Medications and Falls in the Elderly: A Review of the Evidence and Practical Considerations

P and T

Volumn 28, Issue 11, 2003, Pages 724-726+733

  Riefkohl, Elsaris Z ^a   Bieber, Heather L ^a   Burlingame, Mark B ^a   Lowenthal, David T ^b  

^a N Florida S Georgia Vet Hlt Sys   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; LORAZEPAM; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

AGED; ANAMNESIS; CLINICAL PRACTICE; DISEASE ASSOCIATION; DRUG USE; FALLING; HUMAN; META ANALYSIS; REVIEW; RISK FACTOR; SYNDROME DELINEATION;

EID: 0345564956     PISSN: 10521372     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Rubenstein LZ, Josephson KR. The epidemiology of falls and syncope. Clin Geriatr Med 2002;18:141-158.
2. Campbell AJ, Borrie MJ, Spears GF. Risk factors for falls in a community-based prospective study of people 70 years and older. J Gerontol 1989;44:M112-M117.
3. Cumming RG. Falls and fractures in the elderly. Drugs Aging 1998;12:43-53.
4. American Geriatrics Society, British Geriatrics Society, and American Academy of Orthopaedic Surgeons Panel on Falls Prevention. Guideline for the prevention of falls in older persons. J Am Geriatr Soc 2001;49:664-672.
5. Rubenstein LZ, Powers CM, MacLean CH. Quality indicators for the management and prevention of falls and mobility problems in vulnerable elders. Ann Intern Med 2001;135:686-693.
6. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: A systematic review and meta-analysis, Part I. Psychotropic drugs. J Am Geriatr Soc 1999;47:30-39.
7. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: A systematic review and meta-analysis, Part II. Cardiac and analgesic drugs. J Am Geriatr Soc 1999;47:40-50.
8. Ray WA, Thapa PB, Gideon P. Benzodiazepines and the risk of falls in nursing home residents. J Am Geriatr Soc 2000;48:682-685.
9. Mendelson WB. The use of sedative/hypnotic medication and its correlation with falling down in the hospital. Sleep 1996;19:698-701.
10. Passaro A, Volpato S, Romagnoni F, et al. Benzodiazepines with different half-lives and falling in a hospitalized population: The GIFA study. J Clin Epidemiol 2000;53:1222-1229.
11. Ensrud KE, Blackwell TL, Mangione CM, et al. Central nervous system: Active medications and risk for falls in older women. J Am Geriatri Soc 2002;50:1629-1637.
12. Pierfitte C, Macouillard G, Thicoipe M, et al. Benzodiazepines and hip fractures in elderly people: Case-control study. BMJ 2001;322:704-708.
13. Wang PS, Bohn RL, Glynn RJ, et al. Hazardous benzodiazepine regimens in the elderly: Effects of half-life, dosage, and duration on risk of hip fracture. Am J Psychiatry 2001;158:892-898.
14. Ruthazer R, Lipsitz LA. Antidepressants and falls among elderly people in long-term care. Am J Public Health 1993;83:746-749.
15. Thapa PB, Gideon P, Cost TW, et al. Antidepressants and the risk of falls among nursing home residents. N Engl J Med 1998;339:875-882.
16. Mukai S, Lipsitz LA. Orthostatic hypotension. Clin Geriatr Med 2002;18:253-268.
17. Heitterachi E, Lord SR, Meyerkort P, et al. Blood pressure changes on upright tilting predict falls in older people. Age Ageing 2002;31:181-186.
18. Liu BA, Topper AK, Reeves RA, et al. Falls among older people: Relationship to medication use and orthostatic hypotension. J Am Geriatr Soc 1995;43:1141-1145.
19. Curb JD, Applegate WB, Vogt TM, et al. Antihypertensive therapy and falls and fractures in the systolic hypertension in the elderly program. J Am Geriatr Soc 1993;41:SA15.
20. Tinetti ME, Baker DI, McAvay G, et al. A multifactorial intervention to reduce the risk of falling among elderly people living in the community. N Engl J Med 1994;331(13):821-827.
21. Ray WA, Taylor JA, Meador KG, et al. A randomized trial of a consultation service to reduce falls in nursing homes. JAMA 1997;278:557-562.
22. Campbell AJ, Robertson MC, Gardner MM, et al. Psychotropic medication withdrawal and a home-based exercise program to prevent falls: A randomized, controlled trial. J Am Geriatr Soc 1999;47:850-853.
23. Haumschild MJ, Karfonta TL, Haumschild MS, et al. Clinical and economic outcomes of a fall-focused pharmaceutical intervention program. Am J Health Syst Pharm 2003;60:1029-1032.
24. Alsop K, Mac Mahon M. Withdrawing cardiovascular medications at a syncope clinic. Postgrad Med J 2001;77:403-405.
25. Machuca SF, Jamison GT, Burlingame MB, et al. Medication assessment by a multidisciplinary consultation service in elderly, ambulatory veterans at risk for falls (Abstract). Pharmacotherapy 1999;19:514.
26. Tinetti ME. Preventing falls in elderly persons. N Engl J Med 2003;348:42-49.
27. Lindenbaum J, Rosenberg IH, Wilson PWF, et al. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994;60:2-11.
28. Dhesi JK, Moniz C, Close JCT, et al. A rationale for vitamin D prescribing in a falls clinic population. Age Ageing 2002;31:267-271.
29. Basaria S, Dobs AS. Hypogonadism and androgen replacement therapy in elderly men. Am J Med 2001;110:563-572.
30. Danese MD, Powe NR, Sawin CT. Screening for mild thyroid failure at the periodic health examination: A decision and cost-effectiveness analysis. JAMA 1996;276:285-292.