메뉴 건너뛰기




Volumn 10, Issue 8, 1999, Pages 915-921

Concurrent irinotecan and 5-fluorouracil plus levo-folinic acid given every other week in the first-line management of advanced colorectal carcinoma: A phase I study of the Southern Italy Cooperative Oncology Group

Author keywords

5 fluorouracil; Advanced colorectal carcinoma; Biweekly regimen; Combination chemotherapy; CPT 11; First line treatment; Irinotecan

Indexed keywords

FLUOROURACIL; FOLINIC ACID; IRINOTECAN;

EID: 0345425754     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008339010655     Document Type: Article
Times cited : (18)

References (29)
  • 1
    • 0018264312 scopus 로고
    • Chemotherapy of gastrointestinal cancer
    • Moertel CG. Chemotherapy of gastrointestinal cancer. N Engl J Med 1978; 299: 1049-52.
    • (1978) N Engl J Med , vol.299 , pp. 1049-1052
    • Moertel, C.G.1
  • 2
    • 0026721532 scopus 로고
    • Modulation of fluorouracil by leucovorin in terms of response rate
    • The Advanced Colorectal Cancer Meta-Analysis Project. Modulation of fluorouracil by leucovorin in terms of response rate. J Clin Oncol 1992; 10: 896-903.
    • (1992) J Clin Oncol , vol.10 , pp. 896-903
  • 3
    • 0024358188 scopus 로고
    • DNA Topoisomerase I-targeted chemotherapy of human colon cancer in xenografts
    • Giovannella BC, Stehlin JS, Wall ME et al. DNA Topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. Science 1989; 246: 1046-8.
    • (1989) Science , vol.246 , pp. 1046-1048
    • Giovannella, B.C.1    Stehlin, J.S.2    Wall, M.E.3
  • 4
    • 0028853410 scopus 로고
    • Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials
    • Chabot GG, Abigerges D, Catimel G et al. Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials. Ann Oncol 1995; 6: 141-51.
    • (1995) Ann Oncol , vol.6 , pp. 141-151
    • Chabot, G.G.1    Abigerges, D.2    Catimel, G.3
  • 5
    • 0010917253 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of irinotecan during a phase II clinical trial in colorectal cancer
    • Canal P, Gay C, Dezeuse A et al. Pharmacokinetics and pharmacodynamics of irinotecan during a phase II clinical trial in colorectal cancer. J Clin Oncol 1996; 14: 2688-96.
    • (1996) J Clin Oncol , vol.14 , pp. 2688-2696
    • Canal, P.1    Gay, C.2    Dezeuse, A.3
  • 6
    • 0029919195 scopus 로고    scopus 로고
    • CPT-11 in the treatment of colorectal cancer: Clinical efficacy and safety profile
    • Rougier P, Bugat R. CPT-11 in the treatment of colorectal cancer: Clinical efficacy and safety profile. Semin Oncol 1996; 23 (Suppl. 3): 34-41.
    • (1996) Semin Oncol , vol.23 , Issue.3 SUPPL. , pp. 34-41
    • Rougier, P.1    Bugat, R.2
  • 7
    • 0030826929 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors: Review and update
    • Rothenberg ML. Topoisomerase I inhibitors: Review and update. Ann Oncol 1997; 8: 837-55.
    • (1997) Ann Oncol , vol.8 , pp. 837-855
    • Rothenberg, M.L.1
  • 8
    • 0027194943 scopus 로고
    • Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer
    • Shimada Y, Yoshino M, Wakui A et al. Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. J Clin Oncol 1993; 11: 909-13.
    • (1993) J Clin Oncol , vol.11 , pp. 909-913
    • Shimada, Y.1    Yoshino, M.2    Wakui, A.3
  • 9
    • 0029966672 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer
    • Rothember M, Eckardt JR, Kuhn JG et al. Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. J Clin Oncol 1996; 14: 1128-35.
    • (1996) J Clin Oncol , vol.14 , pp. 1128-1135
    • Rothember, M.1    Eckardt, J.R.2    Kuhn, J.G.3
  • 10
    • 0029919598 scopus 로고    scopus 로고
    • Irinotecan is an active agent in untreated patients with metastatic colorectal cancer
    • Conti JA, Kemeny NE, Saltz LB et al. Irinotecan is an active agent in untreated patients with metastatic colorectal cancer. J Clin Oncol 1996; 14: 709-15.
    • (1996) J Clin Oncol , vol.14 , pp. 709-715
    • Conti, J.A.1    Kemeny, N.E.2    Saltz, L.B.3
  • 12
    • 0029084773 scopus 로고
