Venous ulcers: Improved healing by iontophoretic administration of calcitonin gene-related peptide and vasoactive intestinal polypeptide

Plastic and Reconstructive Surgery

Volumn 101, Issue 1, 1998, Pages 90-93

  Gherardini, Giulio ^a   Gürlek, Ali ^b   Evans, Gregory R D ^b   Milner, Stephen M ^b   Matarasso, Alan ^b   Wassler, Michael ^b   Jernbeck, Jan ^b   Lundeberg, Thomas ^b  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADULT; AGED; ARTICLE; CHRONIC VEIN INSUFFICIENCY; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HUMAN; IONTOPHORESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SKIN ULCER; TRANSDERMAL DRUG ADMINISTRATION; ULCER HEALING;

AGED; CALCITONIN GENE-RELATED PEPTIDE; FEMALE; HUMANS; IONTOPHORESIS; MALE; MIDDLE AGED; TREATMENT OUTCOME; VARICOSE ULCER; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0345451098     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-199801000-00015     Document Type: Article

References (32)

1. Costello, C. T., and Jeske, A. H. Iontophoresis: Applications in transdermal medication delivery. Phys. Ther. 75: 554, 1995.
2. Lundeberg, T., Eriksson, S. V., and Malm, M. Electrical nerve stimulation improves healing of diabetic ulcers. Ann. Plast. Surg. 29: 328, 1992.
3. Lundeberg, T., Kjartansson, J., and Samuelson, U. E. Effect of electric nerve stimulation on healing of ischemic skin flaps. Lancet 24: 712, 1988.
4. Kjartansson, J., Lundeberg, T., Samuelson, U. E., and Dalsgaard, C. -J. Transcutaneous electrical nerve stimulation (TENS) increases survival of ischemic musculocutaneous flaps. Acta Physiol. Scand. 134: 95, 1988.
5. Lundeberg, T. Peripheral effects of sensory nerve stimulation in inflammation and ischemia. Scand. J. Rehabil. Med. S29: 61, 1993.
6. Kjartansson, J., Lundeberg, T., Samuelson, U. E., Dalsgaard, C. -J., and Hedén, P. Calcitonin gene-related peptide (CGRP) and transcutaneous electrical nerve stimulation (TENS) increase cutaneous blood flow in a musculocutaneous flap in the rat. Acta Physiol. Scand. 134: 89, 1988.
7. Jernbeck, J., and Dalsgaard, C. -J. Calcitonin gene-related peptide (CGRP) treatment of flaps with compromised circulation in man. Plast. Reconstr. Surg. 91: 236, 1993.
8. Gherardini, G., Lundeberg, T., Matarasso, A., Michaels, B., Gazelius, B., Brodda-Jansen, G., and Samuelson, U. Calcitonin gene-related peptide increases microcirculation after mechanically induced ischemia in an experimental island flap. Ann. Plast. Surg. 35: 178, 1995.
9. Gherardini, G., Evans, G. R. D., Theodorsson, E., Gurlek, A., Milner, S. M., Palmer, B., and Lundeberg, T. Calcitonin gene-related peptide in experimental ischemia. Implication of an endogenous anti-ischemic effect. Ann. Plast. Surg. 36: 1, 1996.
10. Falanga, V., Bourguignon, G. H., and Bourguignon, L. Y. Electrical stimulation increases the expression of fibroblast receptors for transforming growth factor-β. J. Invest. Dermatol. 88: 488, 1987.
11. Stromberg, B. V. Effects of electrical currents on wound contraction. Ann. Plast. Surg. 21: 121, 1988.
12. Wolcott, L. E., Wheeler, P. C., Hardwicke, H. M., and Rowley, B. A. Accelerated healing of skin ulcers by electrotherapy. Preliminary clinical results. South. Med. J. 62: 795, 1969.
13. Carley, P., and Wainapel, S. Electrotherapy for acceleration of wound healing: Low intensity direct current. Arch. Phys. Med. Rehabil. 66: 443, 1985.
