Effect of stobadine on human stimulated polymorphonuclear leukocytes

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 21, Issue 2, 1999, Pages 75-78

  Drábiková, Katarína ^a   Pecivova J ^a   Macickova T ^a   Kotuliakova K ^a   Nosal R ^a   Danihelova E ^b  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b Inst Haematol and Transfusiology   (Slovakia)

Author keywords

3 H arachidonic acid liberation; A 23187; Calcium ionophore; Human polymorphonuclear leukocytes; N formyl methionyl leucyl phenylalanine; Stobadine; Superoxide generation; Glucuronidase release

Indexed keywords

ARACHIDONIC ACID; BETA GLUCURONIDASE; CALCIMYCIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; STOBADINE; SUPEROXIDE;

ARACHIDONIC ACID METABOLISM; ARTICLE; CELL ACTIVATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME RELEASE; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; SIGNAL TRANSDUCTION;

EID: 0345683496     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.1999.21.2.529232     Document Type: Article

References (16)

1. Beneš, L., Štolc, S. Stobadine. Drugs Fut 1989, 14:135-7.
2. Štolc, S., Vlkolinský, R., Pavlásek J. Neuroprotection by pyridoindole stobadine: A minireview. Brain Res Bull 1997, 42: 335-40.
3. Smith, J.A. Neutrophils, host defense, and inflammation: a double-edged sword. J Leukoc Biol 1994, 56: 672-86.
4. Boyum, M. Isolation of mononuclear cells and granulocyles from human blood. Scand J Clin Lab Invest 1968, 21:77-90.
5. Babior, B.M., Kipnes, R.S., Curnutte, J.T. Biological defense Mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest 1973, 52:741-4.
6. Fishman, W.H. Beta-glucuronidase. In: Methods of Enzymatic Analysis. Bergmeyer, H.U. (Ed.). Academic press: New York 1965, 869-94.
7. 2 for activation of the assembled NADPH oxidase in human neutrophils. Biochem J 1994, 297: 217-23.
8. Jancinová, V., Nosál', R. Difference among beta adrenoceptor blocking drugs in modifying platelet aggregation and arachidonic acid liberation under thrombin stimulation. Thromb Res 1989, 54:687-98.
9. 1 analog misoprostol. J Rheumatol 1991, 18: 1461-5.
10. Shaafi, R.I., Molski, T.F.P. Activation of the neutrophil. Prog Allergy 1988, 42: 1-64.
11. Štefek, M., Beneš, L. Pyridoindole stobadine is a potent scavenger of hydroxyl radicals. FEBS Lett 1991, 294:246-66.
12. Horáková, L., Sies, H., Steenken, S. Antioxidant action of stobadine. Methods Enzymol 1994, 234: 572-80.
13. Pecivová, J., Kotuliaková, K., Macieková, T., Drábiková K., Nosál', R. Effect of stobadine on free radical generation in stimulated human polymorphonuclear leukocytes. Life Sci 1998, in press.
14. Jancinová, V., Nosál', R., Danihelová , E. Aggregation of human blood platelets in the presence of the pyridoindole stobadine. Life Sci 1998, in press.
15. Abramson, S.B., Leszczynska-Piziak, J., Weissmann, G. Arachidonic acid as a second messenger. Interactions with a GTP-binding Protein of Human Neutrophils. J Immunol 1991, 147: 231.
16. Smith, C.D., Cox, C.C., Snyderman, R. Receptor-coupled activation of phospho-inositide specific phospholipase C by a nucleotide binding protein. Science 1986, 232: 97-9.