Genetic susceptibility for lung cancer: Interactions with gender and smoking history and impact on early detection policies

Human Heredity

Volumn 56, Issue 1-3, 2003, Pages 139-145

  Gorlova, Olga Y ^a   Amos, Christopher ^a   Henschke, Claudia ^c   Lei, Lei ^a   Spitz, Margaret ^a   Wei, Qingyi ^a   Wu, Xifeng ^a   Kimmel, Marek ^b,d  

^a UNIVERSITY OF TEXAS   (United States)

^b RICE UNIVERSITY   (United States)

^c WEILL CORNELL MEDICAL CENTER   (United States)

^d Rice University   (United States)

Author keywords

DNA repair capacity; Gender; Genetic susceptibility; Lung cancer; Mass screening; Mathematical modeling; Mutagen sensitivity; Smoking history

Indexed keywords

BLEOMYCIN; DNA;

ANAMNESIS; CANCER SCREENING; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FEMALE; GENETIC IDENTIFICATION; GENETIC SUSCEPTIBILITY; HEALTH CARE POLICY; HIGH RISK POPULATION; HUMAN; LIFESPAN; LUNG CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOLECULAR INTERACTION; MORTALITY; PROBABILITY; SEX DIFFERENCE; SMOKING HABIT;

AGE OF ONSET; EARLY DIAGNOSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LUNG NEOPLASMS; MALE; MONTE CARLO METHOD; RISK FACTORS; SMOKING;

EID: 0345257818     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000073742     Document Type: Conference Paper

References (18)

1. Amos CI, Wu X, Spitz MR: Is there a genetic basis for lung cancer susceptibility? Recent Results Cancer Res 1999;151:3-12.
2. Hsu TC, Spitz MR, Schantz SP: Mutagen sensitivity: a biologic marker of cancer susceptibility. Cancer Epidemiol Biomarkers Prev 1991;1:83-89.
3. Wei Q, Cheng L, Amos CI, Wang LE, Guo Z, Hong WK, Spitz MR: Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study. J Natl Cancer Inst 2000;92:1764-1772.
4. Berwick M, Vineis P: Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. J Natl Cancer Inst 2000;92:874-897.
5. Wu X, Gu J, Amos CI, Jiang H, Hong WK, Spitz MR: A parallel study of in vitro sensitivity to benzo[a]pyrene diol epoxide and bleomycin in lung carcinoma cases and controls. Cancer 1998;83:1118-1127.
6. Spitz MR, Wu X, Wang Y, Wang LE, Shete S, Amos CI, Guo Z, Lei L, Mohrenweiser H, Wei Q: Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. Cancer Res 2001;61:1354-1357.
7. Cloos J, Nieuwenhuis EJ, Boomsma DI, Kuik DJ, van der Sterre ML, Arwert F, Snow GB, Braakhuis BJ: Inherited susceptibility to bleomycin-induced chromatid breaks in cultured peripheral blood lymphocytes. J Natl Cancer Inst 1999;91:1125-1130.
8. Qiao Y, Spitz MR, Guo Z, Hadeyati M, Grossman L, Kraemer KH, Wei Q: Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes. Mutat Res 2002;509:165-174.
9. Hudmon KS, Honn SE, Jiang H, Chamberlain RM, Xiang W, Ferry G, Gosbee W, Hong WK, Spitz MR: Identifying and recruiting healthy control subjects from a managed care organization: a methodology for molecular epidemiological case-control studies of cancer. Cancer Epidemiol Biomarkers Prev 1997;6:565-571.
10. Thun MJ, Henley SJ, Calle EE: Tobacco use and cancer: an epidemiologic perspective for geneticists. Oncogene 2002;21:7307-7325.
11. Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R: Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ 2000;321:323-329.
12. Flehinger BJ, Kimmel M: The natural history of lung cancer in a periodically screened population. Biometrics 1987;43:127-144.
13. Gorlova OY, Kimmel M, Henschke C: Modeling of long-term screening for lung carcinoma. Cancer 2001;92:1531-1540.
14. Henschke CI, McCauley DI, Yankelevitz DF, Naidich DP, McGuinness G, Miettinen OS, Libby DM, Pasmantier MW, Koizumi J, Altorki NK, Smith JP: Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet 1999;354:99-105.
15. Mountain CF: Revisions in the International System for Staging Lung Cancer. Chest 1997;111:1710-1717.
16. Inoue K, Sato M, Fujimura S, Sakurada A, Takahashi S, Usuda K, Kondo T, Tanita T, Handa M, Saito Y, Sagawa M: Prognostic assessment of 1310 patients with non-small-cell lung cancer who underwent complete resection from 1980 to 1993. J Thorac Cardiovasc Surg 1998;116:407-411.
17. Flehinger BJ, Kimmel M, Polyak T, Melamed MR: Screening for lung cancer. The Mayo Lung Project revisited. Cancer 1993;72:1573-1580.
18. Fontana RS, Sanderson DR, Taylor WF, Woolner LB, Miller WE, Muhm JR, Uhlenhopp MA: Early lung cancer detection: results of the initial (prevalence) radiologic and cytologic screening in the Mayo Clinic study. Am Rev Respir Dis 1984;130:561-565.