Opioid peptide receptor studies. 9. Identification of a novel non-μ- non-δ-like opioid peptide binding site in rat brain

Peptides

Volumn 19, Issue 6, 1998, Pages 1079-1090

  Qing, N I ^a   Heng, X U ^a   Partilla, John S ^a   Rice, Kenner C ^b   Matecka, Dorota ^b   Calderon, Silvia N ^b   Porreca, Frank ^c   Lai, Josephine ^c   Schmidhammer, Helmut ^d   Krassnig, Roland ^d   Rothman, Richard B ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Acetalin; Antisense DNA; Delta receptors; Ligand binding; Opiate receptors

Indexed keywords

COMPLEMENTARY DNA; DELTA OPIATE RECEPTOR; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; METENKEPHALINAMIDE[2 ALANINE]; MU OPIATE RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR OCCUPANCY; TISSUE DISTRIBUTION;

ANALGESICS, OPIOID; ANIMALS; BINDING SITES; BRAIN; BRAIN CHEMISTRY; BUPRENORPHINE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALIN, LEUCINE-2-ALANINE; ENKEPHALINS; LIGANDS; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN BINDING; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU;

ANIMALIA;

EID: 0345676556     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(98)00046-1     Document Type: Article

References (56)

1. Ahmed, M. S.; Zhou, D. H.; Cavinato, A. G.; Maulik, D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 44:861-871; 1989.
2. Arden, J. R.; Segredo, V.; Wang, Z.; Lameh, J.; Sadee, W. Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells. J. Neurochem. 65:1636-1645; 1995.
3. Belcheva, M. M.; Barg, J.; McHale, R. J.; Dawn, S.; Ho, M. T.; Ignatova, E.; Coscia, C. J. Differential down- and up-regulation of rat brain opioid receptor types and subtypes by buprenorphine. Mol. Pharmacol. 44:173-179; 1993.
4. cx binding sites. NIDA. Res. Monogr. 141:238; 1994.
5. Cha, X. Y.; Xu, H.; Ni, Q.; Partilla, J. S.; Rice, K. C.; Matecka, D.; Calderon, S. N.; Porreca, F.; Lai, J.; Rothman, R. B. Opioid peptide receptor studies. 4. Antisense oligode-oxynucleotide to the delta opioid receptor delineates opioid receptor subtypes. Regul. Pept. 59:247-253; 1995.
6. Cha, X. Y.; Xu, H.; Rice, K. C.; Porreca, F.; Lai, J.; Ananthan, S.; Rothman, R. B. Opioid peptide receptor studies. 1. Identification of a novel δ opioid receptor binding site in rat brain membranes. Peptides. 16:191-198; 1995.
7. Chen, Y.; Mestek, A.; Liu, J.; Hurley, J. A.; Yu, L. Molecular cloning and functional expression of a μ-opioid receptor from rat brain. Mol. Pharmacol. 44:8-12; 1993.
8. Cho, T. M.; Hasegaua, J.; Ge, B. L.; Loh, H. H. Purification to homogeneity of a mu-type of opioid receptor from rat brain. Proc. Natl. Acad. Sci. USA. 83:4138-4142; 1986.
9. Comer, S. D.; Burke, T. F.; Lewis, J. W.; Woods, J. H. Clocinnamox: a novel, systemically-active, irreversible opioid antagonist. J. Pharmacol. Exp. Ther. 262:1051-1056; 1992.
10. Dooley, C. T.; Chung, N. N.; Wilkes, B. C.; Schiller, P. W.; Bidlack, J. M.; Pasternak, G. W.; Houghten, R. A. An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library. Science (Washington DC). 266: 2019-2022; 1994.
11. Evans, C. J.; Keith, D. E., Jr.; Morrison, H.; Magendzo, K.; Edwards, R. H. Cloning of a delta opioid receptor by functional expression. Science (Washington DC). 258:1952-1955; 1992.
12. Gioannini, T. L.; Howard, A. D.; Hiller, J. M.; Simon, E. J. Purification of an active opioid binding protein from bovine striatum. J. Biol. Chem. 260:15117-15121; 1985.
13. Jiang, Q.; Takemori, A. E.; Sultana, M.; Portoghese, P. S.; Bowen, W. D.; Mosberg, H. I.; Porreca, F. Differential antagonism of opioid delta antinociception by enkephalin and naltrindole 5′-isothiocyanate: evidence for delta receptor subtypes. J. Pharmacol. Exp. Ther. 257:1069-1075; 1991.
14. Kieffer, B. L.; Befort, K.; Gaveriaux-Ruff, C.; Hirth, C. G. The δ-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc. Natl. Acad. Sci. USA. 89:12048-12052; 1992.
