DPI-3290 [(+)-3-((α-R)-α -((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl) -N-(3-fluorophenyl)-N-methylbenzamide]. I. A Mixed Opioid Agonist with Potent Antinociceptive Activity

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 3, 2003, Pages 1221-1226

  Gengo, Peter J ^a   Pettit, Hugh O ^a   O'Neill, Scott J ^a   Wei, Ke ^a   McNutt, Robert ^a   Bishop, Michael J ^a   Chang, Kwen Jen ^a  

^a Ardent Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 HYDROXYBENZYL] N (3 FLUOROPHENYL) N METHYLBENZAMINE; 4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 HYDROXYBENZYL] N,N DIETHYLBENZAMIDE; BENZAMIDE DERIVATIVE; DELTA OPIATE RECEPTOR; DPI 3290; DPI 5201; DPI 5336; DPI 5337; DPI 5402; DPI 5701; DPI 5702; DPI 673; FENTANYL; KAPPA OPIATE RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; OPIATE AGONIST; ORG 41793; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; BRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BINDING; DRUG MECHANISM; GUINEA PIG; IC 50; ILEUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; VAS DEFERENS;

ANALGESICS; ANIMALS; BENZAMIDES; BENZENEACETAMIDES; BINDING, COMPETITIVE; BLOOD GAS ANALYSIS; BRAIN CHEMISTRY; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; GUINEA PIGS; ILEUM; MALE; MUSCLE, SMOOTH; NARCOTIC ANTAGONISTS; NARCOTICS; PAIN MEASUREMENT; PIPERAZINES; PYRROLIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STEREOISOMERISM; VAS DEFERENS;

EID: 0345550537     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.054361     Document Type: Article

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