A hypothesis to explain the reduced blood levels of docosahexaenoic acid in inherited retinal degenerations caused by mutations in genes encoding retina-specific proteins

Lipids

Volumn 34, Issue 6 SUPPL., 1999, Pages

  Anderson, Robert E ^a,b,c   Maude, Maureen B ^a,b,c   Alvarez, Richard A ^a,b,c   Acland, Gregory ^d   Aguirre, Gustavo D ^d  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; PROTEIN;

ANTIOXIDANT ACTIVITY; CONFERENCE PAPER; GENE MUTATION; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; HYPOTHESIS; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIPID METABOLISM; PHOTORECEPTOR; RECEPTOR UPREGULATION; RETINA DEVELOPMENT;

EID: 0345280735     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02562304     Document Type: Conference Paper

References (25)

1. Converse, C., Hammer, H., Packard, C., and Shepherd, J. (1983) Plasma Lipid Abnormalities in Retinitis Pigmentosa and Related Conditions, Trans. Ophthalmol. Sci. UK 103, 508-512.
2. Converse, C., McLachlan, T., Bow, A., Packard, C., and Shepherd, J. (1987) Lipid Metabolism in Retinitis Pigmentosa, in Degenerative Retinal Disorders, Clinical and Laboratory Investigations (Hollyfield, J., Anderson, R., and LaVail, M., eds.) pp. 93-101, Alan R. Liss Inc., New York.
3. Anderson, R., Maude, M., Lewis, R., Newsome, D., and Fishman, G. (1987) Abnormal Plasma Levels of Polyunsaturated Fatty Acid in Autosomal Dominant Retinitis Pigmentosa, Exp. Eye Res. 44, 155-159.
4. Gong, J., Rosner, B., Rees, D., Berson, E., Weigel-DiFranco, C., and Schaefer, E. (1992) Plasma Docosahexaenoic Acid Levels in Various Genetic Forms of Retinitis Pigmentosa, Invest. Ophthalmol. Vis. Sci. 33, 2596-2602.
5. Hoffman, D., Uauy, R., and Birch, D. (1993) Red Blood Cell Fatty Acid Levels in Patients with Autosomal Dominant Retinitis Pigmentosa, Exp. Eye. Res. 57, 359-368.
6. Holman, R., Bibus, D., Jeffrey, G., Smethurst, P., and Crofts, J. (1994) Abnormal Plasma Lipids of Patients with Retinitis Pigmentosa, Lipids 29, 61-65.
7. Hoffman, D., and Birch, D. (1995) Docosahexaenoic Acid in Red Blood Cells of Patients with X-linked Retinitis Pigmentosa, Invest. Ophthalmol. Vis. Sci. 36, 1009-1018.
8. Bazan, N., Scott, B., Reddy, T., and Pelias, M. (1986) Decreased Content of Docosahexaenoate and Arachidonate in Plasma Phospholipids in Usher's Syndrome, Biochem. Biophys. Res. Comm. 141, 600-604.
9. Maude, M.B., Anderson, E.O., and Anderson, R.E. (1998) Polyunsaturated Fatty Acids Are Lower in Blood Lipids of Usher's Type I, but Not Usher's Type II, Invest. Ophthalmol. Vis. Sci. 39, 2164-2166.
10. Anderson, R., Maude, M., Alvarez, R., Acland, G., and Aguirre, G. (1991) Plasma Lipid Abnormalities in the Miniature Poodle with Progressive Rod-Cone Degeneration, Exp. Eye Res. 52, 349-355.
11. Aguirre, G., Alligood, J., O'Brien, P., and Buyukmichi, N. (1982) Pathogenesis of Progressive Rod-Cone Degeneration in Miniature Poodles, Invest. Ophthalmol. Vis. Sci. 23, 610-630.
12. Aguirre, G., Acland, G., Maude, M., and Anderson, R. (1997) Diets Enriched in Docosahexaenoic Acid Fail to Correct Progressive Rod-Cone Degeneration (prcd) Phenotype, Invest. Ophthalmol. Vis. Sci. 38, 2387-2407.
13. Alvarez, R., Aguirre, G., Acland, G., and Anderson, R. (1994) Docosapentaenoic Acid Is Converted to Docosahexaenoic Acid in the Retinas of Normal and prcd-Affected Miniature Poodle Dogs, Invest. Ophthalmol. Vis. Sci. 35, 402-408.
14. Anderson, R., and Maude, M. (1972) Lipids of Ocular Tissues: VII. The Effects of Essential Fatty Acid Deficiency on the Phospholipids of the Photoreceptor Membranes of Rat Retina, Arch. Biochem. Biophys. 151, 270-276.
15. Wiegand, R., Koutz, C., Chen, H., and Anderson, R. (1995) Effect of Dietary Fat and Environmental Lighting on the Phospholipid Molecular Species of Rat Photoreceptor Membranes, Exp. Eye Res. 60, 291-306.
16. Neuringer, M., Connor, W., Van Patten, C., and Barstad, L. (1984) Dietary Omega-3 Fatty Acid Deficiency and Visual Loss in Infant Rhesus Monkeys, J. Clin. Invest. 73, 272-276.
17. Neuringer, M., Connor, W., Lin, D., Barstad, L., and Luck, S. (1986) Biochemical and Functional Effects of Prenatal and Postnatal ω3 Fatty Acid Deficiency on Retina and Brain in Rhesus Monkeys, Proc. Natl. Acad. Sci. USA 83, 4021-4025.
18. Weisinger, H., Vingrys, A., and Sinclair, A. (1996) Effect of Dietary n-3 Deficiency on the Electroretinogram in the Guinea Pig, Ann. Nutr. Metab. 40, 91-98.
19. Weisinger, H., Vingrys, A., and Sinclair. A. (1996) The Effect of Docosahexaenoic Acid on the Electroretinogram of the Guinea Pig, Lipids 31, 65-70.
20. Galli, C., Trzeciak, H., and Paoletti, R. (1971) Effects of Dietary Fatty Acids on the Fatty Acid Composition of the Brain Ethanolamine Phosphoglyceride: Reciprocal Replacement of n-6 and n-3 Polyunsaturated Fatty Acids, Biochim. Biophys. Acta 248, 449-454.
21. Penn, J., and Anderson, R. (1987) Effect of Light History on Rod Outer-Segment Membrane Composition in the Rat, Exp. Eye Res. 44, 767-778.
22. Penn, J., Naash, M., and Anderson, R. (1987) Effect of Light History on Retinal Antioxidants and Light Damage Susceptibility in the Rat, Exp. Eye Res. 44, 779-788.
23. Penn, J., and Anderson, R. (1992) Effects of Light History on the Rat Retina, in Progress in Retinal Research (Osborne, N., and Chader, G., eds.) pp. 75-98, Pergamon Press, New York.
24. Penn, J., Thum, L., and Naash, M. (1989) Photoreceptor Physiology in the Rat Is Governed by the Light Environment, Exp. Eye Res. 49, 205-215.
25. Bazan, N.G., and Rodriguez de Turco, E.B. (1996) Alterations in Plasma Lipoproteins and DHA Transport in Progressive Rod-cone Degeneration (prcd) in Retinal Degeneration and Regeneration (Kato, S., Osborne, N.N., and Tamai, M., eds.) pp. 89-97, Kugler Publications, Amsterdam.