Abnormalities of the urokinase system in colonie crypt cells from patients with ulcerative colitis

Inflammatory Bowel Diseases

Volumn 2, Issue 2, 1996, Pages 105-114

  Gibson, Peter R ^a   Rosella, Ourania ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Colon; Crohn's disease; Epithelium; Plasminogen activator inhibitors; Plasminogen activators; Ulcerative colitis; Urokinase; Urokinase receptor

Indexed keywords

EID: 0345680960     PISSN: 10780998     EISSN: None     Source Type: Journal    
DOI: 10.1002/ibd.3780020206     Document Type: Article

References (41)

1. Roediger WEW. The colonic epithelium in ulcerative colitis: an energy deficiency disease? Lancet 1980;2:712-5.
2. Delpre G, Avidor I, Steinherz R, Kadish U, Ben-Bassat M. Ultrastructural abnormalities in endoscopically and histologically normal and involved colon in ulcerative colitis. Am J Gastroenterol 1989;84:1038-46.
3. Podolsky DK, Isselbacher KJ. Glycoprotein composition of colonic mucosa: specific alterations in ulcerative colitis. Gastroenterology 1984;87:991-8.
4. Morita H, Kettlewell MG, Jewell DP, Kent PW. Glycosylation and sulphation of colonic mucus glycoproteins in patients with ulcerative colitis and in healthy subjects. Gut 1993;34:926-32.
5. Podolsky DK, Fournier DA. Emergence of antigenic glycoprotein structures in ulcerative colitis detected through monoclonal antibodies. Gastroenterology 1988;95:371-8.
6. Podolsky DK, Fournier DA. Alterations in mucosal content of colonie glycoconjugates in inflammatory bowel disease defined by monoclonal antibodies. Gastroenterology 1988; 95:379-81.
7. Gibson PR, van de Pol E, Barratt PJ, Doe WF. Ulcerative colitis: a disease characterised by the abnormal colonic epithelial cell? Gut 1988;29:516-21.
8. Gibson P, Rosella O, Nov R, Young G. Colonic epithelium is diffusely abnormal in ulcerative colitis and colorectal cancer. Gut 1995;36:857-63.
9. Gibson P, Rosella O. Interleukin 8 secretion by colonic crypt cells in vitro: response to injury suppressed by butyrate and enhanced in inflammatory bowel disease. Gut 1995;37:536-43.
10. Kirchheimer JC, Binder BR. Function of receptor-bound urokinase. Semin Thromb Hemost 1991;17:246-50.
11. Pollanen J, Saksela O, Salonen EM, et al. Distinct localizations of urokinase-type plasminogen activator and its type I inhibitor under cultured human fibroblasts and sarcoma cells. J Cell Biol 1987;104:1085-96.
12. Takahashi K, Ikeo K, Gojorbori T, Tanifuji M. Local function of urokinase receptor at the adhesion contact sites of a metastatic tumour cell. Thromb Res 1990;10(suppl):55-61.
13. Schmitt M, Chucholowski N, Busch E, et al. Fluorescent probes as tools to assess the receptor for the urokinase-type plasminogen activator on tumor cells. Semin Thromb Hemost 1991;17:291-302.
14. Blasi F. Urokinase and urokinase receptor: a paracrine/ autocrine system regulating cell migration and invasiveness. Bioessays 1993;15:105-11.
15. Morimoto K, Mishima H, Nishida T, Otori T. Role of urokinase-type plasminogen activator (u-PA) in corneal epithelial migration. Thromb Haemost 1993;69:387-91.
16. Del Rosso M, Anachini W, Pederson N, et al. Urokinase-urokinase receptor interaction: non-mitogenic signal transduction in human epidermal cells. Biochem Biophys Res Commun 1993;190:347-52.
17. Busso N, Maur SK, Lazega D, Waxman S, Ossowski L. Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells. J Cell Biol 1994;126:259-70.
18. Lazarus GS, Jensen PJ. Plasminogen activators in epithelial biology. Semin Thromb Hemost 1991;17:210-6.
