Cell growth- And P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells

Oncology Reports

Volumn 10, Issue 5, 2003, Pages 1301-1305

  Yu, Ling ^a   Ugai, Shin Ichi ^a,b   O Wang, Jiyang ^c   Namba, Masayoshi ^c   Kadomatsu, Kenji ^d   Muramatsu, Takashi ^d   Matsubara, Shuichiro ^e   Sakiyama, Shigeru ^a   Tagawa, Masatoshi ^a  

^a CHIBA CANCER CENTER   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c Niimi University   (Japan)

^d NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

HSV TK; Midkine; P53; Promoter; Suicide gene

Indexed keywords

CARRIER PROTEIN; CYTOKINE; LUCIFERASE; MIDKINE; THYMIDINE KINASE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL DEATH; CELL DIVISION; CYTOMEGALOVIRUS; DOSE RESPONSE; DOWN REGULATION; FIBROBLAST; GENE DELETION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HERPES SIMPLEX VIRUS; HUMAN; METABOLISM; MOUSE; MUTATION; NEOPLASM; NUDE MOUSE; PROMOTER REGION; TIME; TUMOR SUPPRESSOR GENE;

ANIMALS; CARRIER PROTEINS; CELL DEATH; CELL DIVISION; CYTOKINES; CYTOMEGALOVIRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FIBROBLASTS; GENE DELETION; GENES, P53; HUMANS; LUCIFERASES; MICE; MICE, INBRED BALB C; MICE, NUDE; MUTATION; NEOPLASMS; PROMOTER REGIONS (GENETICS); SIMPLEXVIRUS; THYMIDINE KINASE; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0345563841     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.10.5.1301     Document Type: Article

References (25)

