Biocompatibility and Other Properties of Acrylic Bone Cements Prepared with Antiseptic Activators

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 66, Issue 2, 2003, Pages 502-513

  De La Torre, B ^a   Fernandez M ^a   Vazquez B ^a   Collia F ^b   De Pedro, J A ^b   Lopez Bravo A ^c   San Roman J ^a  

^a INSTITUTO DE CIENCIA Y TECNOLOGÍA DE POLÍMEROS   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c HOSPITAL PROVINCIAL DE ÁVILA   (Spain)

Author keywords

Acrylic bone cements; Biocompatibility; N,N dimethylaminobenzyl alcohol and 4,4 dimethylamino benzydrol; Poly(methyl methacrylate)

Indexed keywords

ACRYLICS; BONE CEMENT; COLLAGEN; CURING; MICROORGANISMS; MUSCLE; TOXICITY;

ANTISEPTIC ACTIONS;

BIOCOMPATIBILITY;

4,4' DIMETHYLAMINOBENZYDROL; ACRYLIC CEMENT; ANTIINFECTIVE AGENT; N,N DIMETHYLAMINOBENZYL ALCOHOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; BIOCOMPATIBILITY; CONNECTIVE TISSUE; CONTROLLED STUDY; CYTOTOXICITY; HISTOLOGY; IMPLANTATION; LD 50; MATERIAL STATE; MECHANICS; NEUTROPHIL; NONHUMAN; OSSIFICATION; POSTOPERATIVE INFECTION; RABBIT; SYNTHESIS; TEMPERATURE DEPENDENCE; TOXICITY;

EID: 0345169034     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.b.10013     Document Type: Article

References (28)

1. Brauer GM, Steinberger DR, Stansbury JW. Dependence of curing time, peak temperature and mechanical properties on composition of bone cement. J Biomed Mater Res 1986;20: 839-852.
2. Trap B, Wolf P, Jensen JS. Acrylic bone cements: Residuals and extractability of methacrylate monomers and aromatic amines. J Appl Biomater 1992;3:51-57.
3. Brauer GM, Termini DJ, Dickson G. Analysis of the ingredients and determination of the residual components of acrylic bone cements. J Biomed Mater Res 1977;11:577-607.
4. Boesch P, Harms H, Lintner F. Detection of catalytic constituents of dimethyl-p-toluidine even after long term implantation. Arch Toxicol 1982;51:157-166.
5. Ege W, Scheuermann H. Release of rest monomers and N,N-dimethyl-p-toluidine from bone cements during aging and long-term placement: an in vitro study. Aktuel Prob Chir Orthop 1987;31:79-82.
6. Liso PA, Vázquez B, Rebuelta M, Hernáez ML, Rotger R, San Román J. Analysis of the leaching and toxicity of new amine activators for the curing of acrylic bone cements and composites. Biomaterials 1997;18:15-20.
7. Stea S, Granchi D, Zolezzi C, Ciapetti G, Visentin M, Cavedagna D, Pizzoferrato A. High-performance liquid chromatography assay of N,N-dimethyl-p-toluidine released from bone cements: Evidence for toxicity. Biomaterials 1997;18:243-246.
8. Taningher M, Pasquín R, Bonatti S. Genotoxicity analysis of N,N-dimethylaniline and N,N-dimethyl-p-toluidine. Environ Mol Mutagen 1993;21:349-356.
9. Vázquez B, Elvira C, Levenfeld B, Pascual B, Goñi I, Gurruchaga M, Ginebra MP, Gil FX, Planell JA, Liso PA, Rebuelta M, San Román J. Application of tertiary amines with reduced toxicity to the curing process of acrylic bone cements. J Biomed Mater Res 1997;34:129-136.
10. Elvira C, Levenfeld B, Vázquez B, San Román J. Amine activators for the cool peroxide initiated polymerisation of acrylic monomers. J Polym Sci Part A: Polym Chem 1996;34: 2783-2789.
11. ASTM Specification F451-86. Standard specification for acrylic bone cement. 1986 Annual Book of ASTM Standards. Medical Devices. Philadelphia: American Society for Testing and Materials; 1986.
12. Pascual B, Vázquez B, Gurruchaga M, Goñi I, Ginebra MP, Gil FJ, Planell JA, Levenfeld B, San Román J. New aspects of the effect of size and size distribution on the setting parameters and mechanical properties of acrylic bone cements. Biomaterials 1996;17:509-516.
13. ISO International Standard ISO 527-1. Plastics-Determination of tensile properties; 1993.
14. Lewis G. Properties of acrylic bone cement: State of the art review. J Biomed Mater Res 1997;38:155-182.
15. Jensen LN, Sturup J, Kramhoft M, Jensen JS. Histological evaluation of cortical bone reaction to PMMA cement. Acta Orthop Belg 1991;57:254-259.
16. Sturup J, Madsen J, Tondevold E, Jensen JS. Decreased blood perfusion in canine tibial diaphysis after filling with acrylic bone cement compared with inert bone wax. Acta Orthop Scand 1990;61:143-147.
17. Liu YK, Park JB, Njus GO, Stienstra D. Bone-particle-impregnated bone cement: an in vitro study. J Biomed Mater Res 1987;21:247-261.
18. Mazzullo S, Paolini M, Verdi C. Numerical simulation of thermal bone necrosis during cementation of femoral prostheses. J Math Biol 1991;29:475-494.
19. Kindt-Larsen T, Smith DB, Jensen JS. Innovations in acrylic bone cement and application equipment. J Appl Biomater 1995; 6:75-83.
20. Revell PA, Braden M, Freeman MAR. Review of the biological response to a novel bone cement containing poly(ethyl methacrylate) and n-butyl methacrylate. Biomaterials 1998;19:1579-1586.
21. Meachim G, Brooke G, Pedley RB. The tissue response to acrylic particles implanted in animal muscle. Biomaterials 1982:3:213-219.
22. Revell P, Braden M, Weightman B, Freeman M. Experimental studies of the biological response to a new bone cement: II Soft reactions in the rat. Clin Mater 1992;10:233-238.
23. Van Mullen PJ, Vaandrager JM, Nicolai JP, De Wijn JR. Implantation of porous acrylic cement in soft tissues: An animal and human biopsy histological study. Biomaterials 1990;11: 299-304.
24. Cohen J. Assay of foreign body reaction. J Bone Joint Surg 1959;41(A):152-156.
25. Willert HG, Buchhorn GH. Osseointegration of cemented and non-cemented implants in artificial hip replacement: Long-term findings in man. J Long-Term Effects Med Implants 1999;9: 113-130.
26. Charnley J. The reaction of bone to self-curing acrylic cement. A long-term histological study in man. J Bone Joint Surg 1970;52(B):340-353.
27. Freeman MA, Bradley GW, Rewell PA. Observations upon the interface between bone and polymethylmethacrylate cement. J Bone Joint Surg 1982;64(B):489-493.
28. Chambers TJ. The cellular basis of bone resorption. Clin Orthop 1980;151:283-293.