19. Gibson PR, van de Pol E, Doe WF. Cell associated urokinase activity and colonie epithelial cells in health and disease. Gut 1991;32:191-5.
20. Boyd D, Florent G, Kim P, Brattain M. Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines. Cancer Res 1988;48:3112-6.
21. Ganesh S, Sier CFM, Heerding MM, Griffioen G, Lamers CBHW, Verspaget HW. Urokinase receptor and colorectal cancer survival. Lancet 1994;344:401-2.
22. Gibson P, Rosella O, Rosella G, Young G. Secretion of urokinase and plasminogen activator inhibitor-1 by normal colonie epithelium in vitro. Gut 1994;35:969-75.
23. Gibson PR, Rosella O, Rosella G, Young GP. Butyrate is a potent inhibitor of urokinase secretion by normal colonic epithelium in vitro. Gastroenterology 1994;107:410-9.
24. Gibson PR, van de Pol E, Maxwell LE, Gabriel A, Doe WF. Isolation of colonie crypts that maintain structural and metabolic viability in vitro. Gastroenterology 1989;96:283-91.
25. Gibson PR, Moeller I, Kagelari O, Folino M, Young GP. Contrasting effects of butyrate on expression of phenotypic markers of differentiation in neoplastic and non-neoplastic colonie epithelial cells in vitro. J Gastroenterol Hepatol 1991;7:165-72.
26. Gibson PR, Rosella O, Young GP. Serum-free medium increases expression of markers of differentiation in human colonie crypt cells. Gut 1994;35:791-7.
27. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1976;72:248-54.
28. Janicke F, Schmitt M, Hafter R, et al. Urokinase-type plasminogen activator (u-PA) antigen is a predictor of early relapse in breast cancer. Fibrinolysis 1990;4:69-78.
29. Coleman PL, Green GDJ. A sensitive coupled assay for plasminogen activator using a thiol ester substrate for plasmin. Ann NY Acad Sci 1981;370:617-26.
30. Declerck PJ, Alessi M-C, Verstreken M, Kruithog EKO, Juhan-Vague I, Collen D. Measurement of plasminogen activator inhibitor (PAI-1) in biological fluids, with a murine monoclonal antibody based enzyme-linked immunoabsorbent assay. Blood 1988;71:220-5.
31. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
32. Roldan AL, Cubellis MV, Masucci MT, et al. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface plasmin dependent proteolysis. EMBO J 1990;9:467-74.
33. Feil W, Lacy ER, Wong Y-MM, et al. Rapid epithelial restitution of human and rabbit colonie mucosa. Gastroenterology 1989;97:685-701.
34. Elliott R, Stephens RW, Doe WF. Expression of urokinase-type plasminogen activator in the mucosal lesions of inflammatory bowel disease. J Gastroenterol Hepatol 1987;2: 517-23.
35. De Bruin PAF, Crama-Bohbouth G, Verspaget HW, et al. Plasminogen activators in the intestine of patients with inflammatory bowel disease. Thromb Haemost 1988;60:262-6.
36. Gibson PR, Albert V, Nov R, Rosella O, Young GP. The relation of enterocyte-associated urokinase activity to position on the crypt-villus axis in rats. J Gastroenterol Hepatol 1994;9:A108.
37. Allan A, Bristol JB, Williamson RCN. Crypt cell production rate in ulcerative proctocolitis: differential increments in remission and relapse. Gut 1985;26:999-1003.
38. Vernia P, Gnaedinger A, Hauck W, Breuer RI. Organic anions and the diarrhoea of inflammatory bowel disease. Dig Dis Sci 1988;33:1353-8.
39. Bleiberg H, Mainguet P, Galand P, Chreien J, Dupont-Mairesse N. Cell renewal in the human rectum. In vivo autoradiographic study on active ulcerative colitis. Gastroenterology 1970;58:851-5.
40. Eastwood GL, Trier JS. Epithelial cell renewal in cultured rectal biopsies in ulcerative colitis. Gastroenterology 1973; 64:383-90.
41. Serafini EP, Kirk AP, Chambers TJ. Rate and pattern of epithelial cell proliferation in ulcerative colitis. Gut 1981;22: 648-52.