Metabolism of glycerol-1,2,3-trimethylsuccinate in rat hepatocytes

Molecular and Cellular Biochemistry

Volumn 198, Issue 1-2, 1999, Pages 135-139

  Ladriere L ^a   Grue Sorensen G ^b   Bjorkling F ^b   Malaisse, W J ^a  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

^b LEO PHARMA A S   (Denmark)

Author keywords

Glycerol 1,2,3 trimethylsuccinate; Hepatocytes; Nutrient metabolism

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; CARBON 14; CARBON DIOXIDE; ESTER; GLUCOSE; GLYCEROL; GLYCOGEN; METHYL GROUP; SUCCINIC ACID;

ANIMAL CELL; ARTICLE; CELL METABOLISM; FEMALE; HYDROLYSIS; LIVER METABOLISM; NONHUMAN; NUCLEOTIDE METABOLISM; RAT;

AMINO ACIDS; ANIMALS; CARBON DIOXIDE; CARBON RADIOISOTOPES; CHLORIDE CHANNELS; FEMALE; GLUCOSE; GLYCEROL; GLYCOGEN; HYDROGEN-ION CONCENTRATION; LIVER; RATS; RATS, WISTAR; SUCCINATES;

EID: 0345493206     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006949914417     Document Type: Article

References (23)

1. Rognstad R: Gluconeogenesis in rat hepatocytes from monomethyl succinate and other esters. Arch Biochem Biophys 230: 605-609, 1984
2. Malaisse WJ, Sener A: Metabolic effects and fate of succinate esters in pancreatic islets. Am J Physiol 264: E434-E440, 1993
3. Zhang T-M, Rasschaert J, Malaisse WJ: Metabolism of succinic acid methyl esters in myocytes. Clin Nutr 14: 166-170, 1995
4. Zhang T-M, Rasschaert J, Malaisse WJ: Metabolism of succinic acid methyl esters in neural cells. Biochem Mol Med 54: 112-116, 1995
5. Zhang T-M, Jijakli H, Malaisse WJ: Nutritional efficiency of succinic acid and glutamic acid dimethyl esters in colon carcinoma cells. Am J Physiol 270: G852-G859, 1996
6. Bakkali Nadi A, Schoonheydt J, Zhang T-M, Malaisse WJ: Inhibition of D-glucose metabolism by the methyl esters of succinic acid in rat adipocytes. Med Sci Res 24: 443-444, 1996
7. Ladrière L, Zhang T-M, Malaisse WJ: Effects of succinic acid dimethyl ester infusion on metabolic, hormonal, and enzymatic variables in starved rats. J Parent Ent Nutr 20: 251-256, 1996
8. Malaisse WJ, Bakkali Nadi A, Ladrière L, Zhang T-M: Protective effects of succinic acid dimethyl ester infusion in experimental endotoxemia. Nutrition 13: 330-341, 1997
9. Eizirik DL, Welsh N, Niemann A, Velloso LA, Malaisse WJ: Succinic acid monomethyl ester protects rat pancreatic islet secretory potential against interleukin-1β (IL- 1β) without affecting glutamate decarboxylase expression or nitric oxide production. FEBS Lett 337: 298-302, 1994
10. Akkan AG, Malaisse WJ: Protective effect of succinic acid monomethylester against streptozotocin-induced diabetes mellitus. Med Sci Res 21: 467, 1993
11. Malaisse WJ: The esters of carboxylic nutrients as insulinotropic tools in non-insulin-dependent diabetes mellitus. Gen Pharmac 26: 1133-1141, 1995
12. Björkling F, Malaisse-Lagae F, Malaisse WJ: Insulinotropic action of novel succinic acid esters. Pharmacol Res 33: 273-275, 1996
13. Ladrière L, Laghmich A, Malaisse-Lagae F, Dannacher H, Björkling F, Malaisse WJ: Comparison between the insulinotropic potential of ten new esters of succinic acid. Eur J Pharmacol 344: 87-93, 1998
14. Malaisse WJ, Grue-Sorensen G, Björkling F: Metabolism of glycerol-1,2,3-trimethylsuccinate in rat pancreatic islets. Biochem Biophys Res Commun 236: 26-28, 1997
15. Seglen PO: Preparation of isolated rat liver cells. Meth Cell Biol 13: 29-83, 1976
16. Liu GT, Zhang T-M, Wang BE, Wang YW: Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 43: 147-152, 1992
17. Malaisse WJ, Maggetto C, Leclercq-Meyer V, Sener A: Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats. J Clin Invest 91: 432-436, 1993
18. Malaisse WJ, Sener A: Hexose metabolism in pancreatic islets. Feedback control of D-glucose oxidation by functional events. Biochim Biophys Acta 971: 246-254, 1988
19. Giroix M-H, Sener A, Malaisse WJ: D-glucose transport and concentration in tumoral insulin-producing cells. Am J Physiol 251: C847-C851, 1986
20. Sener A, Malaisse-Lagae F, Malaisse WJ: Fructose metabolism via the pentose cycle in tumoral islet cells. Eur J Biochem 170: 447-450, 1987
21. Zhang T-M, Sener A, Malaisse WJ: Metabolic effects and fate of succinic acid methyl esters in rat hepatocytes. Arch Biochem Biophys 314: 186-192, 1994
22. Malaisse WJ, Ladrière L, Laghmich A, Louchami K, Jijakli H, Viñambres C, Villanueva-Peñacarrillo ML, Valverde I, Björkling F: Insulinotropic action of 1,2,3-tri(methylsuccinyl)glycerol ester. Biochem Mol Med 62: 76-84, 1997
23. Malaisse WJ, Rasschaert J, Villanueva-Peñacarrillo ML, Valverde I: Respiratory, ionic, and functional effects of succinate esters in pancreatic islets. Am J Physiol 264: E428-E433, 1993