The role of Fas ligand in the development of insulitis in nonobese diabetic mice

Pancreas

Volumn 16, Issue 2, 1998, Pages 154-159

  Sainio Pollanen S ^a   Erkkila S ^a   Alanko, S ^a   Hanninen A ^b   Pollanen P ^a   Simell, O ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Apoptosis; Autoimmunity; CD95 ligand; Fas ligand

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; DNA; DNA FRAGMENT; FAS LIGAND; THYMIDINE; TRITIUM;

ADOLESCENT; AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEGENERATION; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; INSULITIS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PANCREAS ISLET; PHAGOCYTOSIS; PRIORITY JOURNAL;

EID: 0345647067     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199803000-00008     Document Type: Article

References (22)

1. Miyazaki A, Hanafusa T, Yamada K, et al. Predominance of T lymphocytes in pancreatic islets and spleen of prediabetic non-obese diabetic (NOD) mice: a longitudinal study. Clin Exp Immunol 1985;60:622-30.
2. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 1995;270:1189-92.
3. Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC. A role for CD95 ligand in preventing graft rejection. Nature 1995; 377:630-2.
4. Trauth BC, Klas C, Peter AMJ, et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 1989;245:301-5.
5. Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993;75:1169-78.
6. Tanaka M, Suda T, Takahashi T, Nagata S. Expression of the functional soluble form of human fas ligand in activated lymphocytes. EMBO J 1995;14:1129-35.
7. Oehm A, Behrmann I, Falk W, et al. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen. J Biol Chem 1992;267:10709-15.
8. Gulbins E, Bissonnette R, Mahboudi A, et al. Fas-induced apoptosis is mediated via a ceramide-initiated RAS signalling pathway. Immunity 1995;2:341-51.
9. Boise LH, Minn AJ, Noel PJ, et al. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity 1995;3:87-98.
10. Sainio-Pöllänen S, Rulli M, Pöllänen P, Simell O. Appearance of cells expressing B7-1 and B7-2 costimulatory antigens in the pancreas of non-obese diabetic mice. Pancreas 1996;13:388-94.
11. Cerwenka A, Kovar H, Majdic O, Holter W. Fas- and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-β1. J Immunol 1996;156:459-64.
12. Kovacs B, Tsokos GC. Cross-linking of the Fas/APO-1 antigen suppresses the CD3-mediated signal transduction events in human T lymphocytes. J Immunol 1995;155:5543-9.
13. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4.
14. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
15. Billig H, Furuta I, Hsueh JW. Gonadotropin-releasing hormone directly induces apoptotic cell death in the rat ovary: biochemical and in situ detection of deoxyribonucleic acid fragmentation in granulosa cells. Endocrinology 1994;134:245-51.
16. Böyum A. Isolation of mononuclear cells and granulocytes from human peripheral blood. Scand J Clin Lab Invest 1968;21(Suppl 97):77-89.
17. Garschon HJ, Luan JJ, Eloy L, Bedossa P, Bach JF. Genetic analysis of immune dysfunction in non-obese diabetic (NOD) mice: mapping of a susceptibility locus close to the Bcl-2 gene correlates with increased resistance of NOD T cells to apoptosis induction. Eur J Immunol 1994;24:380-4.
18. Giordano C, De Maria R, Stassi G, et al. Defective expression of the apoptosis-inducing CD95 (Fas/Apo-1) molecule on T and B cells in IDDM. Diabetologia 1995;38:1449-54.
19. Hahn S, Gehri R, Erb P. Mechanism and biological significance of CD4-mediated cytotoxicity. Immunol Rev 1995;146:57-79.
20. Drappa J, Brot N, Elkon KB. The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr. Proc Natl Acad Sci 1993;90:10340-4.
21. Hancock WW, Polanski M, Zhang J, Blogg N, Weiner HL. Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E. Am J Pathol 1995;147:1193-9.
22. Bergerot I, Fabien N, Maguer V, Thivolet C. Oral administration of human insulin to NOD mice generates CD4+ T cells that suppress adoptive transfer of diabetes. J Autoimmun 1994;7:655-63.