A transcriptional repressor of the tissue factor gene in endothelial cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 7, 1999, Pages 1804-1811

  Holzmüller, Harry ^c   Moll, Thomas ^a   Hofer Warbinek, Renate ^c   Mechtcheriakova, Diana ^c   Binder, Bernd R ^c   Hofer, Erhard ^b  

^a Cardiogene AG   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

^c NONE

Author keywords

Endothelium; Tissue factor; Transcriptional repressor

Indexed keywords

ANIMAL CELL; ARTICLE; BLOOD CLOTTING; CATTLE; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; REPORTER GENE; REPRESSOR GENE; SWINE; TRANSCRIPTION REGULATION; VASCULAR ENDOTHELIUM;

EID: 0345643519     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.7.1804     Document Type: Article

References (33)

1. Edgington TS, Mackman N, Brand K, Ruf W. The structural biology of expression and function of tissue factor. Thromb Haemost. 1991;66: 67-79.
2. Ruf W, Edgington TS. Structural biology of tissue factor, the initiator of thrombogenesis in vivo. FASEB J. 1994;8:385-390.
3. Martin DM, Boys CW, Ruf W. Tissue factor: molecular recognition and cofactor function. FASEB J. 1995;9:852-859.
4. Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues: implications for disorders of hemostasis and thrombosis. Am J Pathol. 1989;134:1087-1097.
5. Wilcox JN, Smith KM, Schwartz SM, Gordon D. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci U S A. 1989;86:2839-2843.
6. Fleck RA, Rao LV, Rapaport SI, Varki N. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody. Thromb Res. 1990;59:421-437.
7. Morrissey JH, Drake TA. Procoagulant response of the endothelium and monocytes. In: Schlag G, Riedl H, eds. Pathophysiology of Shock, Sepsis and Organ Failure. Berlin, Germany: Springer-Verlag; 1993:564-574.
8. Kirchhofer D, Tschopp TB, Hadvary P, Baumgartner HR. Endothelial cells stimulated with tumor necrosis factor-alpha express varying amounts of tissue factor resulting in inhomogenous fibrin deposition in a native blood flow system: effects of thrombin inhibitors. J Clin Invest. 1994;93:2073-2083.
9. Levi M, ten Cate H, Bauer KA, van der Poll T, Edgington TS, Buller HR, van Deventer SJ, Hack CE, ten Cate J, Rosenberg RD. Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J Clin Invest. 1994;93:114-120.
10. Mackman N. Regulation of the tissue factor gene. Faseb J. 1995;9: 883-889.
11. Donovan-Peluso M, George LD, Hassett AC. Lipopolysaccharide induction of tissue factor expression in THP-1 monocytic cells: protein-DNA interactions with the promoter. J Biol Chem. 1994;269: 1361-1369.
12. Moll T, Czyz M, Holzmüller H, Hofer-Warbinek R, Wagner E, Winkler H, Bach FH, Hofer E. Regulation of the tissue factor promoter in endothelial cells: binding of NF kappa B-, AP-1-, and Sp1-like transcription factors. J Biol Chem. 1995;270:3849-3857.
13. Mackman N, Brand K, Edgington TS. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites. J Exp Med. 1991;174:1517-1526.
14. Parry GC, Mackman N. Transcriptional regulation of tissue factor expression in human endothelial cells. Arterioscler Thromb Vasc Biol. 1995;15:612-621.
15. Cui MZ, Parry GC, Oeth P, Larson H, Smith M, Huang RP, Adamson ED, Mackman N. Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1. J Biol Chem. 1996;271: 2731-2739.
16. Oeth PA, Parry GC, Kunsch C, Nantermet P, Rosen CA, Mackman N. Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a kappa B-like site. Mol Cell Biol. 1994;14:3772-3781.
17. Parry GC, Mackman N. A set of inducible genes expressed by activated human monocytic and endothelial cells contain kappa B-like sites that specifically bind c-Rel-p65 heterodimers. J Biol Chem. 1994;269: 20828-20825.
18. Warren JB. Large vessel endothelial isolation. In: Warren JB, ed. The Endothelium: An Introduction to Current Research. New York, NY: Wiley-Liss; 1990:263-272.
19. Wojta J, Hoover RL, Daniel TO. Vascular origin determines plasminogen activator expression in human endothelial cells. J Biol Chem. 1989;264: 2846-2852.
20. Wojta J, Gallicchio M, Zoellner H, Hufnagl P, Last K, Filonzi EL, Binder BR, Hamilton JA, McGrath K. Thrombin stimulates expression of tissue-type plasminogen activator and plasminogen activator inhibitor type 1 in cultured human vascular smooth muscle cells. Thromb Haemost. 1993;70:469-474.
21. Zhang JC, Fabry A, Paucz L, Wojta J, Binder BR. Human fibroblasts downregulate plasminogen activator inhibitor type-1 in cultured human macrovascular and microvascular endothelial cells. Blood. 1996;88: 3880-3886.
22. Cotten M, Wagner E, Bimstiel ML. Receptor-mediated transport of DNA into eukaryotic cells. Methods Enzymol. 1993;217:618-644.
23. de Martin R, Vanhove B, Cheng Q, Hofer E, Csizmadia V, Winkler H, Bach FH. Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B. EMBO J. 1993;12: 2773-2779.
24. de Wet J, Wood KV, DeLuca M, Helinski DR, Subramani S. Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol. 1987;7:725-737.
25. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989.
26. Mackman N, Morrissey JH, Fowler B, Edgington TS. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. Biochemistry. 1989;28: 1755-1762.
27. Chodosh LA, Carthew RW, Sharp PA. A single polypeptide possesses the binding and transcription activities of the adenovirus major late transcription factor. Mol Cell Biol. 1986;6:4723-4733.
28. Wasylyk B, Hahn SL, Giovane A. The Ets family of transcription factors. Eur J Biochem. 1993;211:7-18.
29. Jahroudi N, Lynch DC. Endothelial-cell-specific regulation of von Willebrand factor gene expression. Mol Cell Biol. 1994;14:999-1008.
30. Jahroudi N, Ardekani AM, Greenberger JS. An NF1-like protein functions as a represser of the von Willebrand factor promoter. J Biol Chem. 1996;271:21413-21421.
31. Mackman N, Fowler BJ, Edgington TS, Morrissey JH. Functional analysis of the human tissue factor promoter and induction by serum. Proc Natl Acad Sci U S A. 1990;87:2254-2258.
32. Ernst P, Smale ST. Combinatorial regulation of transcription I: general aspects of transcriptional control. Immunity. 1995;2:311-319.
33. Johnson AD. The price of repression. Cell. 1995;81:655-658.