Changes of precore nucleic acid sequence in chronic hepatitis B patients with and without interferon administration

Hepatology Research

Volumn 15, Issue 2, 1999, Pages 136-144

  Won Cho, Sung ^a   Jun Shin, Young ^a   Soo Kim, Young ^a   Hyeon Jin, Joo ^a   Baik Hahm, Ki ^a   Hong Kim, Jin ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Hepatitis B; Interferon; Mutation; Precore region

Indexed keywords

ALPHA INTERFERON; HEPATITIS B ANTIBODY; NUCLEIC ACID; VIRUS DNA;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; IMMUNOTHERAPY; MALE; MUTATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0345120856     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(99)00024-8     Document Type: Article

References (24)

1. Carman W.F., Jacyna M.R., Hadziyannis S. et al. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet. 1:1988;588-590.
2. Brunetto M.R., Giarin E., Oliver F. et al. Wild-type and e antigen-deficient hepatitis B viruses and course of chronic hepatitis. Proc. Natl. Acad. Sci. USA. 88:1991;4186-4190.
3. Carman W., Thomas H., Domingo E. Viral genetic variation: hepatitis B virus as a clinical sample. Lancet. 341:1993;349-353.
4. Lau J.Y.A., Wright T.L. Molecular virology and pathogenesis of hepatitis B. Lancet. 342:1993;1335-1340.
5. Lok A.S.F., Akarca U., Greene S. Mutations in the precore region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc. Natl. Acad. Sci. USA. 91:1994;4077-4081.
6. Li J., Tong S., Vitvitski L., Zoulim F., Trépo C. Rapid detection and further characterization of infection with hepatitis B virus variations containing a stop codon in the distal precore region. J. Virol. 71:1990;1993-1998.
7. Raimondo G., Schneider R., Stemler M. et al. A new hepatitis B virus variant in a chronic carrier with multiple episodes of viral reactivation and acute hepatitis. Virology. 179:1990;64-68.
8. Hadziyannis S.J., Lieberman H.M., Karvountzis G.G., Shafritz D.A. Analysis of liver disease, nuclear HBcAg, viral replication and hepatitis B virus DNA in liver and serum of HBeAg versus anti-HBe positive carriers of hepatitis B virus. Hepatology. 3:1983;656-662.
9. Lai M.E., Solinas A., Mazzoleni A.P. et al. The role of hepatitis B virus mutants on the long term outcome of chronic hepatitis B virus hepatitis: a longitudinal study. J. Hepatol. 20:1994;773-781.
10. Tur-Kaspa R., Klein A., Aharonson S. Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity. Hepatology. 16:1992;1338-1342.
11. Akarca U.S., Greene S., Lok A.S.F. Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members. Hepatology. 19:1994;1366-1370.
12. Raimondo G., Meucci G., Sardo M.A. et al. Persistence of wild-type and e-minus hepatitis virus infection in chronic healthy HBsAg/anti-HBe positive carriers. J. Hepatol. 20:1994;148-151.
13. Lampertico P., Manzin A., Rumi M.G. et al. Hepatitis B virus precore mutants in HBeAg carriers with chronic hepatitis treated with interferon. J. Viral. Hep. 2:1995;251-256.
14. Stiehm ER, Kronenberg LH, Rosenblatt MM, Bryson Y, Merigan TC, UCLA conference. Interferon: immunobiology and clinical significance. Ann of Intern Med 1982;96:80-93.
15. Takeda K., Akahane Y., Suzuki H. et al. Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy. Hepatology. 12:1990;1284-1289.
16. Gunther S., Meisel H., Reip A. et al. Frequent and rapid emergence of mutated precore sequences in HBV from e-antigen positive carriers who seroconvert to anti-HBe during interferon treatment. Virology. 187:1991;271-279.
17. Laskus T., Rakela J., Persing D.H. Nucleotide sequence analysis of precore and proximal core regions in patients with chronic hepatitis B treated with interferon. Dig. Dis. Sci. 40:1995;1-7.
18. Kwok S, Higuchi R. Avoiding false positives with PCR. Nature 1989;339: 237-238 (Erratum, Nature 1989;339:490).
19. Kwok S, Higuchi R. Avoiding false positives with PCR. Nature 1989;339: 237-238 (Erratum, Nature 1989;339:490).
20. Okamoto H., Yotsumoto S., Akahane Y. et al. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J. Virol. 64:1990;1298-1303.
21. Chang C., Enders G., Sprengel R., Peters N., Varmus H.E., Ganem D. Expression of the precore region of an avian hepatitis B virus is not required for viral replication. J. Virol. 61:1987;3322-3325.
22. Li J., Tong S., Wen Y.M., Vitvitsky L., Zhang Q., Trépo C. Hepatitis B virus genotype D rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region. J. Virol. 67:1993;5402-5410.
23. Brunetto M.R., Oliveri F., Rocca G. et al. Natural course and response to interferon of chronic hepatitis B accompanied by antibody to hepatitis B e antigen. Hepatology. 10:1989;198-202.
24. Chung W.L., Omata M., Ehata T. et al. Co-infection study of precore mutant and wild-type hepatitis B-like virus in ducklings. Hepatology. 19:1994;569-576.