Immunohistochemical Proliferation Markers May Overestimate the Growth Potential after Ionizing Radiation: In Vivo Study in the Rat Anterior Pituitary Gland

Neurologia Medico-Chirurgica

Volumn 43, Issue 11, 2003, Pages 521-526

  Nakasu, Satoshi ^a   Nakasu, Yoko ^b   Fukami, Tadateru ^a   Matsuda, Masayuki ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b SHIZUOKA CANCER CENTER   (Japan)

Author keywords

Bromodeoxyuridine; Ki 67; Pituitary gland; Radiation; Topoisomerase II

Indexed keywords

BROXURIDINE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA TOPOISOMERASE (ATP HYDROLYSING); KI 67 ANTIGEN; PROTEIN; PROTEIN P27; TOPOISOMERASE II ALPHA; UNCLASSIFIED DRUG;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MARKER; HYPOPHYSIS; IMMUNOHISTOCHEMISTRY; IONIZING RADIATION; LABELING INDEX; NICK END LABELING; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; RADIATION DOSE; RAT;

ANIMALS; BROMODEOXYURIDINE; CELL DIVISION; DNA TOPOISOMERASES, TYPE II; KI-67 ANTIGEN; MODELS, ANIMAL; PITUITARY GLAND; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0345096364     PISSN: 04708105     EISSN: None     Source Type: Journal    
DOI: 10.2176/nmc.43.521     Document Type: Article

References (21)

1. Bigio EH, Colvin SM, Mickey BE, White CL III, Rushing EJ: Radiation change versus recurrent astrocytoma: diagnostic utility of the proliferation index? J Neurooncol 41: 55-63, 1999
2. kip1 for restriction point control of the fibroblast cell cycle. Science 272: 877-880, 1996
3. Colombel M, Olsson CA, Ng P-Y, Buttyan R: Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle. Cancer Res 52: 4313-4319, 1992
4. Deininger MH, Grote E, Wickboldt J, Meyermann R: Distinct radiochemotherapy protocols differentially influence cellular proliferation and expression of p53 and bcl-2 in glioblastoma multiforme relapses in vivo. J Neurooncol 48: 121-129, 2000
5. Dolbeare F: Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part 1: historical perspectives, histochemical methods and cell kinetics. Histochem J 27: 339-369, 1995
6. El-Deiry WJ, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B: WAF-1, a potential mediator of p53 tumor suppression. Cell 75: 817-823, 1993
7. Gerdes J: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MIB-3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 168: 357-363, 1992
8. Holden JA, Townsend JJ: DNA topoisomerase II-alpha as a proliferation marker in astrocytic neoplasms of the central nervous system: correlation with MIB-1 expression and patient survival. Mod Pathol 12: 1094-1100, 1999
9. Jennelle R, Gladson C, Palmer C, Guthrie B, Markert J: Paradoxical labelling of radiosurgically treated quiescent tumors with Ki-67, a marker of cellular proliferation. Stereotact Funct Neurosurg 72 (Suppl 1): 45-52, 1999
10. kip1 expression in non-tumorous and neoplastic human pituitaries. Am J Pathol 151: 509-519, 1997
11. Kalamitopoulou E, Peentes E, Diamantis I, Maraziotis T: Ki-67 immunoreactivity in human central nervous system tumors: A study with MIB-1 monoclonal antibody on archival material. Acta Neuropathol (Berl) 87: 47-54, 1994
12. Katchanov J, Harms C, Gertz K, Hauck L, Waeber C, Hirt L, Priller J, von Harsdorf R, Brück W, Hörtnagl H, Dirnagl U, Bhide PG, Endres M: Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal death. J Neurosci 21: 5045-5053, 2001
13. Nakasu S, Li D-H, Okabe H, Nakajima M, Matsuda M: Significance of MIB-1 staining indices in meningiomas. Comparison of two counting methods. Am J Surg Pathol 25: 472-478, 2001
14. Nakasu S, Nakajima M, Nakazawa T, Nakasu Y, Handa J: p53 accumulation and apoptosis in embolized meningiomas. Acta Neuropathol (Berl) 93: 599-605, 1997
15. Pierce E, Doshi R, Deane R: PCNA and Ki-67 labelling indices in pre-irradiated and post-irradiated astrocytomas: a comparative immunohistochemical analysis for evaluation of proliferative activity. Mol Pathol 51: 90-95, 1998
16. Poeze M, von Meyenfeldt MF, Peterse JL, George WD, De Jong JMA, Jager JJ, Thunnissen FBJ: Increased proliferative activity and p53 expression in normal glandular breast tissue after radiation therapy. J Pathol 185: 32-37, 1998
17. kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78: 59-66, 1994
18. kip1: Chromosomal mapping to 12p12-12p13.1 and absence of mutation in human tumors. Cancer Res 55: 1211-1214, 1995
19. Rudolph P, Tronnier M, Menzel R, Möller M, Parwaresch R: Enhanced expression of Ki-67, topoisomerase IIα, PCNA, p53 and p21WAF1/Cip1 reflecting proliferation and repair activity in UV-irradiated melanocytic nevi. Hum Pathol 29: 1480-1487, 1998
20. Toyoshima H, Hunter T: p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78: 67-74, 1994
21. Woessner RD, Mattern MR, Mirabelli CK, Johnson RK, Drake FH: Proliferation- and cell cycle-dependent differences in the expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells. Cell Growth Differ 2: 209-214, 1991