Optical resolution of N-methylamphetamine via diastereoisomeric salt formation with 2R,3R-O,O'-di-p-toluoyltartaric acid

Chirality

Volumn 11, Issue 5-6, 1999, Pages 373-375

  Kozma, Dávid ^a   Madarász, Zoltán ^a   Kassai, Csaba ^a   Fogassy, Elemér ^a  

^a BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

Acidic salt; Efficiency of the resolution; Enantiomer separation; Neutral salt; Tartrate

Indexed keywords

METHAMPHETAMINE;

CHIRALITY; CONFERENCE PAPER; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIASTEREOISOMER; DRUG SOLUBILITY; ENANTIOMER; OPTICAL RESOLUTION; PRIORITY JOURNAL;

EID: 0345593713     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1999)11:5/6<373::AID-CHIR4>3.0.CO;2-9     Document Type: Conference Paper

References (8)

1. Kozma D, Madarász Z, Ács M, Fogassy E. Study of mechanism of an optical resolutions via Diastereoisomeric salt formation by Pope-Peachy method. Tetrahedron Asymmetry 1994;5:193-194.
2. Kozma D, Novák Cs, Pokol G, Fogassy E. Study of the mechanism of optical resolutions via diastereoisomeric salt formation. Part 5. Thermoanalytical investigation of the optical resolution of the N-methylamphetamine by tartaric acid. J Therm Anal 1996;47:727-735.
3. Kozma D, Madarász Z, Fogassy E. Solvent free optical resolution of N-methyl-amphetamine by distillation after partial diastereoisomeric salt formation. Tetrahedron. In press.
4. Jacques J, Collet A, Wilen SH. Enantiomers, racemates and resolutions. Malabar, FL: Krieger Publishing Company; 1994; p 307-317.
5. Kozma D, Pokol G, Ács M. Calculation of the efficiency of optical resolutions on the basis of the binary phase diagram for the diastereoisomeric salts. J Chem Soc Perkin Trans II 1992;435-439.
6. Fogassy E, Lopata A, Faigl F, Ács M, Darvas F, Toke L. A quantitative approach to optical resolution. Tetrahedron Lett 1980;21:647-650.
7. Ács M, Fogassy E, Faigl F. A convenient method for optical resolutions via diastereoisomeric salt formation. Tetrahedron 1985;5:2465-2469.
8. Fogassy E, Ács M, Faigl F, Simon K, Rohonczy J, Ecsery Z. Pseudosymmetry and chiral discrimination in optical resolution via diastereoisomeric salt formation. The crystal structure of (R)-and (S)-N-methylamphetamine bitartrates. (RMERTA and SMERTA). J Chem Soc Perkin Trans II 1986;1881-1886.