Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine

Carcinogenesis

Volumn 20, Issue 7, 1999, Pages 1323-1329

  Iki, Katsumichi ^b   Tsutsumi, Masahiro ^a   Kido, Akira ^a   Sakitani, Hiroyuki ^a   Takahama, Makoto ^a   Yoshimoto, Masatoshi ^a   Motoyama, Masaaki ^c   Tatsumi, Kunihiko ^c   Tsunoda, Tsukasa ^b   Konishi, Yoichi ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b KAWASAKI MEDICAL SCHOOL   (Japan)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BIS(2 OXOPROPYL)NITROSAMINE; COLLAGENASE; GELATINASE A; MEMBRANE ENZYME; MESSENGER RNA; OPB 3206; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GRAFT; CANCER PREVENTION; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE OVEREXPRESSION; HAMSTER; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; NONHUMAN; NORTHERN BLOTTING; ORAL DRUG ADMINISTRATION; PANCREAS ADENOCARCINOMA; PANCREAS DUCT; PRIORITY JOURNAL; PROTEIN EXPRESSION; ZYMOGRAPHY;

ADENOCARCINOMA; ANIMALS; BLOTTING, WESTERN; COLLAGENASES; CRICETINAE; ENZYME ACTIVATION; ENZYME PRECURSORS; FEMALE; GELATIN; GELATINASES; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; NITROSAMINES; PANCREATIC DUCTS; PANCREATIC NEOPLASMS; PROTEASE INHIBITORS; QUINOLONES; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 0345379633     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.7.1323     Document Type: Article

References (38)

