Inhibition of liver cell proliferation by dexamethasone does not prevent tumor induction by ciprofibrate in the rat liver

Hepatology Research

Volumn 12, Issue 1, 1998, Pages 12-22

  Sambasiva Rao, M ^a   Subbarao, V ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Hepatocellular carcinoma; Nongenotoxic carcinogens; Oxidative stress; Peroxisomes

Indexed keywords

CIPROFIBRATE; DEXAMETHASONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CARCINOGENICITY; CELL PROLIFERATION; CONTROLLED STUDY; LIPID PEROXIDATION; LIVER CARCINOGENESIS; LIVER CELL CULTURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0345698777     PISSN: 09284346     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1386-6346(98)00036-9     Document Type: Article

References (40)

1. Rao MS, Reddy JK Hepatocarcinogenesis of peroxisome proliferators. An NY Acad Sci. 804:1996;573-587.
2. Reddy JK, Lalwani ND Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plastisizers to humans. Crit Rev Toxicol. 12:1983;1-58.
3. Reddy JK, Scarpelli DG, Subbarao V, Lalwani ND Chemical carcinogens without mutagenic activity: peroxisome proliferators as a prototype. Toxicol Pathol. 11:1983;172-180.
4. 32p-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro. Carcinogenesis. 6:1985;933-936.
5. Elliott BM, Dodd NJF, Elcombe CR Increased hydroxyl radical production in liver peroxisomal fractions from rats treated with peroxisome proliferators. Carcinogenesis. 7:1986;195-199.
6. Tomaszewski KE, Agarwal DK, Melnick RL In-vitro steady-state levels of hydrogen peroxide after exposure of male F344 rats and B6C3F1 mice to hepatic peroxisome proliferators. Carcinogenesis. 7:1986;1871-1876.
7. Reddy JK, Rao MS Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis. Mutat Res. 214:1989;63-68.
8. Rao MS, Reddy JK Toxicological implications of peroxisome proliferation. Meeks R, Harrison S, Bull R Hepatotoxicology. 1991;621-646 CRC Press, Boca Raton.
9. Butterworth BE, Loury DJ, Smith-Oliver T, Cattley RS The potential role of chemically induced hyperplasia in the carcinogenic activity of the hypolipidemic carcinogens. Toxicol Ind Health. 3:1987;129-146.
10. Rao MS, Subbarao V Effect of dexamethasone on ciprofibrate-induced cell proliferation and peroxisome proliferation. Fundam Appl Toxicol. 35:1997;78-83.
11. Theunissen PHMH, Leers MPG, Bollen ECM Proliferating cell nuclear antigen (PCNA) expression in formalin fixed tissue of non-small cell lung carcinoma. Histopathology. 20:1992;251-255.
12. Chomczynski P, Sacchi N Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
13. Nemali MR, Usuda N, Reddy MK et al. Comparision of constitutive and inducible levels of expression of peroxisomal β-oxidation and catalase genes in liver and extrahepatic tissues of rat. Cancer Res. 48:1988;5316-5324.
14. Rao MS, Lalwani ND, Watanabe TK, Reddy JK Inhibitory effect of antioxidant ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator. Cancer Res. 44:1984;1072-1076.
15. Rao MS, Lalwani ND, Reddy JK Sequential histologic study of rat liver during peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (wy-14,643)-induced carcinogenesis. J Natl Cancer Inst. 73:1984;983-990.
16. Ames BN, Gold LS Too many rodent carcinogens: mitogenesis increases mutagenesis. Science. 240:1990;970-971.
17. Grasso P Peroxisome proliferation and hepatotoxicity in rodents. Biochem Soc Trans. 31:1985;861-862.
18. Marsman DS, Cattley RC, Conway JG, Popp JA Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenecity of peroxisome proliferators di (2-ethylhexyl) phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinyl thio] acetic acid (wy-14,643) in rats. Cancer Res. 48:1988;6739-6744.
19. 3H]thymidine administered by injection or osmotic pump. Carcinogenesis. 11:1990;2245-2251.
