Structure and antibiotic activity of fragment peptides of antifungal protein isolated from Aspergillus giganteus

Journal of Microbiology and Biotechnology

Volumn 9, Issue 3, 1999, Pages 276-281

  Shin, Song Yub ^a   Kang, Joo Hyun ^a   Lee, Dong Gun ^a   Jin, Zhe Zhu ^b   Jang, So Youn ^a   Kim, Kil Lyong ^a   Hahm, Kyung Soo ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b YANBIAN UNIVERSITY   (China)

Author keywords

Anfifungal protein; Aspergillus giganteus; Fragment peptides; Functional sequence

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; FUNGAL PROTEIN;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPERGILLUS; BIOTECHNOLOGY; CIRCULAR DICHROISM; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; NONHUMAN; PEPTIDE ANALYSIS;

ASPERGILLUS GIGANTEUS;

EID: 0345211556     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Bessalle, R., A. Gorea, I. Shalit, J. W. Metzger, C. Dass, D. M. Desiderio, and M. Fridkin. 1993. Structure-function studies of amphipathic antibacterial peptides. J. Med. Chem. 36: 1203-1209.
2. Bruix, M., M. A. Jimenez, J. Santoro, C. Gonzalez, F. J. Colilla, E. Mendez, and M. Rico. 1993. Solution structure of gamma 1-H and gamma 1-P thionins from barley and wheat endosperm determined by 1-H NMR: A structural motif common to toxic arthropod proteins. Biochemistry 32: 715-724.
3. Campos-Olivas, R., M. Bruix, J. Santoro, J. Lacadena, del Pozo. A. Martinez, J. G. Gavilanes, and M. Rico. 1995. NMR solution structure of the antifungal protein from Aspergillus giganteus: Evidence for cysteine pairing isomerism. Biochemistry 34: 3009-3021.
4. Chen, Y.-H., J. T. Yang, and K. H. Chau. 1974. Determination of the helix and β form of proteins in aqueous solution by circular dichroism. Biochemistry 13: 3350-3359.
5. Javadpour, M. M., M. M. Juban, W.-C. J. Lo, S. M. Bishop, J. B. Alberty, S. M. Cowell, C. L. Becker, and M. L. McLaughlin. 1996. De novo antimicrobial peptides with low mammalian cell toxicity. J. Med. Chem. 39: 3107-3113.
6. Kang, J. H., S. Y. Shin, M. K. Lee, and K.-S. Hahm. 1998. Release of aqueous contents from phospholipid vesicles induced by cecropin A(1-8)-magainin 2(1-12) hybrid and its analogues. J. Peptide Res. 50: 279-285.
7. Lacadena, J., A. Martinez del Pozo, M. Gasset, B. Patino, R. Campos-Olivas, C. Vazquez, A. Martinez-Ruiz, J. M. Mancheno, M. Onaderra, and J. G. Gavilanes. 1995. Characterization of the antifungal protein secreted by the mould Aspergillus giganteus. Arch. Biochem. Biophys. 324: 273-281.
8. Lee, D. G., Z. Z. Jin, S. Y. Shin, J. H. Kang, K.-S. Hahm, and K. L. Kim. 1998. Structure-antifungal activity relationships of cecropin A-magainin2 and cecropin A-melittin hybrid peptides on pathogenic fungal cells. J. Microbiol. Biotechnol. 8: 595-600.
9. McLean, L. R., K. A. Hagaman, T. J. Owen, and J. L. Krstenansky. 1991. Minimal peptide length for interaction of amphipathic α-helical peptides with phosphatidylcholine liposomes. Biochemistry 30: 31-37.
10. Merrifield, R. B. 1986. Solid phase synthesis. Science 232: 341-347.
11. Nakaya, K., K. Omata, I. Okahashi, Y. Nakamura, H. Kolkenbrock, and N. Ulbrich. Amino acid sequence and disulfide bridges of an antifungal protein isolated from Aspergillus giganteus. Eur. J. Biochem. 19: 31-38.
12. Nir, S., J. Bentz, and J. Wilschut. 1980. Mass action kinetics of phosphatidylserine vesicle fusion as monitored by coalescence of initial vesicle volumns. Biochemistry 19: 6030-6036.
13. Ohki, S., E. Marcus, D. K. Sukumaram, and K. Arnold. 1994. Interaction of melittin with lipid membranes. Biochim. Biophys. Acta 1194: 223-232.
14. Shin, S. Y., J. H. Kang, M. K. Lee, K. L. Kim, S. Y. Kim, Y. Kim, and K.-S. Hahm. 1998. Cecropin A-magainin 2 hybrid peptides having potent antimicrobial activity with low hemolytic effect. Biochem. Mol. Biol. Int. 44: 1119-1126.
15. Shin, S. Y., M. K. Lee, K. L. Kim, and K.-S. Hahm. 1997. Structure-antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A-magainin 2 and cecropin A-melittin hybrid peptides. J. Peptide Res. 50: 279-285.
16. Thevissen, K., A. Ghazi, W. De. Samblanx, G. C. Brownlee, R. W. Osborn, and W. F. Broekaert. 1996. Fungal membrane response induced by plant defensins and thionins. J. Biol. Chem. 271: 15018-15025.
17. Utsugi, T., A. J. Schroit, J. Connor, C. D. Bucana, and I. J. Fidler. 1991. Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes. Cancer Res. 51: 3062-3066.
18. Van Blitterwijk, W. J., G. De Veer, J. H. Krol, and P. Emmelot. 1982. Comparative lipid analysis of purified plasma membranes and shed extraxellular membrane vesicles from normal murine thymocytes and leukemic GRSL cells. Biochim. Biophys. Acta 688: 495-504.
19. Wnendt, S., N. Ulbrich, and U. Stahl. 1990. Cloning and nucleotide sequence of a cDNA encoding the antifungal-protein of Aspergillus giganteus and preliminary characterization of the native gene. Nucl. Acids Res. 18: 3987.
20. Wnendt, S., N. Ulbrich, and U. Stahl, 1994. Molecular cloning, sequence analysis and expression of the gene encoding on antifungal-protein from Aspergillus giganteus. Curr. Genet. 25: 519-523.
21. Wool, I. G., A. Gluck, and Y. Endo. 1992. Ribotoxin recognition of ribosomal RNA and a proposal for the mechanism of translocation. Trends Biochem. Sci. 17: 266-269.