Chemotherapy of multidrug-resistant human lung cancer combined with an MDR1 ribozyme retroviral vector in an orthotopic model

Chinese Science Bulletin

Volumn 42, Issue 3, 1997, Pages 231-234

  Gao, Zhenqiang ^a   Gao, Zhiping ^a   Liu, Xifu ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Lung cancer; MDR1 ribozyme; Orthotopic model; Reversal of drug resistance; Therapy

Indexed keywords

EID: 0345100322     PISSN: 10016538     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02882442     Document Type: Article

References (7)

1. Gao, Z. Q., Gao, Z. P., Advances in multidrug resistance gene, Chin. J. Pathol. (in Chinese), 1996, (3): 185.
2. Gao, Z. Q., Gao, Z. P., Reversal of drug resistance in multidrug-resistant human lung cancer cells by retrovirus-mediated MDR1 antisense RNA, Chin. Sci. Bull., 1996, 41(21): 1852.
3. Gao, Z. Q., Zhang, Z. H., Gao, Z. P., Clinical correlates of MDR1 gene expression in human lung cancer, Chin. J. Internal. Med. (in Chinese), 1996, (7): 482.
4. Symons, R., Self-cleavage of RNA in the replicative of small pathogens of plants and animals, TIBS, 1989, 14: 445.
5. Gao, Z. Q., Gao, Z. P., Liu, X. F., Reversal of drug sensitivity in multidrug-resistant lung cancer cells by an MDR1 ribozyme retrovirus, Chin. Sci. Bull., 1996, 41(24): 2100.
6. Kohayashi, H., Dorai, T., Holland, J. et al., Reversal of drug sensitivity in multidrug-resistant tumor cells by an MDR1 (PGY1) ribozyme, Cancer Res., 1994, 53: 1271.
7. McLemore, T. L., Liu, M. C., Blacker, P.C. et al., Novel intrapulmonary model for orthotopic propagations in human lung cancers in athymic nude mice, Cancer Res., 1987, 47: 5132.