15. Kim, C.-H.; Rothman, R. B.; Jacobson, A. E.; Mattson, M. V.; Bykov, V.; Streaty, R. A.; Klee, W. A.; George, C.; Long, J. B.; Rice, K. C. Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro. J. Med. Chem. 32:1392-1398; 1989.
16. Knott, G. D.; Reece, D. K. MLAB: a civilized curve fitting system. Proceedings of the Online 1972 International Conference 1:497-526; 1972.
17. Kosterlitz, H. W.; Paterson, S. J.; Robson, L. E. Characterization of the kappa-subtype of the opiate receptor in the guinea pig brain. Br. J. Pharmacol. 73:939-949; 1981.
18. 2-agonist antinociception. Neuroreport. 5:1049-1052; 1994.
19. Lord, J. A.; Waterfield, A.; Hughes, J.; Kosterlitz, H. W. Endogenous opioid peptides: multiple agonists and receptors. Nature (London). 267:495-499; 1977.
20. Mattia, A.; Farmer, S. C.; Takemori, A. E.; Sultana, M.; Portoghese, P. S.; Mosberg, H. I.; Bowen, W. D.; Porreca, F. Spinal opioid delta antinociception in the mouse: mediation by a 5′-NTII-sensitive delta receptor subtype. J. Pharmacol. Exp. Ther. 260:518-525; 1992.
21. Mattia, A.; Vanderah, T.; Mosberg, H. I.; Porreca, F. Lack of antinociceptive cross-tolerance between enkephalin and deltorphin II in mice: evidence for delta receptor subtypes. J. Pharmacol. Exp.Ther. 258:583-587; 1991.
22. McGonigle, P.; Neve, K. A.; Molinoff, P. B. A quantitative method of analyzing the interaction of slightly selective radioligands with multiple receptor subtypes. Mol. Pharmacol. 30:329-337; 1986.
23. Mosberg, H. I.; Hurst, R.; Hruby, V. J.; Gee, K.; Yamamura, H. I.; Galligan, J. J.; Burkes, T. F. Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors. Proc. Natl. Acad. Sci. USA. 80:5871-5874; 1983.
24. Munson, P. J.; Rodbard, D. LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107:220-239; 1980.
25. Ni, Q.; Xu, H.; Partilla, J. S.; de Costa, B. R.; Rice, K. C.; Borsodi, A.; Hosztafi, S.; Rothman, R. B. Dihydrocodeinonehydrazone, dihydrocodeinone-oxime, naloxone-3-OMe-oxime and clocinnamox fail to irreversibly inhibit opioid kappa receptor binding. Neurochem. Res. 19:1159-1163; 1994.
26. 2a binding sites. Peptides. 14:1279-1294; 1993.
27. Paschen, W.; Djuricic, B. Extent of RNA editing of glutamate receptor subunit GluR5 in different brain regions of the rat. Cell. Mol. Neurobiol. 14:259-270; 1994.
28. 3H]phencyclidine (PCP) receptor binding by an enatiomeric pair of PCP analogs. Eur. J. Pharmacol. 74:107-108; 1981.
29. Robson, L. E.; Paterson, S. J.; Kosterlitz, H. W. Opiate receptors. Handbook of Psychopharmacology, Vol. 17. New York: Plenum Press; 1983:13-80.
30. Rodbard, D.; Lenox, R. H.; Wray, H. L.; Ramseth, D. Statistical characterization of the random errors in the radioimmunoassay dose-response variable. Clin. Chem. 22:350-358; 1976.
31. Rothman, R. B. Binding surface analysis: an intuitive yet quantitative method for the design and analysis of ligand binding studies. Alcohol. Drug. Res. 6:309-325; 1986.
32. Rothman, R. B. Evidence for heterogeneity of kappa-opioid binding sites: a review of data obtained using brain membranes depleted of mu and delta binding sites with irreversible agents. Analgesia. 1:27-49; 1994.
33. Rothman, R. B.; Bowen, W. D.; Bykov, V.; Schumacher, U. K.; Pert, C. B.; Jacobson, A. E.; Burke, T. R., Jr.; Rice, K. C. Preparation of rat brain membranes greatly enriched with either type-I-delta or type-II-delta opiate binding sites using site directed alkylating agents. Neuropeptides. 4:201-215; 1984.
34. 5-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity delta-binding site. Mol. Pharmacol. 27:399-409; 1985.
35. Rothman, R. B.; Bykov, V.; de Costa, B. R.; Jacobson, A. E.; Rice, K. C.; Brady, L. S. Interaction of endogenous opioid peptides and other drugs with four kappa opioid binding sites in guinea pig brain. Peptides. 11:311-331; 1990.
