Potent bivalent thrombin inhibitors: Replacement of the scissile peptide bond at P1-P1' with arginyl ketomethylene isosteres

Journal of Medicinal Chemistry

Volumn 42, Issue 16, 1999, Pages 3109-3115

  Steinmetzer, Torsten ^a,c   Zhu, Bing Yan ^b,d   Konishi, Yasuo ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b Shire Canada   (Canada)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARGINYL KETOMETHYLENE; BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8; FIBRIN; FIBRINOGEN; HEPARIN; HIRUDIN; PROTEIN C; THIOGLYCOLIC ACID; THROMBIN; THROMBIN INHIBITOR; THROMBOMODULIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTICOAGULATION; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CORONARY ARTERY DILATATION; DRUG POTENCY; FEEDBACK SYSTEM; FIBRINOLYTIC THERAPY; HEMOSTASIS; POLYMERIZATION; PROTEIN DEGRADATION; SYNTHESIS; THROMBOEMBOLISM; THROMBOSIS;

ANIMALS; CATTLE; FIBRIN; HIRUDINS; HUMANS; PEPTIDES; PROTEIN BINDING; PROTEINS; SERINE PROTEINASE INHIBITORS; SPECTROMETRY, FLUORESCENCE; THROMBIN;

EID: 0345426277     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9807297     Document Type: Article

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