Airway exposure to bacterial superantigen (SEB) induces lymphocyte-dependent airway inflammation associated with increased airway responsiveness - A model for non-allergic asthma

European Journal of Immunology

Volumn 29, Issue 3, 1999, Pages 1021-1031

  Herz, Udo ^a   Rückert, René ^a   Wollenhaupt, Kathrin ^b   Tschernig, Thomas ^b   Neuhaus Steinmetz, Ulrich ^a   Pabst, Reinhard ^b   Renz, Harald ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Airway inflammation; Bronchial asthma; Intrinsic asthma; Superantigen

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 4; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CONTROLLED STUDY; DOSE RESPONSE; EOSINOPHIL; IMMUNE RESPONSE; INFLAMMATION; LUNG LAVAGE; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT MUCOSA; T LYMPHOCYTE;

EID: 0345222473     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4141(199903)29:03<1021::aid-immu1021>3.0.co;2-3     Document Type: Article

References (39)

1. Bousquet, J., Chanez, P., Lacoste, J. Y., Barnéon, G., Ghavanian, N., Enander, I., Venge, P., Ahlstedt, S., Simony-Lafontaine, J., Godard, P. and Michel, F.-B., ., Eosinophilic inflammation in asthma. N. Engl. J. Med. 1990. 323: 1033-1039.
2. Robinson, D. S., Hamid, Q., Ying, S., Tsicopolus, A., Bentley, A. M., Corrigan, C., Durham, S. R. and Kay, A. B., Predominant TH2-like bronchoalveolar., T-lymphocyte population in atopic asthma. N. Engl. J. Med. 1992. 326: 298-303.
3. Oshiba, A., Hamelmann, E., Takeda, K., Bradley, K. L., Loader, J. E., Larsen, G. L. and Gelfand, E. W., Passive transfer of immediate hypersensitivity and airway responsiveness by allergen-specific immunoglobulin (Ig) E and lgG1 in mice. J. Clin. Invest. 1996. 97: 1398-1408.
4. Hamelmann, E., Vella, A. T., Oshiba, A., Kappler, J. W., Marrack, P. and Gelfand, E. W., Allergic airway sensitization induces T-cell activation but not airway hyperresponsiveness in B cell-deficient mice. Proc. Natl. Acad. Sci. USA 1997. 94: 1350-1355.
5. Gavett, S. H., Chen, X., Finkelman, F. and Wills-Karp, M., Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am. J. Respir. Cell mol. Biol. 1994. 10: 587-593.
6. Van Oosterhout, A. J. M., Fattah, D., van Ark, I., Hotman, G., Buckley, T. L. and Nijkamp, F. P., Eosinophil infiltration precedes development of airway hyperreactivity and mucosal exudation after intranasal administration of interleukin-5 to mice. J. Allergy Clin. Immunol. 1995. 96: 104-112.
7. Brusselle, G., Kips, J., Joos, G., Bluethmann, H. and Pauwels, R., Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am. J. Respir. Cell Mol. Biol. 1995. 12: 254-259.
8. Foster, P. S., Hogan, S. P., Ramsay, A. J., Matthael; K. I. and Young, I. G., Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 1996. 183: 196-201.
9. Corry, D. B., Folkesson, H. G., Warnock, M. L., Erle, D. J., Matthay, M. A., Wiener-Kronish, J. P. and Locksley, R. M., Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 1996. 183: 109-117.
10. Renz, H., Bradley, K., Saloga, J., Loader, J., Larsen, G. L. and Gelfand, E. W., T-cells expressing specific Vβ elements regulate immunoglobulin E production and airways responsiveness in vitro. J. Exp. Med. 1993. 177: 1175-1180.
11. Lack, G., Renz, H., Saloga, J., Bradley, K. L., Loader, J., Leung, D. Y. M., Larsen, G. and Gelfand, E. W., Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airways function in a murine model of allergen sensitization. J. Immunol. 1994. 152: 2546-2553.
12. Renz, H., Lack, G., Saloga, J., Schwinzer, R., Bradley, K., Loader, J., Kupfer, A., Larsen, G. L. and Gelfand, E. W., Inhibition of IgE production and normalization of airways responsiveness by sensitized CD8 T-cells in a mouse model of allergen-induced sensitization. J. Immunol. 1994. 152: 351-360.
13. Renz, H., Bradley, K., Enssle, K., Loader, J. E., Larsen, G. L. and Gelfand, E. W., Prevention of the development of immediate hypersensitivity and airway hyperresponsiveness following in vivo treatment with soluble IL-4 receptor. Int. Arch. Allergy Immunol. 1996. 109: 167-176.
14. Oshiba, A., Hamelmann, E., Bradley, K. L., Loader, J. E., Renz, H., Larsen, G. L. and Gelfand, E. W., Pretreatment with allergen prevents immediate hypersensitivity and airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 1996. 153: 102-109.
15. Huhti, E., Mokka, T., Nikoskelainen, J. and Halonen, P., Association of viral and mycoplasma infections with exacerbations of asthma. Ann. Allergy 1974. 33: 145-149.
16. Yano, T., Ichikawa, Y., Komatu, S., Arai, S. and Oizumi, K., Association of Mycoplasma pneumoniae antigen with initial onset of bronchial asthma. Am. J. Respir. Crit. Care Med. 1994. 149: 1348-1353.
17. Allegra, L., Blasi, F., Centanni, S., Cosenzini, R., Denti, F., Raccanelli, R., Tarsia, P. and Valenti, V., Acute exacerbations of asthma in adults: role of Chlamydia pneumonia infection. Eur. Respir. J. 1994. 7: 2165-2169.
