Characterization of [11C]vorozole binding in ovarian tissue in rats throughout estrous cycle in association with conversion of androgens to estrogens in vivo and in vitro

Steroids

Volumn 68, Issue 14, 2003, Pages 1139-1146

  Kirilovas, Dmitrijus ^a   Naessen, Tord ^a   Bergström, Mats ^a   Bergström Petterman, Elizabeth ^a   Carlström, Kjell ^b   Långström, Bengt ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Aromatase; Estrous cycle; Ovary; Positron emission tomography; Rat; Vorozole

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; AROMATASE; CARBON 11; ESTRADIOL; ESTROGEN; TRACER; VOROZOLE; AROMATASE INHIBITOR; ENZYME INHIBITOR; LUTEINIZING HORMONE; TRIAZOLE DERIVATIVE;

ANDROSTENEDIONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SPECIFICITY; ESTRADIOL BLOOD LEVEL; ESTROGEN SYNTHESIS; ESTRUS CYCLE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OVARY; PROESTRUS; RAT; TISSUE HOMOGENATE; ANIMAL; BINDING SITE; BLOOD; ESTRUS; METABOLISM; PHYSIOLOGY; RADIOIMMUNOASSAY; SPRAGUE DAWLEY RAT;

ANDROSTENEDIONE; ANIMALS; AROMATASE; AROMATASE INHIBITORS; BINDING SITES; ENZYME INHIBITORS; ESTRADIOL; ESTROUS CYCLE; ESTRUS; FEMALE; LUTEINIZING HORMONE; OVARY; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; TRIAZOLES;

EID: 0345687916     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2003.08.013     Document Type: Article

References (36)

