Use of incubation time to detection in BACTEC 9240 to distinguish coagulase-negative staphylococcal contamination from infection in pediatric blood cultures

Pediatric Infectious Disease Journal

Volumn 22, Issue 11, 2003, Pages 968-973

  Haimi Cohen, Yishai ^a   Shafinoori, Shideh ^a   Tucci, Victor ^b   Rubin, Lorry G ^a  

^a SCHNEIDER CHILDREN'S HOSPITAL   (United States)

^b LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

Bacteremia; Blood culture; Staphylococcus; Vascular catheter infection

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BACTERIAL GROWTH; BACTERIUM CONTAMINATION; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; BLOOD CULTURE; BLOOD VESSEL CATHETERIZATION; CHILD; CLINICAL ARTICLE; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; EVALUATION; HUMAN; INCUBATION TIME; INFANT; PREDICTION; PRIORITY JOURNAL; STAPHYLOCOCCUS INFECTION;

BACTEREMIA; BACTERIOLOGICAL TECHNIQUES; COAGULASE; CROSS INFECTION; CULTURE MEDIA; EQUIPMENT CONTAMINATION; HUMANS; PEDIATRICS; RETROSPECTIVE STUDIES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; STATISTICS, NONPARAMETRIC;

EID: 0345276613     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.inf.0000095195.60494.ba     Document Type: Article

References (25)

1. Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN, Wenzel RP. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis 1999;29:239-44.
2. McGowan KL, Foster JA, Coffin SE. Outpatient pediatric blood cultures: time to positivity. Pediatrics 2000;106:251-5.
3. Norberg A, Christopher NC, Ramundo ML, Bower JR, Berman SA. Contamination rates of blood cultures obtained by dedicated phlebotomy vs. intravenous catheter. JAMA 2003;289:726-9.
4. Thuler LCS, Jenicek M, Turgeon JP, Rivard M, Lebel P, Lebel MH. Impact of a false positive blood culture result on the management of febrile children. Pediatr Infect Dis J 1997;16:846-51.
5. Weinstein MP, Towns ML, Quartey SM, et al. The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 1997;24:585-602.
6. Lyytikainen O, Valtonen V, Antilla VJ, Tuutu P. Evaluation of clinical and laboratory findings in leukaemic patients with blood cultures positive for Staphylococcus epidermidis. J Hosp Infect 1998;38:27-35.
7. Waltzman ML, Harper M. Financial and clinical impact of false-positive blood culture results. Clin Infect Dis 2001;33:296-9.
8. St Geme III JW, Bell LM, Baumgart S, D'Angio CT, Harris MC. Distinguishing sepsis from blood culture contamination in young infants with blood cultures growing coagulase-negative staphylococci. Pediatrics 1990;86:157-62.
9. Phillips SE, Bradley JS. Bacteremia detected by direct plating in a neonatal intensive care unit. J Clin Microbiol 1990;28:1-4.
10. Ruderman JW, Morgan MA, Klein AH. Quantitative blood cultures in the diagnosis of sepsis in infants with umbilical and Broviac catheters. J Pediatr 1988;112:748-51.
11. Capdevila JA, Planes AM, Palomar M, et al. Value of differential quantitative blood cultures in the diagnosis of catheter-related sepsis. Eur J Clin Microbiol Infect Dis 1992;11:403-7.
12. Blot F, Nitenberg G, Chachaty E, et al. Diagnosis of catheter-related bacteremia: A prospective comparision of the time to positivity of hub-blood versus peripheral-blood cultures. Lancet 1999;354:1071-7.
13. Doern GV, Barton A, Rao S. Controlled comparative evaluation of BacT/Alert FAN and ESP 80A aerobic media as means for detecting bacteremia and fungemia. J Clin Microbiol 1988;36:2686-9.
14. Haimi-Cohen S, Vellozzi EM, Rubin LG. Initial bacterial concentration of Staphylococcus epidermidis in simulated pediatric blood cultures correlates with incubation time to positive using the automated, continuously monitored blood culture system Bactec 9240. J Clin Microbiol 2002;40:898-901.
15. Blot F, Schmidt E, Nitenberg G, et al. Earlier positivity of central-venous versus peripheral-blood cultures is highly predictive of catheter-related sepsis. J Clin Microbiol 1998;36:105-9.
16. Rogers MS, Oppenheim BA. The use of continuous monitoring blood culture systems in the diagnosis of catheter related sepsis. J Clin Pathol 1988;51:635-7.
17. Mermel LA, Farr BM, Sherertz RJ, et al. Guidelines for the management of intravascular catheter-related infections. Clin Infect Dis 2001;32:1249-72.
18. Maki DG, Weise CE, Sarafin HW. A semiquantitative culture method for identifying catheter-related infection. N Engl J Med 1977;296:1305-9.
19. Herwaldt LA, Geiss M, Kao C, Pfaller MA. The positive predictive value of isolating coagulase-negative staphylococci from blood cultures. Clin Infect Dis 1996;22:14-20.
20. DesJardin JA, Falagas ME, Ruthazer R, et al. Clinical utility of blood cultures drawn from indwelling central venous catheters in hospitalized patients with cancer. Ann Intern Med 1999;131:641-7.
21. Sharma M, Riederer K, Johnson LB, Khatib R. Molecular analysis of coagulase-negative staphylococci from blood cultures: prevalence of genotypic variation and polyclonal bacteremia. Clin Infect Dis 2001;33:1317-23.
22. Kim SDK, McDonald C, Jarvis WR, et al. Determining the significance of coagulase-negative staphylococci isolated from blood cultures at a community hospital: a role for species and strain identification. Infect Control Hosp Epidemiol 2000;21:213-7.
23. Seo SK, Venkataraman L, DeGirolami PC, Samore MH. Molecular typing of coagulase-negative staphylococci from blood cultures does not correlate with clinical criteria for true bacteremia. Am J Med 2000;106:697-704.
24. Rubin LG, Sanchez PJ, Siegel JD, et al. Evaluation and treatment of neonates with suspected late-onset sepsis (LOS): a survey of neonatologists' practices. Pediatrics 2002;110:URL: http://www.pediatrics.org/cgi/content/full/110/4/e42.
25. Haimi-Cohen S, Rubin LG. Time to detection in Bactec 9240 helps to distinguish coagulase-negative staphylococcal contamination from infection in blood cultures [Abstract]. In: 36th Annual Meeting of the Infectious Diseases Society of America, Philadelphia, November 18 to 20, 1999. Alexandria, VA: Infectious Diseases Society of America, 1999.