1. Miller N and Whelan J: Progress in transcriptionally targeted and regulatable vectors for genetic therapy. Hum Genet Ther 8: 803-815, 1997. (Pubitemid 27231908)
2. Mawatari F, Tsuruta S, Ido A, Ueki T, Nakao K, Kato Y, Tamaoki T, Ishii N and Nakata K: Retrovirus-mediated gene therapy for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by human α-fetoprotein enhancer directly linked to its promoter. Cancer Gene Ther 5: 301-306, 1998. (Pubitemid 128640016)
3. Maeda T, O-Wang J, Matsubara H, Asano T, Ochiai T, Sakiyama S and Tagawa M: A minimum c-erbB-2 promoter-mediated expression of herpes simplex virus thymidine kinase gene confers selective cytotoxicity of human breast cancer cells to ganciclovir. Cancer Gene Ther 8: 890-896, 2001. (Pubitemid 33086536)
4. Miyauchi M, Shimada H, Kadomatsu K, Muramatsu T, Matsubara S, Ikematsu S, Takenaga K, Asano T, Ochiai T, Sakiyama S and Tagawa M: Frequent expression of midkine gene in esophageal cancer suggests a potential usage of its promoter for suicide gene therapy. Jpn J Cancer Res 90: 469-475, 1999. (Pubitemid 29213554)
5. Adachi Y, Reynolds PN, Yamamoto M, Grizzle WE, Overtunf K, Matsubara S, Muramatsu T and Curiel DT: Midkine promoter-based adenoviral vector gene delivery for pediatric solid tumors. Cancer Res 60: 4305-4310, 2000. (Pubitemid 32103599)
6. Miyauchi M, Yoshida Y, Tada Y, Narita M, Maeda T, Bahar R, Kadomatsu K, Muramatsu T, Matsubara S, Nakagawara A, Sakiyama S and Tagawa M: Expression of herpes simplex virus-thymidine kinase gene controlled by a promoter region of the midkine gene confers selective cytotoxicity to ganciclovir in human carcinoma cells. Int J Cancer 91: 723-727, 2001. (Pubitemid 32115271)
7. Wesseling JG, Yamamoto M, Adachi Y, Bosma PJ, van Wijland M, Blackwell JL, Li H, Reynolds PN, Dmitriev I, Vickers SM, Huibregtse K and Curiel DT: Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma. Cancer Gene Ther 8: 990-996, 2001. (Pubitemid 33140318)
8. Choudhuri R, Zhang HT, Donnini S, Ziche M and Bicknell R: An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis. Cancer Res 57: 1814-1819, 1997. (Pubitemid 27199678)
9. Qi M, Ikematsu S, Ichihara-Tanaka K, Sakuma S, Muramatsu T and Kadomatsu K: Midkine rescues Wilms' tumor cells from cisplatin-induced apoptosis: regulation of Bcl-2 expression by Midkine. J Biochem 127: 269-277, 2000. (Pubitemid 30136910)
10. Takei Y, Kadomatsu K, Matsuo S, Itoh H, Nakazawa K, Kubota S and Muramatsu T: Antisense oligodeoxynucleotide targeted to Midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells. Cancer Res 61: 8486-8491, 2001. (Pubitemid 33131129)
11. Tsutsui J, Kadomatsu K, Matsubara S, Nakagawara A, Hamanoue M, Takao S, Shimazu H, Ohi Y and Muramatsu T: A new family of heparin-binding growth/differentiation factors: increased midkine expression in Wilms' tumor and other human carcinomas. Cancer Res 53: 1281-1285, 1993. (Pubitemid 23097103)
12. Garver RI Jr, Chan CS and Milner PG: Reciprocal expression of pleiotrophin and midkine in normal versus malignant lung tissues Am J Respir Cell Mol Biol 9: 463-466, 1993. (Pubitemid 2007488)
13. Aridome K, Tsutsui J, Takao S, Kadomatsu K, Ozawa M, Aikou T and Muramatsu T: Increased midkine gene expression in human gastrointestinal cancers. Jpn J Cancer Res 86: 655-661, 1995.
14. Adachi Y, Reynolds PN, Yamamoto M, Wang M, Takayama K, Matsubara S, Muramatsu T and Curiel DT: A midkine promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging. Cancer Res 61: 7882-7888, 2001. (Pubitemid 33049379)
15. Fushimi K, Iijima M, Gao C, Kondo T, Tsuji T, Hashimoto T, Mihara K and Namba M: Transformation of normal human fibroblasts into immortalized cells with the mutant p53 gene and X-rays. Int J Cancer 70: 135-140, 1997. (Pubitemid 27059717)
16. Kino E, Fushimi K, Gao C, Shima T, Mihara K and Namba M: Immortalization of mutant p53-transfected human fibroblasts by treatment with either 4-nitroquinoline 1-oxide or X-rays. In Vitro Cell Dev Biol 33: 628-632, 1997. (Pubitemid 27446363)
17. Kadomatsu K, Tomomura M and Muramatsu T: cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem Biophys Res Commun 151: 1312-1318, 1988. (Pubitemid 18095263)
18. Uehara K, Matsubara S, Kadomatsu K, Tsutsui J and Muramatsu T: Genomic structure of human midkine (MK), a retinoic acid-responsive growth/ differentiation factor. J Biochem 111: 563-567, 1992.
19. Baker SJ, Markowitz S, Fearon ER, Willson JK and Vogelstein B: Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249: 912-915, 1990.
20. El-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW and Vogelstein B: Definition of a consensus binding site for p53. Nat Genet 1: 45-49, 1992.
21. Ding BC, Whetstine JR, Witt TL, Schuetz JD and Matherly LH: Repression of human reduced folate carrier gene expression by wild-type p53. J Biol Chem 276: 8713-8719, 2001.
22. Arizti P, Fang L, Park I, Yin Y, Solomon E, Ouchi T, Aaronson SA and Lee SW: Tumor suppressor p53 is required to modulate BRCA1 expression. Mol Cell Biol 20: 7450-7459, 2000.
23. D'Souza S, Xin H, Walter S and Choubey D: The gene encoding p202, an interferon-inducible negative regulator of the p53 tumor suppressor, is a target of p53-mediated transcriptional repression. J Biol Chem 276: 298-305, 2001. (Pubitemid 32050320)
24. Borellini F and Glazer RI: Induction of Spl-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1. J Biol Chem 268: 7923-7928, 1993. (Pubitemid 23120371)
25. Agoff SN, Hou J, Linzer DI and Wu B: Regulation of the human hsp70 promoter by p53. Science 259: 84-87, 1993. (Pubitemid 23036091)