Antibody responses to Porphyromonas gingivalis infection in a murine abscess model - Involvement of gingipains and responses to re-infection

Journal of Periodontal Research

Volumn 38, Issue 6, 2003, Pages 551-556

  Yoneda, Masahiro ^a   Hirofuji, Takao ^b   Motooka, Noriko ^a   Anan, Hisashi ^a   Hamachi, Takafumi ^a   Miura, Mayumi ^a   Ishihara, Yoshihisa ^a   Maeda, Katsumasa ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b FUKUOKA DENTAL COLLEGE   (Japan)

Author keywords

Gingipains; Murine abscess model; Porphyromonas gingivalis; Re infection

Indexed keywords

GINGIPAIN R; IMMUNOGLOBULIN G;

ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIUM CULTURE; CONTROLLED STUDY; FEMALE; IMMUNITY; INFECTION RESISTANCE; MOUSE; NONHUMAN; PORPHYROMONAS GINGIVALIS; REINFECTION; SERUM; WESTERN BLOTTING; WILD TYPE;

ABSCESS; ADHESINS, BACTERIAL; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTEROIDACEAE INFECTIONS; CYSTEINE ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; FEMALE; HEMAGGLUTININS; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; MUTATION; PORPHYROMONAS GINGIVALIS; VIRULENCE;

EID: 0345166884     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0765.2003.00685.x     Document Type: Article

References (27)

1. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994; 5:78-111.
2. Naito Y, Okuda K, Takazoe I, Watanabe H, Ishikawa I. The relationship between serum IgG levels to subgingival gram-negative bacteria and degree of periodontal destruction. J Dent Res 1985;64:1306-1310.
3. Yoshimura F. Molecular biology of P. gingivalis fimbriae. In: Shah, HN, Mayrand, D, Genco, RJ, eds. Biology of the species Porphyromonas gingivalis. Florida: CRC Press, 1993: 321-338.
4. Wilson M. Biological activities of lipopolysaccharide and endotoxin. In: Shah, HN, Mayrand, D, Genco, RJ, eds. Biology of the species Porphyromonas gingivalis. Florida: CRC Press, 1993: 171-197.
5. Grenier D, Mayrand D, Proteinases. In: Shah, HN, Mayrand, D, Genco, RJ, eds. Biology of the species Porphyromonas gingivalis. Florida: CRC Press, 1993: 227-243.
6. Yoneda M, Maeda K, Aono M. Suppression of bactericidal activity of human polymorphonuclear leukocytes by Bacteroides gingivalis. Infect Immun 1990; 58:406-411.
7. Kadowaki T, Yoneda M, Okamoto K, Maeda K, Yamamoto K. Purification and characterization of a novel arginine-specific cysteine proteinase (argingipain) involved in the pathogenesis of periodontal disease from the culture supernatant of Porphyromonas gingivalis. J Biol Chem 1994;269:21371-21378.
8. Chen Z, Potempa J, Polanowski A et al. Purification and characterization of 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis. J Biol Chem 1992;267:18896-18901.
9. Kuramitsu HK. Proteases of Porphyromonas gingivalis: what don't they do? Oral Microbiol Immunol 1998;13:263-270.
10. Nakayama K, Kadowaki T, Okamoto K, Yamamoto K. Construction and characterization of arginine-specific cysteine proteinase (arg-gingipain)- deficient mutants of Porphyromonas gingivalis. J Biol Chem 1995;270:23619-23626.
11. Yoneda M, Hirofuji T, Anan H et al. Mixed infection of Porphyromonas gingivalis and Bacteroides forsythus in a murine abscess model: involvement of gingipains in a synergistic effect. J Periodont Res 2001;36:237-243.
12. Shi Y, Ratnayake DB, Okamoto K, Abe N, Yamamoto K, Nakayama K. Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. J Biol Chem 1999; 274:17955-17960.
13. Kastelein P, van Steenbergen TJM, Bras TJM, DeGraaff J. An experimentally induced phlegmonous abscess by a strain of Bacteroides gingivalis in guinea pigs and mice. Antonie Van Leeuwenhoek 1981; 47:1-9.
14. Kesavalu L, Ebersole JL, Machen RL, Holt SC. Porphyromonas gingivalis virulence in mice: induction of immunity to bacterial components. Infect Immun 1992; 60:1455-1464.
15. O'Brien-Simpson NM, Black CL, Bhogal PS et al. Serum immunogloblin G (IgG) and IgG subclass responses to the RgpA-Kgp proteinase-adhesin complex of Porphyromonas gingivalis in adult periodontitis. Infect Immun 2000;68:2704-2712.
16. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1976;227: 680-685.
17. Fletcher HM, Schenkein HA, Morgan RM, Bailey KA, Berry CR, Macrina FL. Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene. Inject Immun 1995;63:1521-1528.
18. McKee AS, McDermid AS, Wait R, Baskerville A, Marsh PD. Isolation of colonial variants of Bacteroides gingivalis W50 with a reduced virulence. J Med Microbiol 1988;27:59-64.
19. Yoneda M, Kuramitsu HK. Genetic evidence for the relationship of Porphyromonas gingivalis cysteine protease and hemagglutinin activities. Oral Microbiol Immunol 1996;11:129-134.
20. Kuramitsu H, Tokuda M, Yoneda M, Duncan M, Cho M-I. Multiple colonization defects in a cysteine protease mutant of Porphyromonas gingivalis. J Periodont Res 1997;32:140-142.
21. Tokuda M, Duncan M, Cho M-I et al. Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces. Infect Immun 1996;64:4067-4073.
22. Tokuda M, Karunakaran T, Duncan M et al. Role of Arg-gingipain A in virulence of Porphyromonas gingivalis. Infect Immun 1998;66:1159-1166.
23. Kadowaki T, Nakayama K, Yoshimura F, Okamoto K, Abe N, Yamamoto K. Arg-gingipain acts as a major processing enzyme for various cell surface proteins in Porphyromonas gingivalis. J Biol Chem 1998;273:29072-29076.
24. Genco CA, Odusanya BM, Potempa J, Mikolajczyk-Pawlinska J, Travis J. A peptide domain on gingipain R which confers immunity against Porphyromonas gingiralis infection in mice. Infect Immun 1998;66:4108-4114.
25. O'Brien-Simpson NM, Paolini RA, Reynolds EC. RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model. Inject Immun 2000;68:4055-4063.
26. Kabashima H, Yoneda M, Hirofuji T, Nagata K, Maeda K. The presence of chemokine (MCP-1, MIP-1α, MIP-1β, IP-10, RANTES)-positive cells and chemokine receptor (CCR5, CXCR3)-positive cells in human gingival tissues. Cytokine 2000;20:70-77.
27. Kitamura Y, Yoneda M, Imamura T et al. Gingipains in the culture supernatant of Porphyromonas gingivalis cleave CD4 and CDS on human T cells. J Periodont Res 2002;37:464-468.