    • CPT-11 (Irinotecan) in the treatment of colorectal cancer
    • Armand JP, Ducreux M, Mahjoubi M et al. CPT-11 (Irinotecan) in the treatment of colorectal cancer. Eur J Cancer 1995; 31A: 1283-7.
    • (1995) Eur J Cancer , vol.31 A , pp. 1283-1287
    • Armand, J.P.1    Ducreux, M.2    Mahjoubi, M.3
  • 13
    • 0032585197 scopus 로고
    • Randomized trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
    • Rougier P, Van Cutsem E, Bajetta E et al. Randomized trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet 1988; 352: 1407-12.
    • (1988) Lancet , vol.352 , pp. 1407-1412
    • Rougier, P.1    Van Cutsem, E.2    Bajetta, E.3
  • 14
    • 0032585232 scopus 로고    scopus 로고
    • Randomized trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer
    • Cunningham D, Pyrhonen S, James RD et al. Randomized trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 1998; 352: 1413-8.
    • (1998) Lancet , vol.352 , pp. 1413-1418
    • Cunningham, D.1    Pyrhonen, S.2    James, R.D.3
  • 15
    • 0000919664 scopus 로고    scopus 로고
    • A phase II multicenter trial of alternating cycles of irinotecan (CPT-11) and 5-FU/LV in patients with previously untreated metastatic colorectal cancer (CRC)
    • Rothenberg ML, Pazdur R, Rowinsky EK et al. A phase II multicenter trial of alternating cycles of irinotecan (CPT-11) and 5-FU/LV in patients with previously untreated metastatic colorectal cancer (CRC). Proc Thirty-Third Meet Am Soc Clin Oncol 1997; 944: 266a.
    • (1997) Proc Thirty-Third Meet Am Soc Clin Oncol , vol.944
    • Rothenberg, M.L.1    Pazdur, R.2    Rowinsky, E.K.3
  • 16
    • 7844220589 scopus 로고    scopus 로고
    • A phase II study of irinotecan alternated with five days bolus of 5-fluorouracil and leucovorin in first-line chemotherapy of metastatic colorectal cancer
    • Van Cutsem E, Pozzo C, Starkjammar H et al. A phase II study of irinotecan alternated with five days bolus of 5-fluorouracil and leucovorin in first-line chemotherapy of metastatic colorectal cancer. Ann Oncol 1998; 9: 1199-204.
    • (1998) Ann Oncol , vol.9 , pp. 1199-1204
    • Van Cutsem, E.1    Pozzo, C.2    Starkjammar, H.3
  • 17
    • 0008461578 scopus 로고    scopus 로고
    • Phase I clinical trial and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors
    • Saltz LB, Kanowitz J, Kemeny NE et al. Phase I clinical trial and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors. J Clin Oncol 1996; 14: 2959-67.
    • (1996) J Clin Oncol , vol.14 , pp. 2959-2967
    • Saltz, L.B.1    Kanowitz, J.2    Kemeny, N.E.3
  • 19
    • 0345060632 scopus 로고    scopus 로고
    • Phase I-II study of CPT-11 in combination with LV + 5-FU ('De Gramont' regimen) every two weeks for the treatment of colorectal cancer (CRC) after 5-FU failure
    • Rougier Ph, Ychou M, Seitz JF et al. Phase I-II study of CPT-11 in combination with LV + 5-FU ('De Gramont' regimen) every two weeks for the treatment of colorectal cancer (CRC) after 5-FU failure. Proc ECCO 9, Eur J Cancer 1997; 33 (Suppl 8): 756: S169.
    • (1997) Proc ECCO 9, Eur J Cancer , vol.33 , Issue.8 SUPPL. , pp. 756
    • Rougier, Ph.1    Ychou, M.2    Seitz, J.F.3
  • 20
    • 0032977698 scopus 로고    scopus 로고
    • Phase I study of a weekly schedule of irinotecan, high-dose leucovorin, and infusional fluorouracil as first-line chemotherapy in patients with advanced colorectal cancer
    • Vanhoefer U, Harstrick A, Köhne CH et al. Phase I study of a weekly schedule of irinotecan, high-dose leucovorin, and infusional fluorouracil as first-line chemotherapy in patients with advanced colorectal cancer. J Clin Oncol 1999; 17: 907-13.
    • (1999) J Clin Oncol , vol.17 , pp. 907-913
    • Vanhoefer, U.1    Harstrick, A.2    Köhne, C.H.3
  • 21
    • 0000271237 scopus 로고    scopus 로고
    • Irinotecan in combination with leucovorin and 5-fluorouracil 48 hours continuous infusion: A phase I study with pharmacokinetic, DNA damage and topoisomerase I/DNA complexes evaluation in chemotherapy-naïve metastatic colorectal cancer patients
