Rethinking the Toxic Methanol Level

Journal of Toxicology - Clinical Toxicology

Volumn 41, Issue 6, 2003, Pages 793-800

  Kostic, Mark A ^a   Dart, Richard C ^a,b  

^a ROCKY MOUNTAIN POISON AND DRUG CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Ingestion; Methanol; Toxicity

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL DEHYDROGENASE; ANTIDOTE; FOLIC ACID; METHANOL;

ACID BASE BALANCE; ACIDOSIS; ALCOHOL BLOOD LEVEL; DIALYSIS; HUMAN; INGESTION; MAXIMUM ALLOWABLE CONCENTRATION; METHANOL POISONING; PRACTICE GUIDELINE; REFERENCE VALUE; REVIEW;

ACIDOSIS; ADOLESCENT; ADULT; ANTIDOTES; BICARBONATES; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; METHANOL; MIDDLE AGED; PYRAZOLES; TREATMENT OUTCOME;

EID: 0345564964     PISSN: 07313810     EISSN: None     Source Type: Journal    
DOI: 10.1081/CLT-120025344     Document Type: Review

References (34)

1. Mengin D. Rec d'Opht 1879; 3rd ser, 1:663-667.
2. Bennett IL, Cary FH, Mitchell GL, Cooper MN. Acute methyl alcohol poisoning: a review based on experiences in an outbreak of 323 cases. Medicine 1953; 32:431-433.
3. Barceloux DG, Bond GR, Krenzelok EP, Cooper H, Vale JA. American Academy Of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol-Clin Toxicol 2002; 40(4):415-446.
4. Hantson P, Haufroid V, Mahieu P. Determination of formic acid tissue and fluid concentrations in three fatalities due to methanol poisoning. Am J Forensic Med Pathol 2000; 21(4):335-358.
5. Sejersted OM, Jacobsen D, Ovrebo S, Jansen H. Formate concentrations in plasma from patients poisoned with methanol. Act Med Scand 1983; 213(2):105-110.
6. McMartin KE, Ambre JJ, Telphly TR. Methanol poisoning in human subjects. Role of formic acid accumulation in the metabolic acidosis. Am J Med 1980; 68(3):414-418.
7. Shahangian S, Ash KO. Formic and lactic acidosis in a fatal case of methanol intoxication. Clin Chem 1986; 32(3):395-397.
8. Röe O. Act Med Scand 1943; 113:558.
9. Röe O. Methanol poisoning, it's clinical course, pathogenesis and treatment. Act Med Scand 1946; 182(suppl 9):9-135.
10. Sharma AN. Toxic alcohols. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Howland MA, Hoffman RS, Nelson LS, eds. Goldfrank's Toxicologic Emergencies. 7th ed. New York: McGraw-Hill, 2002:980-994.
11. Berk WA, Henderson WV. Alcohols. In: Tintinalli JE, Kelen GD, Stapczynski JS, eds. Emergency Medicine: A Comprehensive Study Guide. 5th ed. New York: McGraw-Hill, 2000:1103-1109.
12. Gonda A, Gault H, Churchill D, Hollomby D. Hemodialysis for methanol intoxication. Am J Med 1978; 64(5):749-758.
13. Kaye S. Handbook of Medical Toxicology. 2nd ed. Springfield, IL: Charles C Thomas, 1961:214.
14. Becker CE. Methanol poisoning. J Emerg Med 1983; 1:51-58.
15. Martin-Amat G, Tephly TR, McMartin KE, Makar AB, Hayreh MS, Hayreh SS, Baumbach G, Cancilla P. Methyl alcohol poisoning. II. Development of a model for ocular toxicity in methyl alcohol poisoning using the rhesus monkey. Arch Opthalmol 1977; 95:1847-1850.
16. Jacobsen D, McMartin K. Antidotes for methanol and ethylene glycol poisoning. J Toxicol-Clin Toxicol 1997; 35(2):127-143.
17. Keyvan-Larijarni H, Tannenberg AM. Methanol intoxication, comparison of peritoneal dialysis and hemodialysis treatment. Arch Intern Med 1974; 134:293-296.
18. Jacobsen D, Webb R, Collins T, McMartin KE. Methanol and formate kinetics in late diagnosed methanol intoxication. Med Toxicol 1988; 3:418-423.
19. Kratz AL. Normal reference laboratory values. N Engl J Med 1998; 339:1063-1072.
20. Barone MA. The Harriet Lane Handbook. 14th ed. St. Louis, MO: Mosby, 1991.
21. Bakerman SB, Strausbach P. Bakerman's ABC's of Interpretive Laboratory Data. 3rd ed. Myrtle Beach, SC: Interpretive Laboratory Data, Inc., 1994.
22. Hantson P, de Tourtchaninoff M, Simoens G, Mahieu P, Boschi A, Beguin C, Guerit JM. Evoked potentials investigation of visual dysfunction after methanol poisoning. Crit Care Med 1999; 27(12):2707-2715.
23. Brent J, McMartin K, Phillips S, Aaron C, Kulig K. Fomepizole for the treatment of methanol poisoning. N Eng J Med 2001; 344(6):424-429.
24. Kerns W, Tomaszewski C, McMartin K, Ford M, Brent J. Formate kinetics in methanol poisoning. J Toxicol-Clin Toxicol 2002; 40(2):137-143.
25. Palatnick W, Redman LW, Sitar DS, Tenenbein M. Methanol half-life during ethanol administration: implications for management of methanol poisoning. Ann Emerg Med 1995; 26(2):202-207.
26. Hantson P, Mahieu P. Pancreatic injury following acute methanol poisoning. J Toxicol-Clin Toxicol 2000; 38(3):297-303.
27. Mahieu P, Hassoun A, Lauwerys R. Predictors of methanol intoxication with unfavourable outcome. Hum Toxicol 1989; 8:135-137.
28. Pappas SC, Silverman M. Treatment of methanol poisoning with ethanol and hemodialysis. Can Med Assoc J 1982; 126:1391-1394.
29. Ekins BR, Rollins DE, Duffy DP, Gregory MC. Standardized treatment of severe methanol poisoning with ethanol and hemodialysis. West J Med 1985; 142(3):337-340.
30. Hantson P, Lambermont JY, Mahieu P. Methanol poisoning during late pregnancy. J Toxicol-Clin Toxicol 1997; 35(2):187-191.
31. Brown MJ, Shannon MW, Woolf A, Boyer EW. Childhood methanol ingestion treated with fomepizole and hemodialysis. Pediatrics 2001; 108(4):E77.
32. Brent J, Lucas M, Kulig K, Rumack B. Methanol poisoning in a 6-week-old infant. J Pediatr 1991; 118(4):644-666.
33. Grufferman S, Morris D, Alvarez J. Methanol poisoning complicated by myoglobinuric renal failure. Amer J Emerg Med 1985; 3(1):24-26.
34. Mowry JB, Judge BS, Bloch R, Rusyniak DE. Rapid methanol clearance with high-flux hemodialysis [abstract]. J Toxicol-Clin Toxicol 2002; 40(5):609-610.