Himalomycin A and B: Isolation and structure elucidation of new fridamycin type antibiotics from a marine Streptomyces isolate

Journal of Antibiotics

Volumn 56, Issue 11, 2003, Pages 942-949

  Maskey, Rajendra P ^a   Helmke, Elizabeth ^b   Laatsch, Hartmut ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b ALFRED WEGENER INSTITUTE FOR POLAR AND MARINE RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; ANTHRACYCLINE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; DEUTERIUM; FRIDAMYCIN D; HIMALOMYCIN A; HIMALOMYCIN B; N (PHENYLETHYL)ACETAMIDE; PROTON; RABELOMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; FERMENTATION; FUNGAL STRAIN; FUNGUS CULTURE; FUNGUS ISOLATION; ISOLATION AND PURIFICATION; METABOLITE; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STREPTOMYCES;

STREPTOMYCES;

EID: 0345116079     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.56.942     Document Type: Article

References (16)

1. Kricke, P.: Fridamycin, Anthracyclin-Analoge Antibiotica aus Tü 1989: Strukturaufklärung und Syntheseversuche. PhD thesis, University of Göttingen, 1984
2. Krohn, K. & W. Baltus: Synthesis of rac- and ent-fridamycin E. Tetrahedron 44: 49-54, 1988
3. Kawamura, N.; R. Sawa, Y. Takahashi, T. Sawa, N. Kinoshita, H. Naganawa, M. Hamada & T. Takeuchi: Amicenomycins A and B, new antibiotics from Streptomyces sp. MJ384-46F6. J. Antibiotics 48: 1521-1524, 1995
4. Omura, S.; H. Tanaka, R. Oiwa, J. Awaya, R. Masuma & K. Tanaka: New antitumor antibiotics, OS-4742 A1, A2, B1 and B2 produced by a strain of Streptomyces. J. Antibiotics 30: 908-916, 1977
5. Imamura, N.; K. Kakinuma, N. Ikekawa, H. Tanaka & S. Omura: The structure of vineomycin B2. J. Antibiotics 34: 1517-1518, 1981
6. Alvi, K. A.; D. D. Baker, V. Stienecker, M. Hosken & B. G. Nair: Identification of inhibitors of inducible nitric oxide synthase from microbial extracts. J. Antibiotics 53: 496-501, 2000
7. Imamura, N.; K. Kakinuma, N. Ikekawa, H. Tanaka & S. Omura: Biosynthesis of vineomycins A1 and B2. J. Antibiotics 35: 602-607, 1982
8. Shirling, E. B. & D. Gottlieb: Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16: 313-340, 1966
9. Helmke, E. & H. Weyland: Rhodococcus marinonascens sp. nov., an actinomycete from the sea. Int. J. Syst. Bacteriol. 34: 127-138, 1984
10. Biabani, M. A. F.; M. Baake, B. Lovisetto, H. Laatsch, E. Helmke & H. Weyland: Anthranilamides: new antimicroalgal active substance from a marine Streptomyces sp. J. Antibiotics 51: 333-340, 1998
11. Maskey, R. P.; R. N. Asolkar, E. Kapaun, I. Wagner-Döbler & H. Laatsch: Phytotoxic arylethylamides from limnic bacteria using a screening with microalgae. J. Antibiotics 55: 643-649, 2002
12. Liu, W-C.; W. L. Parker, D. S. Slusarchyk, G. L. Greenwood, S. F. Graham & E. Meyers: Isolation, characterization, and structure of rabelomycin, a new antibiotic. J. Antibiotics 23: 437-441, 1970
13. Matsuzawa, Y.; O. Toshikazu, T. Takeuchi & H. Umezawa: Structure-activity relationships of anthracyclines relative to cytotoxicity and effects on macromolecular synthesis in L1210 leukemia cells. J. Antibiotics 34: 1596-1607, 1981
14. Hoshino, T.; M. Tazoe, S. Nomura & A. Fujiwara: New anthracycline antibiotics, auramycins and sulfurmycins II. Isolation and characterization of 10 minor components (C-G). J. Antibiotics 35: 1271-1279, 1982
15. Uchida, T.; M. Imoto, Y. Watanabe, K. Miura, T. Dobashi, N. Matsuda, T. Sawa, H. Naganawa, M. Hamada, T. Takeuchi & H. Umezawa: Saquayamycins, new aquayamycin-group antibiotics. J. Antibiotics 38: 1171-1181, 1985
16. Sawada, Y.; T. Tsuno, T. Miyaki, T. Naito & T. Oki: New cirramycin-family antibiotics F-1 and F-2 selection of producer mutants, fermentation, isolation, structure elucidation and antibacterial activity. J. Antibiotics 42: 242-253, 1989