Novel bicyclic phosphordiamidate HIV protease inhibitors

Heterocycles

Volumn 43, Issue 11, 1996, Pages 2367-2376

  Smallheer, Joanne M ^a   Seitz, Steven P ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0345662649     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-96-7524     Document Type: Article

References (14)

1. Several recent publications have reported promising human clinical data for HIV protease inhibitors as effective therapeutic agents for HIV infection, i.e., Chemical and Engineering News, February 6, 1995, 7; F. Stewart, P. E. O. Williams, J. F. Delfraissy and D. Sereni, Clinical Pharmacol. and Therapeutics, 1994, 55, 145; K. E. Squires, M. S. Saag, H. Teppler, R. Pomerantz, S. Waldman, T. Bjomsson, E. Woolf, K. Yeh, E. Emini, and P. Deutsch, Clinical Res., 1994, 42, 280A ; Bassett and Schoenfeld Report on ACTG 229: Antiviral Trial of Combination Therapy presented at the Tenth Intl. Conf. on AIDS 8/94 in Yokohama, Japan; Pharma Japan, 1994, 1415, 16; X. Wei, S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, B. H. Hahn, M. S. Saag and G. M. Shaw, Nature, 1995, 373, 117; D. D. Ho, A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard and M. Markowitz, Nature, 1995, 373, 123; K. T. Chong, Exp. Opin. invest. Drugs, 1996, 25, 115.
2. Several recent publications have reported promising human clinical data for HIV protease inhibitors as effective therapeutic agents for HIV infection, i.e., Chemical and Engineering News, February 6, 1995, 7; F. Stewart, P. E. O. Williams, J. F. Delfraissy and D. Sereni, Clinical Pharmacol. and Therapeutics, 1994, 55, 145; K. E. Squires, M. S. Saag, H. Teppler, R. Pomerantz, S. Waldman, T. Bjomsson, E. Woolf, K. Yeh, E. Emini, and P. Deutsch, Clinical Res., 1994, 42, 280A ; Bassett and Schoenfeld Report on ACTG 229: Antiviral Trial of Combination Therapy presented at the Tenth Intl. Conf. on AIDS 8/94 in Yokohama, Japan; Pharma Japan, 1994, 1415, 16; X. Wei, S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, B. H. Hahn, M. S. Saag and G. M. Shaw, Nature, 1995, 373, 117; D. D. Ho, A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard and M. Markowitz, Nature, 1995, 373, 123; K. T. Chong, Exp. Opin. invest. Drugs, 1996, 25, 115.
3. Several recent publications have reported promising human clinical data for HIV protease inhibitors as effective therapeutic agents for HIV infection, i.e., Chemical and Engineering News, February 6, 1995, 7; F. Stewart, P. E. O. Williams, J. F. Delfraissy and D. Sereni, Clinical Pharmacol. and Therapeutics, 1994, 55, 145; K. E. Squires, M. S. Saag, H. Teppler, R. Pomerantz, S. Waldman, T. Bjomsson, E. Woolf, K. Yeh, E. Emini, and P. Deutsch, Clinical Res., 1994, 42, 280A ; Bassett and Schoenfeld Report on ACTG 229: Antiviral Trial of Combination Therapy presented at the Tenth Intl. Conf. on AIDS 8/94 in Yokohama, Japan; Pharma Japan, 1994, 1415, 16; X. Wei, S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, B. H. Hahn, M. S. Saag and G. M. Shaw, Nature, 1995, 373, 117; D. D. Ho, A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard and M. Markowitz, Nature, 1995, 373, 123; K. T. Chong, Exp. Opin. invest. Drugs, 1996, 25, 115.
4. Several recent publications have reported promising human clinical data for HIV protease inhibitors as effective therapeutic agents for HIV infection, i.e., Chemical and Engineering News, February 6, 1995, 7; F. Stewart, P. E. O. Williams, J. F. Delfraissy and D. Sereni, Clinical Pharmacol. and Therapeutics, 1994, 55, 145; K. E. Squires, M. S. Saag, H. Teppler, R. Pomerantz, S. Waldman, T. Bjomsson, E. Woolf, K. Yeh, E. Emini, and P. Deutsch, Clinical Res., 1994, 42, 280A ; Bassett and Schoenfeld Report on ACTG 229: Antiviral Trial of Combination Therapy presented at the Tenth Intl. Conf. on AIDS 8/94 in Yokohama, Japan; Pharma Japan, 1994, 1415, 16; X. Wei, S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, B. H. Hahn, M. S. Saag and G. M. Shaw, Nature, 1995, 373, 117; D. D. Ho, A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard and M. Markowitz, Nature, 1995, 373, 123; K. T. Chong, Exp. Opin. invest. Drugs, 1996, 25, 115.
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6. Several recent publications have reported promising human clinical data for HIV protease inhibitors as effective therapeutic agents for HIV infection, i.e., Chemical and Engineering News, February 6, 1995, 7; F. Stewart, P. E. O. Williams, J. F. Delfraissy and D. Sereni, Clinical Pharmacol. and Therapeutics, 1994, 55, 145; K. E. Squires, M. S. Saag, H. Teppler, R. Pomerantz, S. Waldman, T. Bjomsson, E. Woolf, K. Yeh, E. Emini, and P. Deutsch, Clinical Res., 1994, 42, 280A ; Bassett and Schoenfeld Report on ACTG 229: Antiviral Trial of Combination Therapy presented at the Tenth Intl. Conf. on AIDS 8/94 in Yokohama, Japan; Pharma Japan, 1994, 1415, 16; X. Wei, S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, B. H. Hahn, M. S. Saag and G. M. Shaw, Nature, 1995, 373, 117; D. D. Ho, A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard and M. Markowitz, Nature, 1995, 373, 123; K. T. Chong, Exp. Opin. invest. Drugs, 1996, 25, 115.
7. Several recent publications have reported promising human clinical data for HIV protease inhibitors as effective therapeutic agents for HIV infection, i.e., Chemical and Engineering News, February 6, 1995, 7; F. Stewart, P. E. O. Williams, J. F. Delfraissy and D. Sereni, Clinical Pharmacol. and Therapeutics, 1994, 55, 145; K. E. Squires, M. S. Saag, H. Teppler, R. Pomerantz, S. Waldman, T. Bjomsson, E. Woolf, K. Yeh, E. Emini, and P. Deutsch, Clinical Res., 1994, 42, 280A ; Bassett and Schoenfeld Report on ACTG 229: Antiviral Trial of Combination Therapy presented at the Tenth Intl. Conf. on AIDS 8/94 in Yokohama, Japan; Pharma Japan, 1994, 1415, 16; X. Wei, S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, B. H. Hahn, M. S. Saag and G. M. Shaw, Nature, 1995, 373, 117; D. D. Ho, A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard and M. Markowitz, Nature, 1995, 373, 123; K. T. Chong, Exp. Opin. invest. Drugs, 1996, 25, 115.
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14. Prepared by pinacol coupling of N-Cbz-D-phenylalanal by the method described by A. W. Konradi and S. F. Pederson, J. Org. Chem., 1992, 57, 28.