36. 3H]cycloFOXY binding in rat brain: further evidence that beta-FNA alkylates the opioid receptor complex. Synapse. 8:86-99; 1991.
37. Rothman, R. B., Holaday, J. W.; and Porreca, F. Allosteric Coupling Among Opioid Receptors: Evidence for an Opioid Receptor Complex. In: Herz, A.; ed. Handbook of experimental pharmacology, Volume 104, "Opioids." Berlin: Springer-Verlag; 1992:217-237.
38. Rothman, R. B.; Long, J. B.; Bykov, V.; Jacobson, A. E.; Rice, K. C.; Holaday, J. W. Beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence. J. Pharmacol. Exp. Ther. 247:405-416; 1988.
39. cx opioid peptide binding site. Peptides. 13:1137-1143; 1992.
40. cx binding site. Peptides. 12:359-364; 1991.
41. Rothman, R. B.; Xu, H.; Wang, J. B.; Partilla, J. S.; Kayakiri, H.; Rice, K. C.; Uhl, G. R. Ligand-selectivity of cloned human and rat opioid mu receptors. Synapse. 21:60-64; 1995.
42. max in ligand binding experiments. II. Simultaneous analysis of homologous and heterologous competition curves and analysis blocking and of "multiligand" dose-response surfaces. Anal. Biochem. 184:172-183; 1990.
43. Schmidhammer, H.; Burkard, W. P.; Eggstein-Aeppli, L.; Smith, C. F. Synthesis and biologic evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist. J. Med. Chem. 32:418-421; 1989.
44. Schmidhammer, H.; Jennewein, H. K.; Krassnig, R.; Traynor, J. R.; Patel, D.; Bell, K.; Mattersberger, K.; Jachs-Ewinger, C.; Jura, P.; Fraser, G. L.; Kalinin, V. N. Synthesis and biologic evaluation of 14-alkoxymorphinans. 11. 3-hydroxycyprodime and analogs: opioid antagonist profile in comparison to cyprodime. J. Med. Chem. 38:3071-3077; 1995.
45. Schmidhammer, H.; Smith, C. F.; Erlach, D.; Koch, M.; Krassnig, R.; Schwetz, W.; Wechner, C. Synthesis and biologic evaluation of 14-alkoxymorphinans. 3. Extensive study on cyprodime-related compounds. J. Med. Chem. 33:1200-1206; 1990.
46. Simon, E. J.; Gioannini, T. L. Opioid receptor multiplicity: isolation, purification, and chemical characterization of binding sites. In: Herz, A.; Akil, H.; Simon, E.J.; eds. Opioids I. Berlin: Springer-Verlag; 1993:3-26.
47. Simon, J.; Benyhe, S.; Hepp, J.; Khan, A.; Borsodi, A.; Szücs, M.; Medzihradszky, K.; Wollemann, M. Purification of a kappa-opioid receptor subtype from frog brain. Neuropeptides. 10:19-28; 1987.
48. Simonds, W. F.; Burke, T. R., Jr.; Rice, K. C.; Jacobson, A. E.; Klee, W. A. Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells. Proc. Natl. Acad. Sci. USA. 82:4974-4978; 1985.
49. Vanderah, T. W.; Wild, K. D.; Takemori, A. E.; Sultana, M.; Portoghese, P. S.; Bowen, W. D.; Mosberg, H. I.; Porreca, F. Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse. J. Pharmacol. Exp. Ther. 262:190-197; 1992.
50. Wahlestedt, C. Antisense oligonucleotide strategies in neuropharamcology. Trends Pharmacol. Sci. 15:42-46; 1994.
51. Wang, J.-B.; Imai, Y.; Eppler, C. M.; Gregor, P.; Spivak, C. E.; Uhl, G. R. μ opiate receptor: cDNA cloning and expression. Proc. Natl. Acad. Sci. USA. 90:10230-10234; 1993.
52. NCX binding sites is similar to the cloned mouse opioid δ receptor: further evidence for heterogeneity of δ opioid receptors. Peptides. 19:343-350, 1998.
53. Xu, H.; Ni, Q.; Jacobson, A. E.; Rice, K. C.; Rothman, R. B. Preliminary ligand binding data for subtypes of the delta opioid receptor in rat brain membranes. Life. Sci. 49:PL141-PL146; 1991.
54. ncx binding sites in rat brain: further evidence for heterogenity. Peptides. 13:1207-1213; 1992.
55. ncx binding sites in mouse brain: further evidence for δ receptor heterogeneity. Peptides. 14: 893-907; 1993.
56. Yasuda, K.; Raynor, K.; Kong, H.; Breder, C. D.; Takeda, J.; Reisine, T.; Bell, G. I. Cloning and functional comparison of κ and δ opioid receptors from mouse brain. Proc. Natl. Acad. Sci. USA. 90:6736-6740; 1993.