A convenient method for asymmetric alkylation of glycine imine esters using solid supports

Tetrahedron Letters

Volumn 44, Issue 51, 2003, Pages 9209-9211

  Yu, Haitao ^a   Koshima, Hideko ^a  

^a EHIME UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM OXIDE; BENZOPHENONE; ESTER DERIVATIVE; GLYCINE DERIVATIVE; IMINE; SCHIFF BASE;

ALKYLATION; ARTICLE; CHIRALITY; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICROWAVE IRRADIATION; ROOM TEMPERATURE;

EID: 0345276523     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.10.023     Document Type: Article

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13. Support/KOH was prepared as follow: Support (alumina, montmorillonite K-10 or kaolin clay) (3 g) was added to 4 mL of 25% KOH solution, and the mixture was sonicated for a period of 4 h. The water was removed under reduced pressure. The resultant solids were irradiated with microwave for 15 min and ground to a powder.
14. 2 (0.2 mL) was dispersed on alumina/KOH (0.5 g, 51 equiv. KOH to 1 ). After evaporation of the solvent, the so-obtained mixture was irradiated by microwave with a Sanyo EM-LA1 (500 W) for appropriate minutes. The separation is the same as above.