Preparation of and fluoroalkylation with (chlorodifluoromethyl)trimethylsilane, difluorobis(trimethylsilyl)methane, and 1,1,2,2-tetrafluoro-1,2-bis(trimethylsilyl)ethane

Journal of the American Chemical Society

Volumn 119, Issue 7, 1997, Pages 1572-1581

  Yudin, Andrei K ^b   Prakash, G K Surya ^b   Deffieux, Denis ^a,b   Bradley, Michael ^b   Bau, Robert ^b   Olah, George A ^b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANOFLUORINE DERIVATIVE; SILANE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; FLUORINATION; IN VITRO STUDY; METHODOLOGY; REACTION ANALYSIS;

EID: 0345244392     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja962990n     Document Type: Article

References (39)

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36. 3SiCl, see ref 27.
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38. A series of (perfluoroalkyl)trialkylsilanes were purified by partitioning between 98% sulfuric acid and hexane: Sekya A:; Hoshi, N.; Kobayashi, T. Jpn. Kokai Tokkyo Koho JP06,228,164[94,228,164] (CL.C07F7/12).
39. 2O complex is mixed in a Schlenk flask with isopropanol which is removed under vacuum. The cycle is repeated 10-15 times. As a result of this treatment, an off-yellow powder is obtained which was found to be suitable for our synthetic purposes.