Responses to ischaemia and reperfusion in the mouse isolated perfused heart and the phenomenon of 'contractile cycling'

Clinical and Experimental Pharmacology and Physiology

Volumn 30, Issue 11, 2003, Pages 879-884

  Sutherland, Fiona J ^a   Baker, Kathryn E ^a,b   Shattock, Michael J ^a   Hearse, David J ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b SIMBEC RESEARCH LTD   (United Kingdom)

Author keywords

Contractile cycling; Ischaemia reperfusion; Langendorff perfusion; Murine; Strain variation

Indexed keywords

ACETIC ACID; BUFFER; CREATINE KINASE; GLUCOSE; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; HEART CONTRACTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE REPERFUSION; HEART PERFUSION; ISCHEMIA; ISOLATED HEART; MALE; METABOLIC DISORDER; MOUSE; MOUSE STRAIN; NONHUMAN; SYSTOLIC BLOOD PRESSURE;

ANIMALS; HEART; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; SPECIES SPECIFICITY; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0345167072     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2003.03926.x     Document Type: Conference Paper

References (6)

1. Sutherland FJ, Shattock MJ, Baker KE, Hearse DJ. Mouse isolated perfused heart: Characteristics and cautions. Clin. Exp. Pharmacol. Physiol. 2003; 30: 867-78.
2. Hearse DJ, Sutherland FJ. Catecholamines and preconditioning. Studies of contraction and function in isolated rat hearts. Am. J. Physiol. 1999; 277: H136-43.
3. Hearse DJ, Sutherland FJ. Cardioprotection: Intermittent ventricular fibrillation and rapid pacing can induce preconditioning in the blood-perfused rat heart. J. Mol. Cell. Cardiol. 1999; 31: 1961-73.
4. Bao W, Guo Y, Tang XL, Wu WJ, Bolli R. Variability in susceptibility to ischemia among different strains of mice. J. Mol. Cell. Cardiol. 2000; 32: A21 (Abstract).
5. Sutherland FJ, Baker KE, Hearse DJ. Unpredictable cycle pressure fluctuations: A complication in isolated murine heart perfusion. J. Mol. Cell. Cardiol. 2000; 32: A37 (Abstract).
6. Wang Q-D, Tokuno S, Valen G, Sjöquist P-O, Thorén P. Cyclic fluctuations in the cardiac performance of the isolated Langendorff-perfused mouse heart: Pyruvate abolishes the fluctuations and has an anti-ischaemic effect. Acta Physiol. Scand. 2002; 175: 279-87.