Hyaluronan fragments induce plasminogen activator inhibitor-1 and inhibit urokinase activity in mouse alveolar macrophages. A potential mechanism for impaired fibrinolytic activity in acute lung injury

Chest

Volumn 116, Issue SUPPL., 1999, Pages

  Horton, M R ^b   Olman, M A ^b   Noble, Paul W ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HYALURONIC ACID; PLASMINOGEN ACTIVATOR INHIBITOR 1; UROKINASE;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FIBRINOLYSIS; LUNG ALVEOLUS MACROPHAGE; LUNG INJURY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION;

EID: 0345465662     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.116.suppl_1.17S     Document Type: Conference Paper

References (3)

1. Eitzman DT, McCoy RD, Zheng X, et al. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 1996; 97:232-237
2. McKee CM, Penno MB, Cowman M, et al. Hyaluronan fragments induce chemokine gene expression in alveolar macrophages: the role of HA size and CD44. J Clin Invest 1996; 98:2403-2413
3. McKee CM, Lowenstein C, Horton MR, et al. Hyaluronan fragments induce nitric oxide synthase in murine macrophages through an NF-κB-dependent mechanism. J Biol Chem 1997; 272:8013-8018