE P60; PROTEIN P53; PROTEINASE; STREPTAVIDIN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BASAL CELL CARCINOMA; CANCER GROWTH; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; FEEDBACK SYSTEM; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; LYSOSOME; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA;

EID: 0345701372     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1308     Document Type: Article

References (37)

1. Croall DE, Demartino GN. Calcium-activated neutral protease (calpain) system: structure, function, and regulation. Physiol Rev 1991; 71: 813-847.
2. Sorimachi H, Ishiura S, Suzuki K. Structure and physiological function of calpains. Biochem J 1997; 328: 721-732.
3. Crawford C, Brown NR, Willis AC. Studies of the active site of m-calpain and the interaction with calpastatin. Biochem J 1993; 296: 135-142.
4. Kuboki M, Ishii H, Horie S, Kazama M. Procalpain I in cytoplasm is translocated onto plasma and granule membranes during platelet stimulation with thrombin and then activated on the membranes. Biochem Biophys Res Commun 1992; 185: 1122-1127.
5. Saido TC, Sorimachi H, Suzuki K. Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J 1994; 8: 814-822.
6. Lane RD, Allan DM, Mellgren RL. A comparison of the intracellular distribution of u-calpain, m-calpain and calpastatin in proliferating human A431 cells. Exp Cell Res 1992; 203: 5-16.
7. Miyachi Y, Yoshimura N, Suzuki S, et al. Biochemical demonstration and immunohistochemical localization of calpain in human skin. J Invest Dermatol 1986; 86: 346-349.
8. Bikle DD, Pillai S. Vitamin D, calcium and epidermal differentiation. Endocr Rev 1993; 14: 3-19.
9. 2+ in the second stage. J Biol Chem 1993; 268: 25 139-25 145.
10. Nagao S, Saido TC, Akita Y, Tsuchiya T, Suzuki K, Kawashima S. Calpain-calpastatin interactions in epidermoid carcinoma KB cells. J Biochem 1994; 115: 1178-1184.
11. Potts AJ, Croall DE, Hemler ME. Proteolytic cleavage of the integrin b4 subunit. Exp Cell Res 1994; 212: 2-9.
12. Sato N, Fujio Y, Yamada-Honda F, et al. Elevated calcium level induces calcium-dependent proteolysis of A-CAM (N-cadherin) in heart: analysis by detergent treated model. Biochem Biophys Res Commun 1995; 217: 649-653.
13. Hodivala KJ, Watt FM. Evidence that cadherins play a role in the downregulation of integrins expression that occurs during keratinocyte terminal differentiation. J Cell Biol 1994; 124: 589-600.
14. Inomata M, Hayashi M, Ohno-Iwashita Y, Tsubuki S, Saido TC, Kawashima S. Involvement of calpain in integrin-mediated signal transduction. Arch Biochem Biophys 1996; 328: 129-134.
15. Gates RE, King LE. Calcium facilitates endogenous proteolysis of the EGF-receptor-kinase. Mol Cell Endocrinol 1982; 27: 263-276.
16. King LE, Gates RE. Calcium-activated neutral protease purified from beef lung: properties and use defining structure of epidermal growth factor receptor. Arch Biochem Biophys 1985; 242: 146-156.
17. Yoshimura N, Tsukahara I, Murachi T. Calpain and calpastatin in porcine retina. Biochem J 1984; 223: 47-51.
18. Kishimoto A, Kajaikawa N, Shiota M, Nishizuka Y. Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease. J Biol Chem 1983; 258: 1156-1164.
19. 2+ -dependent, sulfhydryl-sensitive proteolytic system in A431 cells. J Biol Chem 1982; 257: 9845-9848.
20. Bodwell JE, Halbrook NJ, Munck A. Stabilization of thymic glucocorticoid-receptor complexes by the calcium activated protease inhibitor, calpastatin. J Biol Chem 1985; 260: 2601-2604.
21. Watt F, Molloy PL. Specific cleavage of transcription factors by the thiol protease, m-calpain. Nucleic Acids Res 1993; 21: 5092-5100.
22. Garach-Jehoshua O, Ravid A, Liberman UA, Reichrath J, Glaser T, Koren R. Upregulation of the calcium dependent protease calpain during keratinocyte differentiation. Br J Dermatol 1998; 139: 950-957.
23. Braun C, Engel M, Seifert M, et al. Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type. Int J Cancer 1999; 84: 6-9.
24. Chomczynski P, Sacchi N. Single step method of RNA isolation by guanidium-thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
25. Sachs L. Angewandte Statistik. Springer: Berlin, 1997; ch. 394.
26. Kim SY, Bae CD. Calpain inhibitors reduce the cornified cell envelope formation by inhibiting proteolytic processing of transglutaminase 1. Exp Mol Med 1998; 30(4): 257-262.
27. Yamazaki M, Ishidoh K, Suga Y, et al. Cytoplasmic processing of human profilaggrin by active mu-calpain. Biochem Biophys Res Commun 1997; 235(3): 652-656.
28. Huttenlocher A, Palecek SP, Lu Q, et al. Regulation of cell migration by the calcium dependent protease calpain. J Biol Chem 1997; 272: 32 719-32 722.
29. Baum HP, Schmid T, Reichrath J. Integrin molecules: a clue to the non-metastasizing behaviour of basal cell carcinomas? Acta Derm Venereol 1996; 76(1): 24-27.
30. Mooney EE, Ruis Peris JM, O'Neil A, Sweeney EC. Apoptotic and mitotic indices in malignant melanoma and basal cell carcinoma. J Clin Pathol 1995; 48: 242-244.
31. Carafoli E, Molinari M. Calpain: a protease in search of a function? Biochem Biophys Res Commun 1998; 247: 193-203.
32. Ono Y, Sorimachi H, Suzuki K. Structure and physiology of calpain, an enigmatic protease. Biochem Biophys Res Commun 1998; 245: 289-294.
33. Gonen H, Shkedy D, Barnoy S, Kosower NS, Ciechanover A. On the involvement of calpains in the degradation of the tumour suppressor protein p53. FEBS Lett 1997; 406: 17-22.
34. Pariat M, Carillo S, Molinari M, et al. Proteolysis by calpains: a possible contribution to degradation of p53. Mol Cell Biol 1997; 17: 2806-2815.
35. Atencio I, Ramachandra M, Shabram P, Demers G. Calpain inhibitor 1 activates p53-dependent apoptosis in tumour cell lines. Cell Growth Differ 2000; 11: 247-253.
36. Hiwasa T, Arase Y, Kikuno K, et al. Increase in ultraviolet sensitivity by overexpression of calpastatin in ultraviolet-resistant UVr-1 cells derived from ultraviolet-sensitive human RSa cells. Cell Death Differ 2000; 7: 531-537.
37. Benetti R, Del Sal G, Monte M, et al. The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis. EMBO J 2001; 20: 2702-2714.