1. Hillier S.G., van den Boogaard A.M., Reichert L.E. Jr., van Hall E.V. Alterations in granulosa cell aromatase activity accompanying preovulatory follicular development in the rat ovary with evidence that 5alpha-reduced C19 steroids inhibit the aromatase reaction in vitro. J. Endocrinol. 84:1980;409.
2. Hillier S.G., Zeleznik A.J., Knazek R.A., Ross G.T. Hormonal regulation of preovulatory follicle maturation in the rat. J. Reprod. Fertil. 60:1980;219.
3. Butcher R.L., Collins W.E., Fugo N.W. Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17beta throughout the 4-day estrous cycle of the rat. Endocrinology. 94:1974;1704.
4. Dupon C., Kim M.H. Peripheral plasma levels of testosterone, androstenedione, and oestradiol during the rat oestrous cycle. J. Endocrinol. 59:1973;653.
5. Belanger A., Cusan L., Caron S., Barden N., Dupont A. Ovarian progestins, androgens and estrogen throughout the 4-day estrous cycle in the rat. Biol. Reprod. 24:1981;591.
6. Blake C.A. A detailed characterization of the proestrous luteinizing hormone surge. Endocrinology. 98:1976;445.
7. Fitzpatrick S.L., Richards J.S. Regulation of cytochrome P450 aromatase messenger ribonucleic acid and activity by steroids and gonadotropins in rat granulosa cells. Endocrinology. 129:1991;1452.
8. Zimniski S.J., Brandt M.E., Covey D.F., Puett D. Inhibition of aromatase activity and of endocrine-responsive tumor growth by 10-propargylestr-4-ene-3, 17-dione and its 17-propionate derivative. Steroids. 50:1987;135.
9. Whitelaw P.F., Smyth C.D., Howles C.M., Hillier S.G. Cell-specific expression of aromatase and LH receptor mRNAs in rat ovary. J. Mol. Endocrinol. 9:1992;309.
10. Lephart E.D., Doody K.J., McPhaul M.J., Simpson E.R. Inverse relationship between ovarian aromatase cytochrome P450 and 5alpha-reductase enzyme activities and mRNA levels during the estrous cycle in the rat. J. Steroid Biochem. Mol. Biol. 42:1992;439.
11. Suzuki K., Tamaoki B.I. Postovulatory decrease in estrogen production is caused by the diminished supply of aromatizable androgen to ovarian aromatase. Endocrinology. 107:1980;2115.
12. Hickey G.J., Chen S.A., Besman M.J., Shively J.E., Hall P.F., Gaddy-Kurten D.et al. Hormonal regulation, tissue distribution, and content of aromatase cytochrome P450 messenger ribonucleic acid and enzyme in rat ovarian follicles and corpora lutea: relationship to estradiol biosynthesis. Endocrinology. 122:1988;1426.
13. Doody K.J., Lephart E.D., Stirling D., Lorence M.C., Magness R.R., McPhaul M.J.et al. Expression of mRNA species encoding steroidogenic enzymes in the rat ovary. J. Mol. Endocrinol. 6:1991;153.
14. Brandt M.E., Puett D., Zimniski S.J. Divergence between ovarian aromatase activity, estrogen, and androgen levels in the cycling rat. Endocrinology. 126:1990;72.
15. Wouters W., Snoeck E., De Coster R. Vorozole, a specific non-steroidal aromatase inhibitor. Breast Cancer Res. Treat. 30:1994;89.
16. Koymans L.M., Moereels H., Vanden Bossche H. A molecular model for the interaction between vorozole and other non-steroidal inhibitors and human cytochrome P450 19 (P450 aromatase). J. Steroid Biochem. Mol. Biol. 53:1995;191.
17. Johnston S.R., Smith I.E., Doody D., Jacobs S., Robertshaw H., Dowsett M. Clinical and endocrine effects of the oral aromatase inhibitor vorozole in postmenopausal patients with advanced breast cancer. Cancer Res. 54:1994;5875.
18. de Jong P.C., van de Ven J., Nortier H.W., Maitimu-Smeele I., Donker T.H., Thijssen J.H.et al. Inhibition of breast cancer tissue aromatase activity and estrogen concentrations by the third-generation aromatase inhibitor vorozole. Cancer Res. 57:1997;2109.
19. 11C ]vorozole binding assay Steroids. 64:1999;266.
20. Kirilovas D. Regulation of ovarian aromatase: studies by aromatase assays in vitro and in vivo. Thesis. Uppsala University: Uppsala; 2003.
21. 11C ]vorozole Nucl. Med. Biol. 25:1998;497.
22. Newton C.J., Samuel D.L., James V.H. Aromatase activity and concentrations of cortisol, progesterone and testosterone in breast and abdominal adipose tissue. J. Steroid Biochem. 24:1986;1033.
23. 11C -vorozole binding in granulosa cells in vitro Acta Obstet. Gynecol. Scand. 82:2003;209.
24. Agarwal S.K., Judd H.L., Magoffin D.A. A mechanism for the suppression of estrogen production in polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 81:1996;3686.
25. Miyamura K., Ogawa T., Narahara H., Mori H., Kigawa T. Non-steroidal low molecular substance from porcine follicular fluid inhibits aromatase activity. Asia Oceania J. Obstet. Gynaecol. 15:1989;359.
26. Kigawa T., Ogawa T., Miyamura K., Iino Y. Inhibitory activity of a low molecular weight substance extracted from porcine small follicular fluid on estradiol and progesterone secretions by rat granulosa cells in vitro and by rat ovaries in vivo. Endocrinol. Jpn. 33:1986;597.
27. Schreiber J.R., diZerega G.S. Porcine follicular fluid protein(s) inhibit rat ovary granulosa cell steroidogenesis. Am. J. Obstet. Gynecol. 155:1986;1281.
28. Uzumcu M., Lin Y.C. Characterization of the stimulatory actions of thymic factor(s) on basal and gonadotropin-induced steroidogenesis in cultured rat granulosa cells. Mol. Cell. Endocrinol. 105:1994;209.
29. Uzumcu M., Brigstock D.R., Lin Y.C. Partial purification and characterization of two non-FSH steroid-modulating factors in rat thymic epithelial cell-conditioned medium (TCM). Domest. Anim. Endocrinol. 15:1998;155.
30. Miro F., Smyth C.D., Hillier S.G. Development-related effects of recombinant activin on steroid synthesis in rat granulosa cells. Endocrinology. 129:1991;3388.
31. Liang S.G., Taketani Y., Yano T., Mizuno M. Regulation of aromatase activity by gonadotropin-releasing hormone and its agonists in cultured rat granulosa cells. Nippon Sanka Fujinka Gakkai Zasshi. 41:1989;1725.
32. Saragueta P., Krimer A.R., Charreau E.H., Tesone M. Insulin regulation of steroidogenic activity in rat culture luteal cells. J. Steroid Biochem. 32:1989;393.
33. Dodson K.S., Watson J. Stimulatory action of prostaglandin F2 alpha on androgen aromatization in the pig follicle. Eur. J. Obstet. Gynecol. Reprod. Biol. 11:1980;49.
34. Davoren J.B., Hsueh A.J. Vasoactive intestinal peptide: a novel stimulator of steroidogenesis by cultured rat granulosa cells. Biol. Reprod. 33:1985;37.
35. Simpson E.R., Zhao Y., Agarwal V.R., Michael M.D., Bulun S.E., Hinshelwood M.M.et al. Aromatase expression in health and disease. Recent Prog. Horm. Res. 52:1997;185.
36. Fujii T., Hoover D.J., Channing C.P. Changes in inhibin activity, and progesterone, oestrogen and androstenedione concentrations, in rat follicular fluid throughout the oestrous cycle. J. Reprod. Fertil. 69:1983;307.