    • Falcone A, Allegrini G, Masi G et al. Irinotecan in combination with leucovorin and 5-fluorouracil 48 hours continuous infusion: A phase I study with pharmacokinetic, DNA damage and topoisomerase I/DNA complexes evaluation in chemotherapy-naïve metastatic colorectal cancer patients. Proc Thirty-Fourth Meet Am Soc Clin Oncol 1998; 1117: 290a.
    • (1998) Proc Thirty-Fourth Meet Am Soc Clin Oncol , vol.1117
    • Falcone, A.1    Allegrini, G.2    Masi, G.3
  • 22
    • 25344446436 scopus 로고    scopus 로고
    • A phase I study of CPT-11 plus chronomodulated (chrono) 5-fluorouracil (5-FU) and L-folinic acid (FA) in advanced colorectal cancer (ACC) patients
    • Garufi C, Tampellini M, D'Attino RM et al. A phase I study of CPT-11 plus chronomodulated (chrono) 5-fluorouracil (5-FU) and L-folinic acid (FA) in advanced colorectal cancer (ACC) patients. Proceedings of the 23rd Congress ESMO. Ann Oncol 1998; 9 (Suppl 4): 178O, 37.
    • (1998) Proceedings of the 23rd Congress ESMO. Ann Oncol , vol.9 , Issue.4 SUPPL.
    • Garufi, C.1    Tampellini, M.2    D'Attino, R.M.3
  • 23
    • 0030249114 scopus 로고    scopus 로고
    • Double biochemical modulation of 5-fluorouracil by methotrexate and levo-folinic acid in the treatment of advanced digestive tract malignancies
    • Cornella P, Palmieri G, Lorusso V et al. Double biochemical modulation of 5-fluorouracil by methotrexate and levo-folinic acid in the treatment of advanced digestive tract malignancies. Eur J Cancer 1996; 32A: 1719-26.
    • (1996) Eur J Cancer , vol.32 A , pp. 1719-1726
    • Cornella, P.1    Palmieri, G.2    Lorusso, V.3
  • 25
    • 0028853410 scopus 로고
    • Population pharmacokinetics and pharmacodinamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials
    • Chabot GG, Abigerges D, Catimel G et al. Population pharmacokinetics and pharmacodinamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials. Ann Oncol 1995; 6: 141-51.
    • (1995) Ann Oncol , vol.6 , pp. 141-151
    • Chabot, G.G.1    Abigerges, D.2    Catimel, G.3
  • 26
    • 0028854897 scopus 로고
    • Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every three weeks in cancer patients
    • Abigerges D, Chabot GG, Armand J-P et al. Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every three weeks in cancer patients. J Clin Oncol 1995; 13: 210-21.
    • (1995) J Clin Oncol , vol.13 , pp. 210-221
    • Abigerges, D.1    Chabot, G.G.2    Armand, J.-P.3
  • 27
    • 0010917253 scopus 로고    scopus 로고
    • Pharmakokinetics and pharmakodinamics of irinotecan during a phase II clinical trial in colorectal cancer
    • Gay CC, Dezeuse A, Douillard JY et al. Pharmakokinetics and pharmakodinamics of irinotecan during a phase II clinical trial in colorectal cancer. J Clin Oncol 1996; 14: 2688-95.
    • (1996) J Clin Oncol , vol.14 , pp. 2688-2695
    • Gay, C.C.1    Dezeuse, A.2    Douillard, J.Y.3
  • 28
    • 25344459337 scopus 로고    scopus 로고
    • Schedule-dependent antitumor efficacy of irinotecan (CPT-11) and 5-fluorouracil (5-FU) in nude mice bearing colon tumor xenografts that are resistant to 5-FU
    • Vanhoefer U, Hapke G, Harstrick A et al. Schedule-dependent antitumor efficacy of irinotecan (CPT-11) and 5-fluorouracil (5-FU) in nude mice bearing colon tumor xenografts that are resistant to 5-FU. Proceedings of the 23rd ESMO Congress. Ann Oncol 1998; 9 (Suppl 4): 634P, 132.
    • (1998) Proceedings of the 23rd ESMO Congress. Ann Oncol , vol.9 , Issue.4 SUPPL.
    • Vanhoefer, U.1    Hapke, G.2    Harstrick, A.3
  • 29
    • 85102663207 scopus 로고    scopus 로고
    • 2) as first-line chemotherapy for metastatic colorectal cancer: Preliminary results of a multicentre phase II trial
    • 2) as first-line chemotherapy for metastatic colorectal cancer: Preliminary results of a multicentre phase II trial. Proceedings of the 23rd ESMO Congress. Ann Oncol 1998; 9 (Suppl 4): 181P, 38.
    • (1998) Proceedings of the 23rd ESMO Congress. Ann Oncol , vol.9 , Issue.4 SUPPL.
    • Ychou, M.1    Kramar, A.2    Raoul, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.