"MacroLH": Anomalous Molecular Form That Behaves as a Complex of Luteinizing Hormone (LH) and IgG in a Patient with Unexpectedly High LH Values

Clinical Chemistry

Volumn 49, Issue 12, 2003, Pages 2104-2105

  Henriques Vieira, José Gilberto ^a   Kiiomi Nishida, Sônia ^a   Faria De Camargo, Maria Teresa ^a   Magid Hauache, Omar ^a   De Barros Maciel, Rui Monteiro ^a   Guimarães, Valéria ^b  

^a Fleury   (Brazil)

^b Endocrinologia e Nefrologia   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; ENZYME ANTIBODY; ESTRADIOL; FOLLITROPIN; IMMUNOGLOBULIN G; LUTEINIZING HORMONE; MACROGOL; PROLACTIN; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; UNCLASSIFIED DRUG;

ADULT; ALPHA CHAIN; CASE REPORT; CHEMOLUMINESCENCE; CONGENITAL ADRENAL HYPERPLASIA; ELUTION; FEMALE; FLUOROMETRY; GEL FILTRATION CHROMATOGRAPHY; HASHIMOTO DISEASE; HORMONE BLOOD LEVEL; HUMAN; IMMUNOREACTIVITY; LABORATORY TEST; LETTER; MOLECULAR WEIGHT; PRECIPITATION;

ADRENAL HYPERPLASIA, CONGENITAL; ADULT; CHEMILUMINESCENT MEASUREMENTS; CHROMATOGRAPHY, GEL; FEMALE; FLUOROIMMUNOASSAY; HUMANS; IMMUNOGLOBULIN G; LUTEINIZING HORMONE; THYROIDITIS, AUTOIMMUNE;

EID: 0345376976     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2003.024992     Document Type: Letter

References (6)

1. Cavaco B, Leite V, Santos AM, Arranhado E, Sobrinho LG. Some forms of big-big prolactin behave as complex of monomeric prolactin with an immunoglobulin G in patients with macroprolactin or prolactinoma. J Clin Endocrinol Metab 1995;80:2342-6.
2. Bjoro I, Morkrid K, Wereland R, Turter A, Kvistborg A, Sand T, et al. Frequency of hyperprolactinemia due to large molecular weight prolactin (150-170 kDa PRL). Scand J Clin Invest 1995;55:139-47.
3. Fahie-Wilson MN, Soule SG. Macroprolactinemia: contribution to hyperprolactinemia in a district general hospital and evaluation of a screening test based upon precipitation with polyethylene glycol. Ann Clin Biochem 1997;34:252-8.
4. Bifulco M, Spitz I, Hirch HJ, Shorer Z, Aloj SM. High molecular-weight serum thyrotropin revisited. N Engl J Med 1987;316:1609-10.
5. Sapin R, d'Herbomez M, Schlienger JL, Wemeau JL. Anti-thyrotropin antibody interference in thyrotropin assays. Clin Chem 1998;44:2557-9.
6. Vieira JGH, Tachibana TT, Obara LH, Maciel RMB. Extensive experience and validation of polyethylene glycol precipitation as a screening method for macroprolactinemia. Clin Chem 1998;44:1758-9.