Carvedilol, an antihypertensive drug with antioxidant properties, protects against glycerol-induced acute renal failure

American Journal of Nephrology

Volumn 23, Issue 6, 2003, Pages 415-421

  Singh, Devinder ^a   Chander, Vikas ^a   Chopra, Kanwaljit ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Acute renal failure; Carvedilol; Glycerol induced acute renal failure; Oxidative stress; Rhabdomyolysis

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTIOXIDANT; CARVEDILOL; CATALASE; CREATININE; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLYCEROL; MALONALDEHYDE; SUPEROXIDE DISMUTASE; UREA;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; FENTON REACTION; KIDNEY FUNCTION; KIDNEY INJURY; MALE; MOLECULAR INTERACTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; CARBAZOLES; DISEASE MODELS, ANIMAL; GLYCEROL; KIDNEY; KIDNEY FAILURE, ACUTE; KIDNEY FUNCTION TESTS; MALE; OXIDATIVE STRESS; PROPANOLAMINES; RATS; RATS, WISTAR;

EID: 0345257791     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074453     Document Type: Article

References (37)

1. Knochel JP: Mechanisms of rhabdomyolysis. Curr Opin Rheumatol 1993;5:725-731.
2. Zager RA: Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int 1996;49:314-326.
3. Stefanovic V, Savic V, Vlahovic P, Cvetkovic T, Najman S, Mitic-Zlatkovic M: Reversal of experimental myoglobinuric acute renal failure with bioflavonoids from seeds of grape. Ren Fail 2000;22:255-266.
4. Beetham R: Biochemical investigation of suspected rhabdomyolysis. Ann Clin Biochem 2000;37:581-587.
5. Paller MS: Hemoglobin- and myoglobin-induced acute renal failure in rats: Role of iron in nephrotoxicity. Am J Physiol 1988;255:F539-F544.
6. Halliwell B, Gutteridge JMC: Role of free radicals and catalytic metal ions in human disease: An overview. Methods Enzymol 1990;186:1-85.
7. Zager RA: Rhabdomyolysis and myoglobinuric acute renal failure. Kidney Int 1996;49:314-325.
8. Baliga R, Ueda N, Walker PD, Shah SV: Oxidant mechanisms in toxic acute renal failure. Am J Kidney Dis 1996;29:465-477.
9. Chander V, Singh D, Chopra K: Attenuation of glycerol-induced acute renal failure in rats by trimetazidine and deferoxamine. Pharmacology 2003;67:41-48.
10. Feuerstein R, Yue TL: A potent antioxidant, SB209995, inhibits oxygen-radical-mediated lipid peroxidation and cytotoxicity. Pharmacology 1994;48:385-391.
11. Yue TL, Cheng HY, Lysko PG, McKenna PJ, Feuerstein R, Gu JL, Lysko KA, Davis LL, Feuerstein G: Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger. J Pharmacol Exp Ther 1992;263:92-98.
12. Yue TL, McKenna PJ, Lyskom PG, Ruffolo RR, Feuerstein GZ: Carvedilol, a new antihypertensive, prevents oxidation of human low density lipoprotein by macrophages and copper. Atherosclerosis 1992;97:209-216.
13. Yue TL, McKenna PJ, Ruffolo RR, Feuerstein G: Carvedilol, a new beta-adrenoceptor antagonist and vasodilator antihypertensive drug, inhibits superoxide release from human neutrophils. Eur J Pharmacol 1992;214:277-280.
14. Yue TL, McKenna PJ, Gu JL, Cheng HY, Ruffolo RR, Feuerstein GZ: Carvedilol, a new antihypertensive agent, prevents lipid peroxidation and oxidative injury to endothelial cells. Hypertension 1993;22:922-928.
15. Tadolini B, Franconi F: Carvedilol inhibition of lipid peroxidation. A new antioxidative mechanism. Free Radic Res 1998;29:377-387.