20. Kurki P, Vanderlaan M, Dolbeare F, Gray J, Tan M Expression of proliferating cell nuclear antigen (PCNA/cyclin) during the cell cycle. Exp Cell Res. 166:1986;209-219.
21. Kamel OW, LeBrun DP, Davis RE, Berry GJ, Warnke RA Growth fraction estimation of malignant lymphomas in formalin-fixed paraffin-embedded tissue using anti-PCNA cyclin 19A2. Am J Pathol. 138:1991;1471-1477.
22. Eldridge SR, Butterworth BE, Goldsworthy TL Proliferating cell nuclear antigen: a marker for hepatocellular proliferation in rodents, Env Health Persp ;! Environ Health Perspect (suppl 5). 1:1993;211-218.
23. Allegranza A, Girlando S, Arrogoni GL et al. Proliferating cell nuclear antigen expression in central nervous system neoplasms. Virch A Pathol Anat. 419:1991;417-423.
24. Ledda-Columbano GM, Columbano A, Cannas A et al. Dexamethasone inhibits induction of liver tumor necrosis factor-α mRNA and liver growth induced by lead nitrate and ethylene dibromide. Am J Pathol. 145:1994;951-958.
25. Ehlvest J, Veidebaum T, Poldvere E Role of mitotic activity in target tissues. Tursov V, Montesano R Modulators of Experimental Carcinogenesis. 51:1983;295-301 IARC Scientific Publications, Lyon.
26. Slaga J, Thompson S, Smuckler E Prolonged inhibition of mouse epidermal DNA synthesis by dexamethasone. J Natl Cancer Inst. 54:1975;931-936.
27. Lemberger T, Stales B, Saladin R, Desvergne B, Auwerx J, Wahli W Regulation of the peroxisome proliferator-activated receptor α gene by glucocorticoids. J Biol Chem. 269:1994;24527-24530.
28. Lee SS, Pineau T, Drago J et al. Targeted disruption of the α-isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol. 15:1995;3012-3022.
29. cip1. Mol Endocrinol. 11:1977;577-586.
30. Reisman D, Thompson EA Glucocorticoid regulation of cyclin D, 3 gene transcription, mRNA stability in lymphoid cells. Mol Endocrinol. 9:1995;1500-1509.
31. Slaga TJ, Scribner JD Inhibition of tumor initiation and promotion by antiinflammatory agents. J Natl Cancer Inst. 51:1973;1723-1725.
32. Rao MS, Subbarao V, Yeldandi AV, Reddy JK Hepatocarcinogenicity of dehydroepiandrosterone in the rat. Cancer Res. 52:1992;2977-2979.
33. Hayashi F, Tamura H, Yamada J, Kasai H, Suga T Characteristics of the hepatocarcinogenesis caused by dehydroepiandrosterone, a peroxisome proliferator, in male F-344 rats. Carcinogenesis. 15:1994;2215-2219.
34. Metzger C, Mayer D, Hoffmann H, Bocker T, Hobe G, Benner A, Bannasch P Sequential appearance and ultrastructure of amphophilic cell foci, adenomas, and carcinomas in the liver of male and female rats treated with dehydroepiandrosterone. Toxicol Pathol. 23:1995;591-605.
35. Borges T, Peterson RE, Pitot HC, Robertson LW, Glauert HP Effect of the peroxisome proliferator perfluorodecanoic acid on the promotion of two-stage hepatocarcinogenesis in rats. Cancer Lett. 72:1993;111-120.
36. Yeldandi AV, Milano M, Subbarao V, Reddy JK, Rao MS Evaluation of liver cell proliferation during ciprofibrate-induced hepatocarcinogenesis. Cancer Lett. 47:1993;21-27.
37. Lalwani ND, Reddy MK, Qureshi SA, Moehle CM, Hayashi H, Reddy JK Noninhibitory effect of antioxidants ethoxyquin, 2(3)-tert-butyl-4-hydroxyanisole and 3,5-di-tert-butyl-4-hydroxytoluene on hepatic peroxisome proliferation and peroxisomal fatty acid β-oxidation induced by a hypolipidemic agent in rats. Cancer Res. 43:1983;1680-1687.
38. Ledda-Columbano GM, Coni P, Curto P et al. Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis. Carcinogenesis. 13:1992;379-383.
39. Columbano A, Ledda-Columbano GM, Curto M et al. Further evidence that mitogen-induced cell proliferation does not support the formation of enzyme altered islands in rat liver by carcinogens. Cancer Res. 47:1987;5557-5559.
40. Cayama E, Tsuda H, Sarma DSR, Farber E Initiation of chemical carcinogenesis require cell proliferation. Nature. 275:1978;60-62.