Sex differences in African-Americans regarding sensitivity to insulin's glucoregulatory and antilipolytic actions

Diabetes Care

Volumn 22, Issue 1, 1999, Pages 71-77

  Sumner, Anne E ^a,b   Tulenko, Thomas N ^a   Kushner, Harvey ^a   Falkner, Bonita ^a   Sherif, Katherine D ^a   Marsh, Julian B ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMAN; INSULIN SENSITIVITY; LIPOLYSIS; MAJOR CLINICAL STUDY; MALE; NEGRO; OBESITY; ORAL GLUCOSE TOLERANCE TEST; SEX DIFFERENCE;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ANALYSIS OF VARIANCE; BLOOD GLUCOSE; COHORT STUDIES; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HUMANS; HYPERINSULINISM; INFUSIONS, INTRAVENOUS; INSULIN; LIPOLYSIS; LONGITUDINAL STUDIES; MALE; METABOLIC CLEARANCE RATE; PHILADELPHIA; REGRESSION ANALYSIS; SEX CHARACTERISTICS;

EID: 0345251957     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.22.1.71     Document Type: Article

References (27)

1. Cooper RS, Rotimi CN, Kaufman JS, Owoaje EE, Fraser H, Forrester T, Wilks R, Riste LK, Cruickshank JK: Prevalence of NIDDM among populations of the African diaspora. Diabetes Care 20:343-348, 1997
2. Kumanyika SK: Special issues regarding obesity in minority populations. Ann Intern Med 119:650-654, 1993
3. Laws A, Hoen HM, Selby JV, Saad MF, Haffner SM, Howard BV: Differences in insulin suppression of free fatty acid levels by gender and glucose tolerance status. Arterioscler Thromb Vasc Biol 17:64-71, 1997
4. McKeigue PM, Laws A, Chen YD, Marmot MG, Reaven GM: Relation of plasma triglyceride and apoB levels to insulin-mediated suppression of nonesterified fatty acids. Arterioscler Thromb 13:1187-1192, 1993
5. Sumner AE, Kushner H, Tulenko TN, Falkner B, Marsh JB: The relationship in African-Americans of sex differences in insulin-mediated suppression of nonesterified fatty acids to sex differences in fasting triglyceride levels. Metabolism 46:400-405, 1997
6. Bakir SM, Jarrett RJ: The effects of a low-dose intravenous infusion upon plasma glucose and non-esterified fatty acid levels in very obese and non-obese subjects. Diabetologia 20:592-596, 1981
7. Falkner B, Kushner H, Tulenko T, Sumner AE, Marsh JB: Insulin sensitivity, lipids and blood pressure in young American blacks. Arterioscler Thromb Vasc Biol 15:1798-1804, 1995
8. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1197, 1997
9. Womersley J, Dumin JVGA: A comparison of the skinfold method with the extent of 'overweight' and various weight-height relationships in the assessment of obesity. Br J Nutr 38:271-284, 1977
10. Falkner B, Hulman S, Kushner H: Gender differences in insulin-stimulated glucose utilization among African-Americans. Am J Hypertens 7:948-953, 1994
11. Rizza RA, Mandarino LJ, Gerich JE: Dose-response characteristics for the effects of insulin on production and utilization of glucose in man. Am J Physiol 240:E630-E639, 1981
12. DeFronzo R, Tobin J, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223, 1979
13. National Center for Health Statistics: Health, United States, 1990. Washington, DC, U.S. Govt. Printing Office, 1991 (DHHS publ. no. [PHS] 91-1232)
14. Banerji MA, Lebowitz J, Chaiken RL, Gordon D, Kral JG, Lebovitz HE: Relationship of visceral adipose tissue and glucose disposal is independent of sex in black NIDDM subjects. Am J Physiol 273:E425-E432, 1997
15. Zamboni M, Armellini F, Harris T, Turcato E, Micciolo R, Bergamo-Andreis IA, Bosello O: Effects of age on body fat distribution and cardiovascular risk factors in women. Am J Clin Nutr 66:111-115, 1997
16. McNeill G, Fowler PA, Maughan RJ, McGaw BA, Fuller MF, Gvozdanovic D, Gvozdanovic S: Body fat in lean and overweight women estimated by six methods. Br J Nutr 65:95-103, 1991
17. Brodowicz GR, Mansfield RA, McClung MR, Althoff SA: Measurement of body composition in the elderly: dual energy x-ray absorptiometry, underwater weighing, bioelectrical impedance analysis and anthropometry. Gerontology 40:332-339, 1994
18. Yeaman SJ, Smith GM, Jepson CA, Wood SL, Emmison N: The multifunctional role of hormone-sensitive lipase in lipid metabolism. Adv Enzyme Regul 34:355-370, 1994
19. Sumner AE, Kushner H, Lakota CA, Falkner B, Marsh JB: Gender differences in insulin-induced free fatty acid suppression: studies in an African-American population. Lipids 31 (Suppl.):S275-S278, 1996
20. Howard BV, Klimes I, Vasquez B, Brady D, Nagulesparan M, Unger RH: The antilipolytic action of insulin in obese subjects with resistance to its glucoregulatory action. J Clin Endocrinol Metab 58:544-548, 1984
21. Havel RJ, Kane JP, Balasse EO, Segel N, Basso LV: Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J Clin Invest 49:2017-2035, 1970
22. Yki-Jarvinen H, Taskinen M-R: Interrelationships among insulin's antilipolytic and glucoregulatory effects and plasma triglycerides in nondiabetic and diabetic patients with endogenous hypertriglyceridemia. Diabetes 37:1271-1278, 1988
23. Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose fatty-acid cycle, its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i:785-789, 1963
24. Boden G, Chen X, Ruiz J, White JV, Rossetti L: Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446, 1994
25. Kruszynska YT, Mulford MI, Yu JG, Armstrong DA, Olefsky JM: Effects of nonesterified fatty acids on glucose metabolism after glucose ingestion. Diabetes 46:1586-1593, 1997
26. Ferrannini E, Barrett EJ, Bevilacqua S: Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72:1737-1747, 1983
27. Saloranta C, Koivisto V, Widen E, Falholt K, DeFronzo RA, Harkonen M, Groop L: Contribution of muscle and liver 10 glucose-fatty acid cycle in humans. Am J Physiol 264:E599-E605, 1993