A method for determining whether hypotension caused by novel compounds in preclinical development results from histamine release

Journal of Pharmacological and Toxicological Methods

Volumn 49, Issue 1, 2004, Pages 31-37

  Blom, Jason D ^a   Yang, Po Chang ^a   Nicholson, Nancy S ^a   Case, Brenda L ^b   Parlow, John J ^b   South, Michael S ^b   Wegner, Craig D ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b Dept Med and Combinatorial Chem ^*  (United States)

Author keywords

Compound 48 80; Cromolyn; Histamine; Hypotension; Methods; Rat; SC 372

Indexed keywords

ACETAMIDE DERIVATIVE; COMPOUND 48-80; CROMOGLYCATE DISODIUM; HISTAMINE; N [4 [AMINO(IMINO)METHYL]BENZYL] 2 [6 (3 AMINOPHENYL) 5 CHLORO 3 (CYCLOBUTYLAMINO) 2 OXOPYRAZIN 1(2H) YL]ACETAMIDE; THIOBUTABARBITAL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; BLOOD PRESSURE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; HISTAMINE BLOOD LEVEL; HISTAMINE RELEASE; HYPOTENSION; MALE; MAST CELL; NONHUMAN; RAT;

EID: 0345167241     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2003.08.002     Document Type: Article

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