A bioluminescence method for the mapping of local ATP concentrations within the arterial wall, with potential to assess the in vivo situation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 4, 1999, Pages 950-958

  Levin, Max ^a   Björnheden, Tom ^a   Evaldsson, Margareta ^a   Walenta, Stefan ^b   Wiklund, Olov ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Adenosine triphosphate; Atherosclerosis; Bioluminescence; Hypoxia; Metabolic imaging

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY WALL; ARTICLE; ATHEROGENESIS; BIOLUMINESCENCE; CONTROLLED STUDY; DIFFUSION; ENERGY METABOLISM; HYPOXEMIA; IMAGE ANALYSIS; MALE; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; SWINE;

EID: 0345491003     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.4.950     Document Type: Article

References (31)

1. Wolinsky H, Glagov S. Nature of species differences in the medial distribution of aortic vasa vasorum in mammals. Circ Res. 1967;20: 409-421.
2. Werber AH, Heistad DD. Diffusional support of arteries. Am J Physiol. 1985;248:H901-H906.
3. Robertson AL. Oxygen requirements of the human arterial intima in atherogenesis. Progr Biochem Pharmacol. 1968;4:305-316.
4. Björnheden T, Bondjers G. Oxygen consumption in aortic tissue from rabbits with diet-induced atherosclerosis. Arteriosclerosis. 1987;7: 238-247.
5. Knehr HE, Heinle H, Betz E. Enhanced oxygen uptake and lactate production of smooth muscle cell proliferates of rabbit carotid arteries. Pflügers Arch. 1980;387:73-77.
6. Hueper WC. General reviews. Arterioscler Arch Pathol. 1944;38: 162-181.
7. Boxen I. Mechanisms of atherogenesis: endothelial hypoxia proposed as the major initiator. Med Hypotheses. 1985;18:297-311.
8. Crawford DW, Blankenhorn DH. Arterial wall oxygenation, oxyradicals, and atherosclerosis. Atherosclerosis. 1991;89:97-108.
9. Simanonok JP. Non-ischemic hypoxia of the arterial wall is a primary cause of atherosclerosis. Med Hypotheses. 1996;46:155-161.
10. Crawford DW, Kramsch DM. The oxygen environment of the arterial media in early rabbit hypertension. Exp Mol Pathol. 1988;49:215-233.
11. Santilli SM, Fiegel V̇D, Knighton DR. Changes in the aortic wall oxygen tensions of hypertensive rabbits. Hypertension and aortic wall oxygen. Hypertension. 1992;19:33-39.
12. Heughan C, Niinikoski J, Hunt TK. Oxygen tensions in lesions of experimental atherosclerosis of rabbits. Atherosclerosis. 1973;17:361-367.
13. Santilli SM, Fiegel V̇D. Knighton DR. Alloxan diabetes alters the rabbit transarterial wall oxygen gradient. J Vasc Surg. 1993;18:227-233.
14. Santilli SM, Stevens RB, Anderson JG, Caldwell MD. The effect of aging on the transarterial wall oxygen gradient. Ann Vasc Surg. 1995;9:146-151.
15. Santilli SM, Stevens RB, Anderson JG, Payne WD, Caldwell MD. Transarterial wall oxygen gradients at the dog carotid bifurcation. Am J Physiol. 1995;268:H155-H161.
16. Zemplenyi T, Crawford DW, Cole MA. Adaptation to arterial wall hypoxia demonstrated in vivo with oxygen microcathodes. Atherosclerosis. 1989;76:173-179.
17. Björnheden T, Evaldsson M, Wiklund O. A method for the assessment of hypoxia in the arterial wall, with potential application in vivo. Arterioscler Thromb Vasc Biol. 1996;16:178-185.
18. Björnheden T, Levin M, Evaldsson M, Wiklund O. Evidence of hypoxic areas within the arterial wall in vivo. Arterioscler Thromb Vasc Biol. In press.
19. Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A. 1993;90:4304-4308.
20. Arnqvist HJ, Lundholm L. Influence of oxygen tension of the metabolism of vascular smooth muscle: demonstration of a Pasteur effect. Atherosclerosis. 1976;25:245-253.
21. Ragazzi E, Froldi G, Pandolfo L, Chinellato A, De-Biasi M, Prosdocimi M, Caparrotta L, Fassina G. Segmental impairment of endothelium-mediated relaxation in thoracic aortas from atherosclerotic rabbits. Comparison to cholesterol infiltration and energy metabolism. Artery. 1989;16:327-345.
22. Heinle H. Metabolite concentration gradients in the arterial wall of experimental atherosclerosis. Exp Mol Pathol. 1987;46:312-320.
23. Lowry OH, and Passonneau JV. A Flexible System of Enzymatic Analysis. New York, NY: Academic Press; 1972.
24. Sokoloff L. Relation between physiological function and energy metabolism in the central nervous system. J Neurochem. 1978;29:13-26.
25. Mueller-Klieser W, Walenta S. Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging. Histochem J. 1993;25:407-420.
26. Björnheden T, Bylock A, Hansson GK, Bondjers G. A system for long-term perfusion of rabbit aorta in vitro. Arteriosclerosis. 1983;3: 366-382.
27. Paschen W, Niebur I, and Hossmann KA. A bioluminescence method for the demonstration of regional glucose distribution in brain slices. J Neurochem. 1981;36:513-517.
28. Walenta S, Dotsch J, Mueller-Klieser W. ATP concentrations in multicellular tumor spheroids assessed by single photon imaging and quantitative bioluminescence. Eur J Cell Biol. 1990;52:389-393.
29. Mueller-Klieser W, Walenta S, Paschen W, Kallinowski F, Vaupel P. Metabolic imaging in microregions of tumors and normal tissues with bioluminescence and photon counting. J Natl Cancer Int. 1988;80: 842-848.
30. Hodgkiss RJ, Jones G, Long A, Patrick J, Smith KA, Stratford MRL, Wilson GD. Flow cytometric evaluation of hypoxic cells in solid experimental tumors using fluorescence immunodetection. Br J Cancer. 1991; 63:119-125.
31. Butler TM, Davies RE. High energy phosphates in smooth muscle. In: Bohr DF, Somlyo AP, Sparks HV, eds. Handbook of Physiology. Vol. 2. Baltimore, MD: Williams and Wilkins; 1980:237-252.