1. Den Besten, P.K., Panzi, J.S. and Li, W. (1998) Purification and sequencing of a 21kDa and 25kDa bovine enamel metalloproteinase. Eur. J. Oral. Sci., 106, 345-349.
2. Llano, E., Pendas, A.M., Knauper, V., Sorsa, T., Salido, E., Murphy, G., Simmer, J.P., Bartlett, J.D. and Lopez-Otin, C. (1997) Identification and structual and functional characterization of human enamelysin (MMP-20). Biochemistry, 36, 15101-15108.
3. Zena, W. (1997) ECM and cell surface proteolysis: regulating cellular ecology. Cell, 91, 439-442.
4. Ohtani, H. (1998) Stromal reaction in cancer tissue: pathophysiologic significance of the expression of matrix-degrading enzymes in relation to matrix turnover and immune/inflammatory reactions. Pathol. Int., 48, 1-9.
5. Tokuraku, M., Satoji, Murakami, S., Okada, Y., Watanabe, Y. and Seiki, M. (1995) Activation of the precursor of gelatinase A/72kDa type collagenase/ MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasis. Int. J. Cancer, 64, 355-359.
6. Brown, P.D., Bloxide, R., Stuart, N.S.A., Gatter, C. and Carmichael, J. (1993) Association between expression of activated 72-kDa gelatinase and tumor spread in non-small-cell lung carcinoma. J. Natl Cancer Inst., 85, 574-578.
7. Nomura, H., Sato, H., Seiki, M., Mai, M. and Okada, Y. (1995) Expression of membrane-type matrix metalloproteinase in human gastric carcinomas. Cancer Res., 55, 3263-3266.
8. Ueno, H., Nakamura, H., Inoue, M., Imai, K., Noguchi, M., Sato, H., Seiki, M. and Okada, Y. (1997) Expression and tissue localization of membrane-types 1, 2 and 3 matrix metalloproteinases in human invasive breast carcinomas. Cancer Res., 57, 2055-2060.
9. Brown, P.D., Bloxidge, R.E., Anderson, E. and Howell, A. (1993) Expression of activated gelatinase in human invasive breast carcinoma. Clin. Exp. Metastasis, 11, 183-189.
10. Devies, B., Miles, D.W., Happerfield, L.C., Naylar, M.S., Bobrow, L., Rubens, R.D. and Balkwill, F.R. (1993) Activity of type collagenases in benign and malignant breast disease. Br. J. Cancer, 67, 1126-1131.
11. Simon, R.B., Jhon, P.N., Goldon, W.H.S. and Nicholas, R.L. (1997) Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in human pancreatic carcinoma. J. Pathol., 182, 347-355.
12. Takaoka, K., Ryo, H., Michihoko, W., Koji, F., Jeon, U.L., Ryuichiro, D., Shigeki, A. and Masayuki, I. (1997) Detection of matrix metalloproteinase activity in human pancreatic cancer. Jpn J. Surg., 27, 302-304.
13. Okada, Y., Morodomi, T., Enghild, J.J., Suzuki, K., Yasui, A., Nakanishi, I., Salvesen, G. and Nagase, H. (1990) Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts: purification and activation of the precursor and enzymic properties. Eur. J. Biochem., 194, 721-731.
14. Ward, R.V., Atkinson, S.J., Reynolds, J.J. and Murphy, G. (1994) Cell surface activation of progelatinase A in cell surface binding and activation of progelatinase A by primary fibroblasts. Biochem. J., 304, 263-269.
15. Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E. and Seiki, M. (1994) A matrix metalloproteinase expressed on the surface of invasive tumor cells. Nature, 370, 61-65.
16. Knapp, M.L. (1981) Partial characterization of an oncofetal antigen: its role in the differential diagnosis and therapy of patients with pancreatic cancer. Ann. Clin. Biochem., 18, 131-143.
17. Health and Welfare Statistics in Japan. (1993) Main causes of death in Japan. J. Health Welfare Stat., 40 (Suppl.), 52-60 (in Japanese).
18. Pour,P ., Kruger, F.W., Althoff, J., Cardesa, A. and Mohr, U. (1974) Cancer of the pancreas induced in the syrian golden hamster. Am. J. Pathol., 76, 349-358.
19. Pour, P.M., Salmasi, S.Z. and Runge, R.G. (1974) Selective induction of pancreatic ductular tumors by single dose of N-nitrosobis(2-oxopropyl)amine in syrian golden hamsters. Cancer Lett., 4, 317-323.
20. Pour, P.M., Runge, R.G., Birt, D., Gingell, R., Lawson, T., Nageal, D. and Wallcave, L. (1981) Current knowledge of pancreatic carcinogenesis in the hamster and its relative to the human disease. Cancer, 47, 1573-1589.
