Pyridazines, 81.1 a novel 1,2-diazine containing tricyclic system: Synthesis of pyridazino[3,4-b][1,5]-benzodiazepin-5-ones as potential HIV-1 reverse transcriptase inhibitors

Heterocycles

Volumn 45, Issue 4, 1997, Pages 673-682

  Heinisch, Gottfried ^a   Matuszczak, Barbara ^a   Mereiter, Kurt ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0345475888     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-96-7678     Document Type: Article

References (14)

1. 1. For part 80 see ref. 5.
2. For representative examples see a) R.C. Allen, P.A. Reitano, and H. Urbach, J. Med. Chem., 1978, 21, 838;
3. b) E.A. Hallinan, T.J. Hagen, R.K. Husa, S. Tsymbalov, S.N. Rao, J.-P. vanHoeck, M.F. Rafferty, A. Stapelfeld, M.A. Savage, and M. Reichman, J. Med. Chem., 1993, 36, 3293;
4. J. Schmutz, Arzneim.-Forsch. (Drug Res.), 1975, 25, 712;
5. M. Froimowitz and S. Rämsby, J. Med. Chem., 1991, 34, 1707;
6. e) K. Nagarajan, J. David, and G.A. Bhat, Indian J. Chem., Sect. B, 1985, 24B(8), 840,
7. (Chem. Abstr., 1986, 105, 42760q);
8. f) J.M. Klunder, K.D. Hargrave, M.A. West, E. Cullen, K. Pal, M.L. Behnke, S.R. Kapadia, D.W. McNeil, J.C. Wu, G.C. Chow, and J. Adams, J. Med. Chem., 1992, 35, 1887;
9. g) J.-F.F. Liégeois, F.A. Rogister, J. Bruhwyler, J. Damas, T.P. Nguyen, M.-O. Inarejos, E.M.G. Chleide, M.G.A. Mercier, and J.E. Delarge, J. Med. Chem., 1994, 37, 519;
10. h) A. Chimirri, R. Gitto, S. Grasso, A.M. Monforte, G. Romeo, and M. Zappalà, Heterocycles, 1993, 36, 865 and literature cited therein;
11. V.I. Cohen, B. Jin, M.S. Gitler, R.A. de la Cruz, S.F. Boulay, V.K. Sood, B.R. Zeeberg, and R.C. Reba, Eur. J. Med. Chem., 1995, 30, 61;
12. j) H. Doods, M. Entzeroth, and N. Mayer, European J. Pharmacol., 1991, 192, 147;
13. k) S.T. Phillips, T. de Paulis, B.M. Baron, B.W. Siegel, P. Seeman, H.H.M. Van Tol, H.-c Guan, and H.E. Smith, J. Med. Chem., 1994, 37, 2686.
14. K.D. Hargrave, J.R. Proudfoot, K.G. Grozinger, E. Cullen, S.R. Kapadia, U.R. Patel, V.U. Fuchs, S.C. Mauldin, J. Vitous, M.L. Behnke, J.M. Klunder, K. Pal, J.W. Skiles, D.W. McNeil, J.M. Rose, G.C. Chow, M.T. Skoog, J.C. Wu, G. Schmidt, W.W. Engel, W.G. Eberlein, T.D. Saboe, S.J. Campbell, A.S. Rosenthal, and J. Adams, J. Med. Chem., 1991, 34, 2231.