16. Noguchi N, Nishino K, Niki E: Antioxidant action of the antihypertensive drug, carvedilol, against lipid peroxidation. Biochem Pharmacol 2000;59:1069-1076.
17. Cargnoni A, Ceconi C, Bernocchi P, Boraso A, Parrinello G, Curello S, Ferrari R: Reduction of oxidative stress by carvedilol: Role in maintenance of ischaemic myocardium viability. Cardiovasc Res 2000;47:556-566.
18. Feuerstein GZ, Ruffolo RR Jr: Carvedilol, a novel vasodilating beta-blocker with the potential for cardiovascular organ protection. Eur Heart J 1996;17(suppl B):24-29.
19. Brooks DP, Short BG, Cyronak MJ, Contino LC, DiCristo M, Wang Y-X, Ruffolo RR Jr: Comparison between carvedilol and captopril in rats with partial ablation-induced chronic renal failure. Br J Pharmacol 1993;109:581-586.
20. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biocem 1979;95:351-358.
21. Varley H: The plasma proteins; in Varley H (ed): Practical Clinical Biochemistry. Delhi, CBS, 1988, pp 236-238.
22. Jollow DJ, Mitchell LR, Zampaglione N, Gillette JR: Bromobenzene-induced liver necrosis: Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic intermediate. Pharmacology 1974;11:151-169.
23. Carlberg I, Mannerviek B: Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J Biol Chem 1975;250:5475-5490.
24. Mohandas J, Marshall JJ, Duggin GG, Horvath JS, Tiller D: Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer. Cancer Res 1984;44:5086-5091.
25. Claiborne A: Catalase activity; in Greenwald RA (ed): CRC Handbook of Methods for Oxygen Radical Research. Boca Raton, CRC, 1985, pp 283-284.
26. Kono Y: Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 1978;186:189-195.
27. Homsi E, Oliveira EP, Garcia WE, Gontijo JS, Figueiredo JF: Effects of nifedipine and platelet activating factor antagonist (BN 52021) in glycerol-induced acute renal faliure in rats. Ren Fail 1996;18:883-892.
28. Dubrow A, Flamenbaum W: Acute renal failure associated with myoglobinuria and hemoglobinuria; in Soles K, Whelton A (eds): Acute Renal Failure. New York, Marcel Dekker, 1983, pp 279-293.
29. Halliwell B, Gutteridge JMC: Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 1984;219:1-14.
30. Sadrzadeh SMH, Anderson DK, Panter SS, Hallaway PE, Eaton JW: Hemoglobin potentiates central nervous system damage. J Clin Invest 1987;79:662-664.
31. Williams RE, Zweier JL, Flaherty JT: Treatment with deferoxamine during ischemia improves functional and metabolic recovery and reduces reperfusion-induced oxygen radical generation in rabbit hearts. Circulation 1991;83:1006-1014.
32. Oken DE, Arce ML, Wilson DR: Glycerol-induced hemoglobinuric acute renal failure in the rat. I. Micropuncture study of the development of oliguria. J Clin Invest 1966;45:724-735.
33. Baud L, Ardaillou R: Involvement of reactive oxygen species in kidney damage. Br Med Bull 1993;49:621-629.
34. Bomzon A, Holt S, Moore K: Bile acids, oxidative stress, and renal function in biliary obstruction. Semin Nephrol 1997;17:549-562.
35. Mak TI, Weglicki JJ: Protection by β-blocking agents against free radical mediated sarcolemmal lipid peroxidation. Circ Res 1988;63:262-266.
36. Preece NE, Evans, PE, Howarth JA, King LJ, Parke DV: The induction of antioxidative tissue damage by iron nitrilotriacetate in rats and mice. Toxicol Appl Pharmacol 1988;93:89-100.
37. Umemura TY, Sai K, Takagi A, Hasegawa R, Kurokawa Y: Formation of 8-hydroxydeoxy-guanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA). Carcinogenesis 1990;11:345-347.