21. Mizumoto, K., Kitazawa, S., Ito, S., Takashima, Y., Tsutsumi, M., Denda, A. and Konishi, Y. (1989) Cycles of repeated augmentation pressure in rapid production of pancreatic and cholangiocellular carcinomas in hamsters initiated with N-nitrosobis(2-oxopropyl)amine. Carcinogenesis, 10, 1457-1459.
22. Mizumoto, K., Tsutsumi, M., Kitazawa, S., Denda, A. and Konishi, Y. (1988) Rapid production of pancreatic carcinoma by initiation with N-nitrosobis(2-oxopropyl)amine and repeated augmentation pressure in hamsters. J. Natl Cancer Inst., 80, 1564-1567.
23. Mizumoto, K., Tsutsumi, M., Kitazawa, S., Denda, A. and Konishi, Y. (1990) Usefulness of a rapid production model for pancreatic carcinoma in male hamsters. Cancer Lett., 49, 211-215.
24. Solt, D. and Farber, E. (1976) New principle for the analysis of chemical carcinogenesis. Nature, 263, 701-703.
25. Pilot, H.C., Barsness, L. and Goldworthy, T. (1978) Biochemical characterization of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine. Nature, 271, 456-458.
26. Konishi, Y., Tsutsumi, M. and Tsujiuchi, T. (1998) Mechanistic analysis of pancreatic ductal carcinogenesis in hamsters. Pancreas, 16, 300-306.
27. Mori, T., Tsutsumi, M., Noguchi, O., Horiguchi, K., Hohnoki, K., Okita, S., Suzuki, F. and Konishi, Y. (1994) Characterization of three cloned cell lines from a N-nitrosobis(2-hydroxypropyl)amine-induced transplantable hamster pancreatic ductal adenocarcinoma. Int. J. Pancreatol, 16, 171-177.
28. Egawa, S., Tsutsumi, M. and Konishi, Y. (1995) The role of angiogenesis in the tumor growth of Syrian hamster pancreatic cancer cell line HPD-NR. Gastroenterology, 108, 1526-1533.
29. Kido, A., Tsutsumi, M., Iki, K., Motoyama, M., Takahama, M., Tsujiuchi, T., Morishita, T., Tatsumi, K., Tamai, S. and Konishi, Y. (1999) Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4- dihydrocarbostyril, a novel matrix inhibitor. Jpn J. Cancer Res., 90, 333-341.
30. Cathala, G., Savouret, J.F., Mendez, B., West, D.L., Martial, J.A. and Baxter, J.P. (1983) Laboratory methods. A method for isolation of intact transcriptionally active ribonucleic acid. DNA, 2, 329-335.
31. Nakajima, I.A., Sasaguri, S., Nagase, H. and Mori, Y. (1995) Coculture of human breast adenocarcinoma MCF-7 cells and human dermal fibroblasts enhance the production of matrix metalloproteinases 1, 2 and 3 in fibroblasts. Br. J. Cancer, 71, 1039-1045.
32. Nomura, H., Fujimoto, N., Seiki, M., Mai, M. and Okida, Y. (1996) Enhanced production of matrix metalloproteinases and activation of matrix metalloproteinase 2 (gelatinase A) in human gastric carcinomas. Int. J. Cancer, 69, 9-16.
33. Konishi, Y., Mizumoto, K., Kitazawa, S., Tsujiuchi, T., Tsutsumi, M. and Kamano, T. (1990) Early ductal lesions of pancreatic carcinogenesis in animals and hamsters. Int. J. Pancreatol., 7, 83-89.
34. Sugimura, T., Sugano, H., Terada, M., Stemmermann, G.N., Yasui, W. and Tahara, E. (1994) First international workshop of the Princess Takamastu Cancer Research Fund: intestinal metaplasia and gastric cancer. Mol. Carcinog., 11, 1-7.
35. Tsutsumi, M., Kondoh, S., Noguchi, O., Horiguchi, K., Kobayashi, E., Okita, S., Ohashi, K., Hohnoki, K., Tsujiuchi, T. and Konishi, Y. (1993) K-ras gene mutation in early ductal lesions induced in rapid production model for pancreatic carcinomas in Syrian hamsters. Jpn J. Cancer Res., 84, 1101-1105.
36. Tsutsumi, M., Murakami, Y., Kondoh, S., Tsujiuchi T., Hohnoki, K., Noguchi, O., Kobayashi, E., Okita, S., Sekiya, T. and Konishi, Y. (1993) Comparison of K-ras oncogene activation in pancreatic duct carcinomas and cholangiocarcinomas induced in hamsters by N-nitrosobis(2-oxopropyl)amine. Jpn J. Cancer Res., 84, 956-960.
37. Okita, S., Tsutsumi, M., Onji, M. and Konishi, Y. (1995) p53 mutation without allelic loss and absence of mdm-2 amplification in a transplantable hamster pancreatic ductal adenocarcinoma and derived cell lines but not primary ductal adenocarcinomas in hamsters. Mol. Carcinog., 13, 266-271.
38. Kobitsu, K., Tsutsumi, M., Tsujiuchi, T., Suzuki, F., Kido, E., Okajima, T., Fukuda, T., Sakaki, T. and Konishi, Y. (1997) Shortened telomerase length and increased telomerase activity in hamster pancreatic duct adenocarcinomas and cell lines. Mol. Carcinog., 18, 153-159.