Maracin and maracen: New types of ethynyl vinyl ether and α-chloro divinyl ether antibiotics from Sorangium cellulosum with specific activity against mycobacteria

Angewandte Chemie - International Edition

Volumn 37, Issue 9, 1998, Pages 1253-1255

  Herrmann, Martina ^a   Böhlendorf, Bettina ^a,b   Irschik, Herbert ^c   Reichenbach, Hans ^c   Höfle, Gerhard ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

^c NONE

Author keywords

Antibiotics; Myxobacteria; Natural products; Structure elucidation; Vinyl ethers

Indexed keywords

ACETIC ACID; ALPHA CHLORO DIVINYL ETHER; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SYNTHESIS; ETHYNYL VINYL ETHER; MARACEN; MARACIN; MYCOBACTERIUM TUBERCULOSIS;

SORANGIUM CELLULOSUM;

EID: 0345367997     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(19980518)37:9<1253::AID-ANIE1253>3.0.CO;2-T     Document Type: Article

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7. In addition to the main components, the following side products were isolated: So ce880: maracin B (95 mg, 19,20-dihydro derivative of 1), maracin C (15 mg, (17Z) isomer of 1), maracin D (20 mg, (17Z) isomer of maracin B), maracin E (3 mg, (4Z) isomer of maracin B); So ce1128: maracen B (186 mg, 19,20-dihydro derivative of 2), maracen C (66 mg, (17Z) isomer of 2), maracen D (62 mg, (17Z) isomer of maracen B).
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