A new computerized biomechanical perfusion model for ex vivo study of fluid mechanical forces in intact conduit vessels

Journal of Vascular Research

Volumn 36, Issue 1, 1999, Pages 68-78

  Gan, Li Ming ^a   Sjögren, Lena Selin ^a   Doroudi, Roya ^a   Jern, Sverker ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Computer; Perfusion; Pressure; Prostaglandin E2; Shear stress

Indexed keywords

PROSTAGLANDIN E2;

ACCURACY; ARTICLE; BIOMEDICAL ENGINEERING; BLOOD VESSEL WALL; COMPUTER MODEL; HEMODYNAMICS; IN VITRO STUDY; MATHEMATICAL ANALYSIS; MECHANICAL STRESS; NONHUMAN; PERFUSION; PRESSURE; PRIORITY JOURNAL; SHEAR STRESS; VASCULAR ENDOTHELIUM;

EID: 0345130060     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000025627     Document Type: Article

References (24)

1. Bardy N, Karillon GJ, Merval R, Samuel J-L, Tedgui A: Differential effects of pressure and flow on DNA and protein synthesis and on fibronectin expression by arteries in a novel organ culture system. Circ Res 1995;77:684-694.
2. Wieczorek KM, Brewer AS, Myatt L: Shear stress may stimulate release and action of nitric oxide in the human fetal-placental vasculature. Am J Obstet Gynecol 1995;173:708-713.
3. 2 in ex vivo-perfused canine veins. J Vasc Surg 1988;7:99-106.
4. Davies PF, Tripathi SC: Mechanical stress mechanisms and the cell. Circ Res 1993;72: 239-245.
5. Diamond SL, Eskin SG, McIntire LV: Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cells. Science 1989;243:1483-1485.
6. Diamond SL, Sharefkin JB, Dieffenbach C, Frasier-Scott K, McIntire LV, Eskin SG: Tissue plasminogen activator messenger RNA levels increase in cultured human endothelial cells exposed to laminar shear stress. J Cell Physiol 1990;143:364-371.
7. Frangos JA, McIntire LV, Eskin SG: Shear stress induced stimulation of mammalian cell metabolism. Biotechnol Bioeng 1988;32:1053-1060.
8. Noris M, Morigi M, Donadelli R, Aiello S, Foppolo M, Todeshini M, Orisio S, Remuzzi G, Remuzzi A: Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ Res 1994;76:536-543.
9. Chamley-Campbell JH, Campbell GR, Ross R: Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens. J Cell Biol 1981;89:379-383.
10. Gabbiani G, Elemer G, Guelpa C, Valloton MB, Badonnel MC, Huttner I: Morphologic and functional changes of the aortic intima during experimental hypertension. Am J Pathol 1979;96:399-422.
11. Brunkwall JS, Stanley JC, Graham LM, Burkel WE, Bergqvist D: Comparison of static incubation versus physiologic perfusion techniques for quantitation of luminal release of prostacyclin and thromboxane in canine arteries and veins. J Surg Res 1988;45:1-7.
12. Haugen G, Stray-Pedersen S, Bjoro K: Prostanoid production in umbilical arteries from preterm and term deliveries in vitro. Early Hum Dev 1990;24:153-161.
13. Hornbeck RW: Laminar flow in the entrance region of a pipe. Appl Sci Res 1964;13:224-232.
14. 2 by vascular smooth muscle cells. Biochem Biophys Res Commun 1996;224:808-814.
15. Hornych A: The deficit of prostacyclin in the pathogenesis of hypertension. Cor Vasa 1991; 33:492-505.
16. Akar F, Ark M, Uydes BS, Soysal ME, Saracoglu F, Abacioglu N, Van de Voorde J, Kanzik I: Nitric oxide production by human umbilical vessels in severe pre-eclampsia. J Hypertens 1994;12:1235-1241.
17. Brunkwall JS, Stanley JC, Graham LM, Burkel WE, Bergqvist D: Prostanoid release from ex vivo perfused canine arteries and veins: Effects of prolonged perfusion, intermittent perfusion as well as exposure to exogenous arachidonic acid, thrombin and bradykinin. Thromb Haemost 1989;62:1034-1039.
18. Hishikawa K, Nakaki T, Marumo T, Suzuki H, Kato R, Saruta T: Pressure enhances endothelin-1 release from cultured human endothelial cells. Hypertension 1994;25:449-452.
19. Gorfien SF, Winston FK, Thibault LE, Macarak EJ: Effects of biaxial deformation on pulmonary artery endothelial cells. J Cell Physiol 1989;139:492-500.
20. 2 in cultured human amnion cells. Gynecol Obstet Invest 1989;28:123-126.
21. Leung DYM, Glagov S, Mathews MB: Cyclic stretching stimulates synthesis of matrix components by arterial smooth muscle cells in vitro. Science 1976;191:475-477.
22. Predel HG, Von Segesser ZYL, Turina M, Bühler FR, Luscher TF: Implications of pulsatile stretch on growth of saphenous vein and mammary artery smooth muscle. Lancet 1992; 340:878-879.
23. Bussolari SR, Osterle JF, Gimbrone MA: Apparatus for subjecting living cells to fluid shear stress. Rev Sci Instrum 1982;53:1851-1854.
24. Fewell ME, Hellums JD: The secondary flow of Newtonian fluids in cone-and-plate viscometers. Trans Soc Rheol 1977;21:535-565.