14. Alvarez, O. M., Mertz, P. M., Smerbeck, R. V., and Eaglstein, W. H. The healing of superficial skin wounds is stimulated by external electrical current. J. Invest. Dermatol. 81: 144, 1983.
15. Im, M. J., Lee, W. P. A., and Hoopes, J. E. Effect of electrical stimulation on survival of skin flaps in pigs. Phys. Ther. 70: 37, 1990.
16. Cruz, N. I., Bayron, F. E., and Suarez, A. J. Accelerated healing of full-thickness burns by the use of high voltage pulsed galvanic stimulation in the pig. Ann. Plast. Surg. 23: 49, 1988.
17. Cooper, M. S., and Schliwa, M. Electrical and ionic control of tissue cell locomotion in a DC electric field. J. Neurosci. Res. 13: 223, 1985.
18. Thomas, C. L. (Ed.). Taber's Cyclopedic Medical Dictionary, 13th Ed. Philadelphia: F. A. Davis, 1977.
19. Cross, S. E., and Roberts, M. S. Importance of dermal blood supply and epidermidis on the transdermal iontophoretic delivery of monovalent cations. J. Pharm. Sci. 85: 584, 1995.
20. Rosenfeld, M. G., Mermod, J. -J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W., and Evans, R. M. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304: 129, 1983.
21. Skofitsch, G., and Jacobowitz, D. M. Calcitonin gene-related peptide: Detailed immunohistochemical distribution in the central nervous system. Peptides 6: 721, 1985.
22. Goodman, E. C., and Iversen, L. L. Calcitonin gene-related peptide: Novel neuropeptide. Life Sci. 38: 2169, 1986.
23. Brain, S. D., Williams, T. J., Tippins, J. R., Morris, H. R., and MacIntyre, I. Calcitonin gene-related peptide is a potent vasodilator. Nature 313: 54, 1985.
24. Franco-Cereceda, A., Saria, A., and Lundberg, J. M. Differential release of calcitonin gene-related peptide and neuropeptide Y from the isolated heart by capsaicin, ischaemia, nicotine, bradykinin and ouabain. Acta Physiol. Scand. 135: 173, 1989.
25. Dalsgaard, C. -J., Hultg 134 rdh-Nilsson, A., Haegerstrand, A., and Nilsson, J. Neuropeptides as growth factors. Possible roles in human diseases. Regul. Pept. 25: 1, 1989.
26. Hedén, P., Jernbeck, J., Kjartansson, J., and Samuelson, U. E. Increased skin flap survival and arterial dilatation by calcitonin gene-related peptide. A study in the pig. Scand. J. Plast. Reconstr. Surg. Hand Surg. 23: 11, 1989.
27. Kjartansson, J., Dalsgaard, C. -J., and Jonsson, C. -E. Decreased survival of experimental critical flaps in rats after sensory denervation with capsaicin. Plast. Reconstr. Surg. 79: 218, 1987.
28. Haegerstrand, A., Dalsgaard, C. -J., Jonzon, B., Larsson, O., and Nilsson, J. Calcitonin gene-related peptide stimulates proliferation of human endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 87: 3299, 1990.
29. Raud, J., Lundeberg, T., Brodda-Jansen, G., Theodorsson, E., and Hedquist, P. Potent anti-inflammatory action of calcitonin gene-related peptide. Biochem. Biophys. Res. Commun. 180: 1429, 1991.
30. Linderoth, B., Gherardini, G., Ren, B., and Lundeberg, T. Spinal cord stimulation reduces ischemia in an animal model of vasospasm. Neurosurgery 37: 1, 1995.
31. Ottaway, C. A., and Greenberg, G. R. Interaction of VIP with mouse lymphocytes: Specific binding and the modulation of mitogen response. J. Immunol. 132: 417, 1984.
32. Fantini, F., Pincelli, C., Romualdi, P., Lesa, G., and Seidenari, S. Cutaneous vasoactive intestinal polypeptide levels in the elicitation phase of allergic contact dermatitis. In B. Shroot and H. Schaefer (Eds.), Immunological and Pharmacological Aspects of Atopic and Contact Eczema. Pharmacology and the Skin. Basel, Switzerland: Karger, 1991.