18. Virchow, J.-C., Walker, C., Hafner, D., Korstik, C., Werner, P., Matthys, H. and Kroegel, C., T-cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am. J. Respir. Crit. Care Med. 1995. 151: 960-968.
19. Mattoli, S., Mattoso, V. L., Soloperto, M., Allegra, L. and Fasoli, A., Cellular and biochemistral characteristic of bronchoalveolar lavage fluid in symptomatic non-allergic asthma. J. Allergy Clin. Immunol. 1991. 87: 794-802.
20. Bentley, A. M., Menz, G., Store, C., Robinson, D. S., Bradley, B., Jeffery, P. K., Durham, S. R. and Kay, A. B., Identification of T lymphocytes, macrophages and activated eosinophils in bronchial mucosa in intrinsic asthma. Am. Rev. Respir. Dis. 1992. 146: 500-506.
21. Schwarze, J., Hamelmann, E., Bradley, K. L., Takeda, K. and Gelfand, E. W., Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. J. Clin. Invest. 1997. 100: 226-233.
22. McKay, D. M. and Singh, P. K., Superantigen activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via IFN-γ and TNF-α. Inhibition of increased permeability, but not diminished secretory responses by TGF-β2. J. Immunol. 1997. 159: 2382-2390.
23. Hamad, A. R., Marrack, P. and Kappler, J. W., Transcytosis of staphylococcal superantigen toxins. J. Exp. Med. 1997. 185: 1447-1454.
24. White, J., Herman, A., Pullen, A. M., Kubo, R., Kappler, J. W. and Marrack, P., The Vβ-specific superantigen Staphylococcal enterotoxin B. Stimulation of mature T-cells and clonal deletion in neonatal mice. Cell 1989. 56: 27-35.
25. Rellahan, B. L., Jones, L. A., Kruisbeek, A. M., Fry, A. M. and Matis, L. A., In vivo induction of anergy in peripheral Vβ8+ T-cells by Staphylococcal enterotoxin B. J. Exp. Med. 1990. 172: 1091-1100.
26. Miethke, T., Wahl, C., Heeg, K., Echtenacher, B., Krammer, P. H. and Wagner, H., T-cell-mediated lethal shock triggered in mice by the superantigen Staphylococcal enterotoxin B: critical role of tumor necrosis factor. J. Exp. Med. 1992. 175: 91-98.
27. Herrman, T., Baschieri, S., Lees, R. K. and McDonald, H. R., In vivo responses of CD4+ and CD8+ cells to bacterial superantigens. Eur. J. Immunol. 1992. 22: 1935-1938.
28. Irwin, M. J., Hudson, K. R., Ames, K. T., Fraser, J. D. and Gascoigne, N. R. J., T-cell receptor β-chain binding to enterotoxin superantigens. Immunol. Rev. 1993. 131: 61-78.
29. Kips, J. C., Tavernier, J. and Pauwels, R. A., Tumor necrosis factor causes bronchial hyperresponsiveness in rats. Am. Rev. Respir. Dis. 1992. 145: 332-336.
30. Zuany-Amorim, C., Hallé, S., Leduc, D., Dumarey, C., Huerre, M., Vargaftig, B. B. and Pretolani, M., Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J. Clin. Invest. 1995. 95: 2644-2651.
31. Lukacs, N. W., Stricter, R. M., Chenusue, S. W., Widmer, M. and Kunkel, S. L., TNF-α mediates recruitment of neutrophils and eosinophils during airway inflammation. J. Immunol. 1995. 154: 5411-5417.
32. Kawabe, Y. and Ochi, A., Programmed cell death and extrathymic reduction of Vβ8+CD4+ T-cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 1991. 349: 245-248.
33. MacDonald, H. R., Baschieri, S. and Lees, R. K., Clonal expansion precedes anergy and death of Vβ8+ peripheral T-cells responding to staphylococcal enterotoxin B in vivo. Eur. J. Immunol. 1991. 21: 1963-1966.
34. Gonzalo, J. A., Moreno de Alborán, L., Alés-Martinez, J. E., Martinez-A., C. and Kroemer, G., Expansion and clonal deletion of peripheral T-cells induced by bacterial superantigen is independent of the interleukin-2 pathway. Eur. J. Immunol 1992. 22: 1007-1011.
35. Walker, C., Bode, E., Boer, L., Hansel, T. T., Blaser, K. and Virchow, J. C., Allergic and non-allergic asthmatics have distinct pattern of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 1992. 146: 109-115.
36. Humpert, M., Durham, S. R., Ying, S., Kimmitt, P., Barkans, J., Assoufi, B., Pfister, R., Menz, G., Robinson, D. S., Kay, A. B. and Corrigan, C. J., IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and non-atopic asthma: Evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am. J. Respir. Crit. Care Med. 1996. 154: 1497-1504.
37. Ying, S., Humbert, M., Barkans, J., Corrigan, C. J., Pfister, R., Menz, G., Larche, M., Robinson, D. S., Durham, S. R. and Kay, A. B., Expression of IL-4 and IL-5 mRNA and protein product by CD4 and CD8 T-cells, eosinophils and mast cells in bronchial biopsies obtained from atopic and non-atopic (intrinsic) asthmatics. J. Immunol. 1997. 158: 3539-3544.
38. Herz, U., Braun, A., Rückert, R. and Renz, H., Various immunological phenotypes are associated with increased airway responsiveness. Clin. Exp. Allergy 1998. 28: 625-634.
39. Vijayaraghavan, R., Schaper, M., Thompson, R., Stock, M. F. and Alarie, Y., Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract. Arch. Toxicol. 1993. 67: 478-490.