Therapy-related leukemia cutis: Case study of an aggressive disorder

Annals of Hematology

Volumn 82, Issue 11, 2003, Pages 705-707

  Zebisch, A ^a   Cerroni, L ^a   Beham Schmid, C ^a   Sill, Heinz ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Allogeneic transplantation; Leukemia cutis; Microsatellite instability; Therapy related neoplasia; TP53

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; CYTARABINE; DNA; DOXORUBICIN; FLUDARABINE; IDARUBICIN; MITOXANTRONE; PREDNISONE; T LYMPHOCYTE RECEPTOR; VINCRISTINE;

ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CASE REPORT; CAUSE OF DEATH; CERVICAL LYMPH NODE; CLINICAL FEATURE; GENETIC ANALYSIS; GENETIC SCREENING; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; LEUKEMIA; LYMPH NODE METASTASIS; MALE; MISMATCH REPAIR; MYELODYSPLASIA; NATURAL KILLER CELL; NONHODGKIN LYMPHOMA; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SKIN BIOPSY; SKIN CANCER; T CELL LYMPHOMA; WHOLE BODY RADIATION;

BASE PAIR MISMATCH; DNA REPAIR; FATAL OUTCOME; GENES, P53; HUMANS; LEUKEMIA, SUBLEUKEMIC; LEUKEMIC INFILTRATION; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; MUTATION; PEROXIDASE; SKIN;

EID: 0345257026     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-003-0717-y     Document Type: Article

References (13)

1. Baer MR, Barcos M, Farrell H, Raza A, Preisler HD (1989) Acute myelogenous leukaemia with leukemia cutis. Cancer 63:2192-2200
2. Ben-Yehuda D, Krichevsky S, Caspi O, Rund D, Polliack A, Abeliovich D, Zelig O, Yahalom V, Paltiel O, Or R, Peretz T, Ben-Neriah S, Yehuda O, Rachmilewitz EA (1996) Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype. Blood 88:4296-4303
3. Byrd JC, Edenfield WJ, Shields DJ, Dawson NA (1995) Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol 13:1800-1816
4. Christiansen DH, Andersen MK, Pedersen-Bjergaard J (2001) Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis. J Clin Oncol 19:1405-1413
5. Das-Gupta EP, Seedhouse CH, Russell NH (2001) Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia. Br J Haematol 114:307-312
6. Greenblatt MS, Benett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878
7. Husak R, Blume-Peytaki U, Orfanos CE (1999) Aleukemic leukemia cutis in an adolescent boy. N Engl J Med 340:893-894
8. Kaddu S, Zenahlik P, Beham-Schmid C, Kerl H, Cerroni L (1999) Specific cutaneous infiltrates in patients with myelogenous leukemia: a clinicopathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol 40:966-978
9. Ohno S, Yokoo T, Ohta M, Yamamoto M, Danno K, Hamato N, Tomii K, Ohno Y, Kobashi Y (1990) Aleukemic leukemia cutis. J Am Acad Dermatol 22:374-377
10. Olipitz W, Hopfinger G, Aguiar RCT, Gunsilius E, Girschikofsky M, Bodner C, Hiden K, Linkesch W, Hoefler G, Sill H (2002) Defective DNA-mismatch repair: a potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia. Genes Chromosomes Cancer 34:243-248
11. Pedersen-Bjergaard J, Andersen MK, Christiansen DH, Nerlov C (2002) Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. Blood 99:1909-1912
12. Shaikh BS, Frantz E, Lookingbill DP (1987) Histologically proven leukemia cutis carries a poor prognosis in acute nonlymphocytic leukemia. Cutis 39:57-60
13. Smith SM, Le Beau MM, Huo D, Karrison T, Sobecks RM, Anastasi J, Vardiman JW, Rowley JD, Larson RA (2003) Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood 102:43-52.